Pancreatic Metastasis of Renal Cell Carcinoma: Presentation, Treatment and Survival

Abstract

We advocate aggressive surgical resection when possible. Surgical removal of metastatic lesions prolongs survival but radical lymph node dissection is not mandatory. We also recommend careful long-term followup of patients with a history of renal cell carcinoma.

Clinical diagnosis and detection of genetic mutations of pancreatic metastases: A report of four cases and review of the literature

“…Out of all cases of pancreatic-occupying lesions, the reported incidence of pancreatic metastasis is 2-5% (1)(2)(3)(4)(5)7,14). In the present study, pancreatic metastases represented 1.02% of all cases of malignancies encountered in the pancreas.…”

“…Therefore, the proportion of patients affected by pancreatic metastases is speculated to be significantly higher based on the longer lifespans and improved sensitivity of diagnostic medical examinations. As pancreatic metastases almost always occur in elderly patients and those with later-stage malignancies, certain authors have suggested that the prognosis for pancreatic metastasis is better than primary pancreatic cancer (4,15). Research should be conducted to develop improved diagnostic and treatment techniques for pancreatic metastases.…”

“…Metastases are reported to account for 2-5% of all malignant lesions occurring in the pancreas (1)(2)(3)(4)(5). Studies have reported that people of ~60 years old are at high risk of developing pancreatic metastases (1)(2)(3).…”

“…Primary tumors that may give rise to pancreatic metastases include renal cell carcinoma (RCC), non-small cell lung carcinoma, melanoma, sarcoma and colorectal carcinoma. Previous studies have indicated that the kidney may be more common than the lung as a primary tumor site of metastases to the pancreas (1,4). Symptoms of pancreatic metastases are often not apparent, and these lesions are thus detected incidentally by physical examination in the majority of cases (6).…”

Targeted Therapy in the Management of Elderly Patients with Pancreatic Metastases from Renal Cell Carcinoma

“…Although these patients may suffer from particular complications (such as biliary tree obstruction) due to its complex relation with its surrounding structures, current literature seems to suggest that they tend to have good prognostic indices and have a "slow-burning" course [19]. Real world data seem to suggest that RTK inhibitors can benefit patients across the spectrum of performance status and age although little is known about particular cohorts of patients with rare metastatic sites like the pancreas [20].…”