Pancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extract

Cedó, Lídia; Castell-Auví, Anna; Pallarès, Víctor; Ubaida‐Mohien, Ceereena; Baiges, Isabel; Blay, Mayte; Ardévol, Anna; Pinent, Montserrat

doi:10.1016/j.foodchem.2012.06.042

Cited by 14 publications

(16 citation statements)

References 39 publications

(56 reference statements)

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“…Moreover, the results obtained in this study suggested a development of hepatic steatosis in the OZ rats, due to the increase of liver weight and liver TG content, as well as the plasma free fatty acids levels results previously reported (data not shown) . It has been reported that dislipidemic changes occur in obesity and may be due to the increased TG content of the liver due to increased influx of excess free fatty acidss into the liver .…”

Section: Discussionsupporting

confidence: 82%

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Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats

Fernández‐Iglesias

Pajuelo

Quesada

et al. 2013

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 82%

“…Previously, it was confirmed that the experimental OZ rats showed increased body weight [26], hyperinsulinemia [27], and hypertriglyceridemia [9] compared with lean Zucker rats. Therefore, the OZ rat was used as an experimental model for metabolic syndrome.…”

Section: Discussionmentioning

confidence: 83%

Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats

Fernández‐Iglesias

Pajuelo

Quesada

et al. 2013

Molecular Nutrition Food Res

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“…However, there are opposite results showing that grape seed procyanidins improved glucose homeostasis in streptozotocin and high-fat-induced diabetic animal models, 43,44 though no reports provide data of GSPB2 on db/db mice. 16 Our histological results showed that pancreatic islets in db/db mice were much larger than normal ones, possibly implying that they were undergoing the compensatory period. Recently, there is a view that hyperinsulinemia is often both a result and a driver of insulin-resistance, in that rats and humans treated with escalating doses of insulin show insulin resistance.…”

Section: Discussionmentioning

confidence: 62%

“…Tamarind seed extracts with procyanidin content exerted protective effects on pancreatic islets in STZinduced diabetic rats. 15,16 However, in genetic models of diabetes, such as db/db mice, the results of grape seed procyanidin on the pancreas were controversial. In some diet-induced insulin resistant models, grape seed procyanidin exerted favorable effects on modulation of glucose homeostasis and insulin-resistance.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas

Yin

et al. 2015

Food Funct.

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The prevalence of type 2 diabetes mellitus (T2DM) has increased considerably in recent years, highlighting the importance of developing new therapeutic strategies. Insulin-resistance and gradual dysfunction of pancreatic islets are the mainstay in the progression of T2DM. Therefore, preserving the function of the pancreas may lead to new prospective approaches. Our previous studies suggested that grape seed procyanidin B2 (GSPB2), a natural polyphenol product, exhibited protective effects on diabetic vasculopathy. However, effects of GSPB2 on a diabetic pancreas remain unknown. In this study, we provided strong evidence that GSPB2 exerted protective effects on a diabetic pancreas. GSPB2 attenuated the elevated body weights, food intake and advanced glycation end-product (AGE) levels in db/db mice (p < 0.05), though it had no significant effect on glucose levels. The increased islet sizes, insulin levels, as well as HOMA-IR were also improved by GSPB2 treatment in db/db mice (p < 0.05). Milk fat globule epidermal growth factor-8 (MFG-E8), an estimated target of GSPB2 in our previous studies, was up-regulated in pancreatic tissues whereas GSPB2 treatment down-regulated the protein level (p < 0.05). Since MFG-E8 is highly involved in inflammation, we further investigate pro-inflammatory cytokines interleukin-1β (IL-1β) and NLRP3 levels. We found that levels of IL-1β and NLRP3 increased in a diabetic pancreas while GSPB2 treatment notably attenuated these alterations (p < 0.05). In conclusion, our results suggest that inflammation is involved in the damage of a diabetic pancreas and GSPB2 provides protective effects at least in part through anti-inflammation.

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“…After grape seed procyanidin extract administration, the mRNA levels of the anti-apoptotic marker Bcl-2 as well as the ratio Bcl-2/Bax were decreased. Decrease in the expression of cyclin D2 (a marker of proliferation), which was increased in the Zucker fatty rats, was also observed (Cedó et al, 2012). Glucagon-like peptide-1, involved in glucose homeostasis, is another protein that has been inhibited by a grape seed procyanidin extract (González-Abuín et al, 2014).…”

Section: Effects On High Glucose Levelmentioning

confidence: 89%

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

Akaberi

Hosseinzadeh

2016

Phytotherapy Research

116

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Metabolic syndrome is associated with several disorders, including hypertension, diabetes, hyperlipidemia as well as cardiovascular diseases and stroke. Plant-derived polyphenols, compounds found in numerous plant species, play an important role as potential treatments for components of metabolic syndrome. Studies have provided evidence for protective effects of various polyphenol-rich foods against metabolic syndrome. Fruits, vegetables, cereals, nuts, and berries are rich in polyphenolic compounds. Grapes (Vitis vinifera), especially grape seeds, stand out as rich sources of polyphenol potent antioxidants and have been reported helpful for inhibiting the risk factors involved in the metabolic syndrome such as hyperlipidemia, hyperglycemia, and hypertension. There are also many studies about gastroprotective, hepatoprotective, and anti-obesity effects of grape polyphenolic compounds especially proanthocyanidins in the literature. The present study investigates the protective effects of grape seeds in metabolic syndrome. The results of this study show that grape polyphenols have significant effects on the level of blood glucose, lipid profile, blood pressure, as well as beneficial activities in liver and heart with various mechanisms. In addition, the pharmacokinetics of grape polyphenols is discussed. More detailed mechanistic investigations and phytochemical studies for finding the exact bioactive component(s) and molecular signaling pathways are suggested.

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Pancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extract

Cited by 14 publications

References 39 publications

Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats

Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats

Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

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