Pancreatic involvement in systemic sarcoidosis

Romboli, Elisabetta; Campana, Davide; Piscitelli, L; Brocchi, Emilio; Barbara, Giovanni; D’Errico, Antonietta; Fusaroli, Pietro; Corinaldesi, Roberto; Pezzilli, Raffaele

doi:10.1016/j.dld.2003.09.020

Cited by 17 publications

(17 citation statements)

References 27 publications

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“…An autoimmune pathogenesis for this disease has been proposed because this condition is occasionally associated with antibodies or other autoimmune-associated diseases [2, 3, 4, 5, 6, 7, 8, 9]. The terms type 1 and type 2 autoimmune pancreatitis (AIP) have recently been introduced to describe the clinical profiles associated with lymphoplasmacytic sclerosing pancreatitis and idiopathic duct-centric pancreatitis [10].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis

Pezzilli

Vecchiarelli²,

Marco³

et al. 2011

Case Rep Gastroenterol

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Autoimmune pancreatitis (AIP), in contrast to other benign chronic pancreatic diseases, can be cured with immunosuppressant drugs, thus the differentiation of AIP from pancreatic cancer is of particular interest in clinical practice. There is the possibility that some patients with AIP may develop pancreatic cancer, and this possibility contributes to increasing our difficulties in differentiating AIP from pancreatic cancer. We herein report the case of a 70-year-old man in whom pancreatic adenocarcinoma and AIP were detected simultaneously. We must carefully monitor AIP patients for the simultaneous presence of pancreatic cancer, even when a diagnosis of AIP is confirmed.

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Section: Introductionmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis

Pezzilli

Vecchiarelli²,

Marco³

et al. 2011

Case Rep Gastroenterol

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“…In the past few years, pancreatitis due to autoimmunity has not only been reported in Japan, but in the last decade, the frequency of new diagnoses has increased worldwide 1,2 . An autoimmune pathogenesis for this disease has been proposed, because this condition is occasionally associated with antibodies or other autoimmune‐associated diseases 3–9 . Autoimmune pancreatitis (AIP) is characterized by diffuse or focal pancreatic swelling with narrowing of the pancreatic duct and/or common bile duct, and the histological hallmark is lymphoplasmocytic infiltration, which is particularly concentrated in the pancreatic ducts 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

Morselli-Labate

Pezzilli

2009

J of Gastro and Hepatol

126

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High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 patients with AIP and 1099 controls were described in seven selected papers reporting the usefulness of serum IgG4 in diagnosing AIP. In total, 304 controls had pancreatic cancer, 96 had autoimmune diseases, and the remaining 699 had other conditions. The summary receiver-operating characteristic curve analysis was carried out by means of Meta-DiSc open-access software. Serum IgG4 showed good accuracy in distinguishing between AIP and the overall controls, pancreatic cancer and other autoimmune diseases (area under the curve [Ϯ SE]: 0.920 Ϯ 0.073, 0.914 Ϯ 0.191, and 0.949 Ϯ 0.024, respectively). The studies analyzed showed significantly heterogeneous specificity values in each of the three analyses performed. The analysis of the four studies comparing AIP and pancreatic cancers also showed significantly heterogeneous values of sensitivities and odds ratios. Regarding the usefulness of IgG4 as a marker of efficacy of steroid treatment, a decrease in the serum concentrations of IgG4 was found in the four available studies. The serum IgG4 subclass is a good marker of AIP, and its determination should be included in the diagnostic workup of this disease. However, the heterogeneity of the studies published until now means that more studies are necessary in order to better evaluate the true accuracy of IgG4 in discriminating AIP versus other autoimmune diseases.

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“…Интернисты и гастроэнтерологи из Италии описали случай панкреати-ческой гиперэнзимемии в плазме крови как первичное проявление саркоидоза; вовлечение в процесс подже-лудочной железы было подтверждено эндоскопическим ультразвуковым исследованием, которое выявило за-метный железистый фиброз панкреас. Очень важно, что у больного с системным саркоидозом, у которого был повышен в плазме уровень амилазы и липазы, была проведена оценка возможного поражения поджелудоч-ной железы [65].…”

Section: мкб-10unclassified

sarcoidosis and digesTiVe sysTem organs inVol VemenT

Визель¹,

AMIROV²

2010

BCCM

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Pancreatic involvement in systemic sarcoidosis

Cited by 17 publications

References 27 publications

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis

Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

sarcoidosis and digesTiVe sysTem organs inVol VemenT

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