Pancreatic Hormones and Plasma Glucose: Regulation Mechanisms in the Goose under Physiological Conditions - II. Glucose-Glucagon and Glucose-Insulin Feed-Back Mechanisms

A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a nonmetabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5 g/kg) resulted in hyperglucagonaemia, while the same degree of hyperglycaemia, induced by glucose infusion (IV injection 25 mg/kg, and infusion 5 mg/kg/min) immediately suppressed glucagon secretion. In diabetic ducks, two days after subtotal pancreatectomy, glucose responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2 U/kg insulin + 8 micrograms/kg glucagon every 6 h) and during (IV 3.6 mU/kg + infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g/kg). The normal response of the A cell to glucose was not observed in diabetic insulin-treated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of glucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.

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Section: ) Glucose Metabolism and A Cell Responsiveness To Glucosementioning

confidence: 60%

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic a cells in ducks

et al. 1981

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“…A physiological hyperglycaemia induces an increased insulin response and suppresses glucagon secretion, as already shown in the duck with larger amounts of glucose [12], as well as in the goose [30] and in the dog [24], under physiological conditions. The slight hyperglycaemia induced by 2-DG in normal animals is associated with marked hypergtucagonaemia and delayed hyperinsulinaemia, while suppression of glucagon secretion and an immediate increase in B cell response occur in the absence of 2-DG.…”

Section: ) Glucose Metabolism and A Cell Responsiveness To Glucosementioning

confidence: 60%

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks

et al. 1981

Self Cite

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A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a nonmetabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5 g/kg) resulted in hyperglucagonaemia, while the same degree of hyperglycaemia, induced by glucose infusion (IV injection 25mg/kg, and infusion 5 mg/kg/min) immediately suppressed gl.ucagon secretion. In diabetic ducks, two days after subtotal pancreateetomy, gluc6se responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2"U/kg insulin + 8 ~tg/kg glucagon every 6 h) and during (IV 3.6 mU/kg + infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g/kg). The normal response of the A cell to glucose was not observed in diabetic insulintreated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of gtucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.

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“…However, the insulinglucagon molar ratio, which represents metabolic conditions, 18) was found to be related to the order of preference for Junmai-syus (Fig. 4, r 2 ¼ 0:783, p ¼ 0:0657).…”

Section: Hormone Levelmentioning

confidence: 99%

Relationship between the Preference for Sake (Japanese rice wine) and the Movements of Metabolic Parameters Coinciding with Sake Intake

Manabe

Utsunomiya

Gotoh

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Pancreatic Hormones and Plasma Glucose: Regulation Mechanisms in the Goose under Physiological Conditions - II. Glucose-Glucagon and Glucose-Insulin Feed-Back Mechanisms

Cited by 9 publications

References 2 publications

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic a cells in ducks

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic a cells in ducks

Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks

Relationship between the Preference for Sake (Japanese rice wine) and the Movements of Metabolic Parameters Coinciding with Sake Intake

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