Pancreatic hepatocytes

Reddy, Janardan K.; Rao, M. Sambasiva; Yeldandi, Anjana V.; Tan, Xiaodi; Dwivedi, R. S.

doi:10.1007/bf01298883

Cited by 52 publications

(8 citation statements)

References 32 publications

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“…Thus, the generation of hepatocytes from expandable precursors is of considerable interest. It is noteworthy that cells with properties virtually identical to hepatic oval cells can also emerge in the pancreas, especially after ablation of acinar cells (72). Upon transplantation, these pancreas-derived ”oval cells” can differentiate into functional hepatocytes and bile ducts (73).…”

Section: Creating Hepatocytes and β-Cells De Novomentioning

confidence: 99%

Generation and Regeneration of Cells of the Liver and Pancreas

Zaret

Grompe

2008

Science

530

434

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Liver and pancreas progenitors develop from endoderm cells in the embryonic foregut. Shortly after their specification, liver and pancreas progenitors rapidly acquire markedly different cellular functions and regenerative capacities. These changes are elicited by inductive signals and genetic regulatory factors that are highly conserved in vertebrate evolution. Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic β-cells in the therapeutic treatment of liver failure and type I diabetes. Studies in diverse model organisms have revealed evolutionarily conserved inductive signals and transcription factor networks that elicit the differentiation of liver and pancreatic cells, and provide guidance for how to promote hepatocyte and β-cell differentiation from diverse stem and progenitor cell types.

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Section: Creating Hepatocytes and β-Cells De Novomentioning

confidence: 99%

Generation and Regeneration of Cells of the Liver and Pancreas

Zaret

Grompe

2008

Science

530

434

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“…Both tissues may share a common population of progenitor cells [5]. For example, cells with properties virtually identical to those of hepatic oval cells can also emerge in the pancreas, especially after the ablation of acinar cells [6]. Upon transplantation, these pancreas-derived oval cells can differentiate into functional hepatocytes and bile ducts [7].…”

Section: Introductionmentioning

confidence: 99%

Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells

Meivar‐Levy

Sapir

Berneman

et al. 2011

Journal of Transplantation

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Activation of the pancreatic lineage in the liver has been suggested as a potential autologous cell replacement therapy for diabetic patients. Transcription factors-induced liver-to-pancreas reprogramming has been demonstrated in numerous species both in vivo and in vitro. However, human-derived liver cells capable of acquiring the alternate pancreatic repertoire have never been characterized. It is yet unknown whether hepatic-like stem cells or rather adult liver cells give rise to insulin-producing cells. Using an in vitro experimental system, we demonstrate that proliferating adherent human liver cells acquire mesenchymal-like characteristics and a considerable level of cellular plasticity. However, using a lineage-tracing approach, we demonstrate that insulin-producing cells are primarily generated in cells enriched for adult hepatic markers that coexpress both albumin and mesenchymal markers. Taken together, our data suggest that adult human hepatic tissue retains a substantial level of developmental plasticity, which could be exploited in regenerative medicine approaches.

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“…Not even the 2 published papers supporting such hypothesis reported any ectopic normal liver tissue nearby the cancer area [19,20]. Pancreas-to-liver ‘transdifferentiation' has been assessed on animal models since 1991 [21], with many authors focusing on the histogenic mechanism of hepatocyte differentiation in the pancreas of the rat model following copper depletion-repletion [22]. Complete hepatocyte function following the switch has also been described as the pancreas of adult mice contains hepatocyte progenitor cells capable of significant therapeutic liver reconstruction [22].…”

Section: Etiology and Cell Originmentioning

confidence: 99%

Pancreatic Hepatoid Carcinoma: A Review of the Literature

Marchegiani¹,

Gareer²,

Parisi

et al. 2013

Dig Surg

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Background: Hepatoid carcinomas (HCs) are extrahepatic neoplasms exhibiting features of hepatocellular tumors in terms of morphology and immunohistochemistry. They have been described in several organs, most notably in the stomach and ovary. They can present in pure forms or in association with other morphological aspects, such as endocrine tumors or ductal adenocarcinomas. The aim of this review is to describe aspects of hepatoid adenocarcinoma of the pancreas with regard to epidemiology, diagnosis, and treatment. Methods: The PubMed database was searched for publications addressing hepatoid adenocarcinoma of the pancreas. We have searched for articles including the following keywords: ‘pancreatic hepatoid carcinoma', ‘ectopic liver cancer' and ‘rare pancreas neoplasm' published to date. As references, we used case reports and review articles. Results: Pancreatic forms of HCs are extremely uncommon: only 22 cases have been reported. Conclusions: The possibility of an HC of the pancreas should be considered in the differential diagnosis of an uncommon pathological mass of the pancreas. Treatment seems to be related to the association with other neoplasms, tumor extension at the time of diagnosis and the possibility to perform a radical resection. The common embryologic origin of the pancreas and liver, together with peculiar environmental factors, may explain the development of pancreatic HCs.

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Pancreatic hepatocytes

Cited by 52 publications

References 32 publications

Generation and Regeneration of Cells of the Liver and Pancreas

Generation and Regeneration of Cells of the Liver and Pancreas

Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells

Pancreatic Hepatoid Carcinoma: A Review of the Literature

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