Pancreatic GIST in a Patient with Limited Stage Small Cell Lung Cancer: A Case Report and Review of Published Cases

Phan, Minh; Jones, Shari A.; Jenkins, Justin; Pant, Shubham; Khawandanah, Mohamad

doi:10.1155/2016/9604982

Cited by 7 publications

(10 citation statements)

References 47 publications

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“…About 70 % of GISTs involve the stomach and otherwise the small intestine and esophagus, colon and rectum. Duodenal GISTs represent approximately 4% to 5% of all GISTs 2 3 4 . The histopathological features of GISTs include spindle cell (70%) or epithelioid predominance (20%) and otherwise mixed phenotypes 5 .…”

Section: Discussionmentioning

confidence: 99%

“…The histopathological features of GISTs include spindle cell (70%) or epithelioid predominance (20%) and otherwise mixed phenotypes 5 . Immunohistochemistry would be helpful for the diagnosis because GISTs show immunoreactivity for CD117 (95%), CD34 (70%) and DOG-1, which is a complementary stain of CD117 1 2 4 . GISTs are usually benign with a malignant transformation rate of 10~30%1.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

et al. 2018

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We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp. Under the diagnosis with imatinib-resistant duodenal gastrointestinal stromal tumors, a second-line therapy with sunitinib was tried. After six weeks, his skin lesion was completely improved and other metastatic cancers showed a response of stable disease. This is the first reported case of a cutaneous metastasis from duodenal GIST. This report emphasizes the importance of a full-skin examination in patients with a medical history of gastrointestinal stromal tumor which leads to find multiple metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

et al. 2018

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“…5,17-19 In 5 cases the tumor involved the uncinate process of the pancreas located immediately adjacent to the duodenal wall. 20-24 Furthermore, 5 of the tumors reported as pancreatic GISTs also involved stomach, and gastric resection was also performed as part of surgery. 25-29 In most of the remaining cases, the tumors were large well exceeding the dimensions of pancreas.…”

Section: Discussionmentioning

confidence: 99%

GIST Manifesting as a Retroperitoneal Tumor

Miettinen

Felisiak-Gołąbek²,

Wang³

et al. 2017

American Journal of Surgical Pathology

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Most gastrointestinal stromal tumors (GISTs) occur in the tubular gastrointestinal tract, but some present apparently outside the GI-tract. In this study, we analyzed 112 GISTs located in the retroperitoneum. These tumors occurred in 55 women and 57 men with a median age of 65 years (range: 21-89 years). Based on clinically or histologically detected connections to GI-tract, 15 tumors were considered likely of gastric, 9 duodenal, and 13 of small intestinal origin. The remaining cases were categorized by location as peripancreatic (n = 25), pelvic (n = 11), mesenteric (n = 4), and of unspecified/miscellaneous sites (n = 35). The tumors varied in size 3-35 cm (median, 15 cm) and by mitotic rate per 5 mm2, 0- >100 (median 10). Histologically the tumors apparently arising outside the GI-tract had features of intestinal (n = 41) and gastric GISTs (n = 25); 9 cases had indeterminate histology. The histologic variants included spindled, epithelioid, vacuolated, nested and myxoid potentially simulating other tumors such as liposarcoma and solitary fibrous tumor. Most GISTs were KIT-positive (106/112 cases), and the remaining 6 tumors were Dog1/Ano1-positive. Five cases showed focal nuclear positivity for MDM2. KIT mutations were detected in 42/59 cases, and PDGFRA mutations in 4/16 KIT wild-type and 3/5 of the KIT-negative tumors analyzed. One pelvic retroperitoneal GIST was SDH-deficient. All 79 patients were dead at last follow-up with a median survival of 14 months, with few survivals > 5 years. Only operable vs. inoperable tumor was a statistically favorable factor in univariate analysis (p<0.01). In multivariate analysis, mitotic rate > 50/5 mm2 was significant for a shorter survival (HR 5.25, 95% CI 1.65-16.8., p<0.01). Histologic and clinicopathologic similarity of extragastrointestinal retroperitoneal GISTs with GISTs of GI-tract suggests their GI tract origin. Potentially overlapping features between GIST and other retroperitoneal tumors necessitate use of multiple diagnostic markers and molecular genetic studies.

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“…The most frequent site of GIST is the stomach (60%), followed by the small intestine (35%) and the colon and rectum (< 5%)[ 1 ]. Immunohistochemistry is helpful for the diagnosis because GISTs show immunoreactivity for CD117 (95%), CD34 (70%), and DOG1, a complementary marker to CD117[ 2 ]. GISTs are usually benign with a malignant transformation rate of 10-30%.…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic focal segmental glomerulosclerosis associated with gastrointestinal stromal tumor with cutaneous metastasis: A case report

Zhou¹,

Yang²,

Yang³

et al. 2021

WJCC

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BACKGROUND Gastrointestinal stromal tumor (GIST) with cutaneous metastasis is very rare. As a result, cutaneous GISTs have not been well characterized. Focal segmental glomerulosclerosis (FSGS) is also a rare symptom among paraneoplastic nephritic syndromes (PNS). CASE SUMMARY In this case report, we describe a patient with cutaneous metastatic GIST accompanied by nephrotic syndrome occurring as a malignancy-associated PNS, for whom symptomatic treatment was ineffective, but clinical remission was achieved after surgery. Moreover, the patient has a missense mutation in NPHP4 , which can explain the occurrences of GIST and FSGS in this patient and indicates that the association is not random. CONCLUSION This is the first reported case of a GIST with cutaneous metastasis accompanied by nephrotic syndrome manifesting as a PNS.

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Pancreatic GIST in a Patient with Limited Stage Small Cell Lung Cancer: A Case Report and Review of Published Cases

Cited by 7 publications

References 47 publications

Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

GIST Manifesting as a Retroperitoneal Tumor

Paraneoplastic focal segmental glomerulosclerosis associated with gastrointestinal stromal tumor with cutaneous metastasis: A case report

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