Pancreatic Fungal Infections

Robbins, Earl G.; Stollman, Neil; Bierman, Paul R.; Grauer, L.; Barkin, Jamie S.

doi:10.1097/00006676-199604000-00016

Cited by 28 publications

(2 citation statements)

References 10 publications

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“…Only a small number of patients in our series suffered from infection with Candida albicans, which is regarded as the most virulent member of the Candida family. Nevertheless, review of the literature shows that most intraabdominal [10] or pancreatic infections [11,[17][18][19] with Candida are caused by organisms classified as Candida species, not Candida albicans.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Infection with Candida Species inPatients with Necrotizing Pancreatitis

et al. 2002

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This study focuses on the relevance of Candida infection (albicans and non-albicans) in patients with necrotizing pancreatitis. Altogether, 92 patients with infected pancreatic necrosis were reviewed for Candida infection. All patients underwent surgical necrosectomy for infected pancreatic necrosis. Data from patients with Candida growth in intraoperative smears were compared to those obtained from patients without Candida infection. There were 22 patients (24%) with Candida infection. Patients with or without Candida infection were comparable regarding age, gender, etiology, and severity scores at admission. Candida patients suffered a higher mortality (64% vs.19%, p = 0.0001) and experienced more systemic complications (3.2 +/- 1.6 vs. 2.1 +/- 1.4; p= 0.004) than patients without Candida. Preoperative antibiotics were given significantly longer prior to Candida infection (19.0 +/- 13.2 vs. 6.4 +/- 10.3 days; p < 0.0001). With regard to the concomitant spectrum of bacteria, solitary gram-negative infection was rare in Candida patients (5% vs. 43%, p =0.0006). The presence of Candida in patients with infected pancreatic necrosis is associated with increased mortality. Our data provide evidence that application of antibiotics contributes to the development of Candida infection and to changes in the bacterial spectrum of infected necrosis with an increase in the incidence of gram-positive infection.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Infection with Candida Species inPatients with Necrotizing Pancreatitis

et al. 2002

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“…[ 36 ] Earlier debridement is associated with higher mortality, [ 8 , 12 , 16 , 44 ] whereas longer delay in intervention may imply overuse of antibiotics, leading to increased incidence of resistant bacteria and the emergence of fungi and other opportunistic microorganisms, all associated with prolonged ICU stay and increased mortality. [ [45] , [46] , [47] ]…”

Section: Discussionmentioning

confidence: 99%