Pancreatic Function and Disease in Early Life. I. Pancreatic Enzyme Activity and the Celiac Syndrome 1

CFTR, Mucins, and Mucus Obstruction in Cystic Fibrosis

“…Cystic fibrosis is often referred to as "mucoviscidosis" in early descriptions of the disease (Farber et al 1943) because copious amounts of viscid mucus were observed in the gastrointestinal and respiratory tracts of children when the disease was first reported in 1938 (Anderson 1938). Mucus is a viscoelastic material that covers and protects the apical surfaces of the respiratory, gastrointestinal, and reproductive epithelial tracts and is a composite of components secreted apically (luminally) by epithelial and glandular cells in the mucosal epithelium .…”

Studies in Coeliac Disease: Fat Absorption

“…We have, however, been able to confirm the finding of Farber et al (1943), that the production of lipase in the duodenal contents of coehac children is normal, and there is no reason to suppose that the action of this enzyme is defective.…”

Serum Protein Pattern in Infants with Nutritional Disorders

“…From reports dealing with infants with other conditions it appears that pancreatic enzymatic activity is often depressed in acute and chronic diarrhoea and sometimes during respiratory infections. This depression is often selective, one enzyme being present in normal amounts whilst the other two show lowered values or are absent (Hess, 1913;Davison, 1925;Farber, Schwachman and Maddock, 1943;McDougall, 1950). This demonstrates the need to examine the activity of all three pancreatic enzymes in the duodenal juice in suspicious cases and not to rely merely on a trypsin estimation as is the procedure in many centres.…”