Pancreatic fat content assessed by ¹H magnetic resonance spectroscopy is correlated with insulin resistance, but not with insulin secretion, in Japanese individuals with normal glucose tolerance

Abstract

Aims/IntroductionWhereas some clinical studies have shown that excessive fat accumulation in the pancreas is associated with impairment of insulin secretion, others have not found such an association. 1H magnetic resonance spectroscopy allows quantitative fat analysis in various tissues including the pancreas. The pathological relevance of pancreatic fat content (PFC) in Japanese individuals remains unclear, however.Materials and MethodsWe analyzed PFC in 30 Japanese individuals with normal glucose tolerance by 1H magnetic resonance spectroscopy, and then investigated the relationships between PFC and indexes of insulin secretion and insulin sensitivity‐resistance determined by an oral glucose tolerance test. We also measured hepatic fat content and intramyocellular lipid content by 1H magnetic resonance spectroscopy, as well as visceral fat area and subcutaneous fat area by magnetic resonance imaging, and we examined the relationships between these fat content measures and oral glucose tolerance test‐derived parameters.Results PFC was correlated with indexes of insulin sensitivity‐resistance, but not with those of insulin secretion. Hepatic fat content and visceral fat area were correlated with similar sets of parameters as was PFC, whereas subcutaneous fat area was correlated with parameters of insulin secretion, and intramyocellular lipid content was not correlated with any of the measured parameters. The correlation between PFC and homeostasis model assessment of insulin resistance remained significant after adjustment for age, body mass index and sex. Among fat content measures, PFC was most highly correlated with hepatic fat content and visceral fat area.Conclusions PFC was correlated with indexes of insulin resistance, but not with those of insulin secretion in non‐obese Japanese individuals with normal glucose tolerance.

Magnetic resonance imaging: Proton density fat fraction for assessment of pancreatic fatty infiltration during progression of T2DM bama minipigs

“…Frequently, nonuniform deposits may cause difficulties for pancreatic biopsy. Notably, the reproducibility of PFF measurements in this study was similar to those of PFC, as assessed by 1 H MR spectroscopy . Additionally, Bland–Altman plots showed good agreement of PFF measurements between the two interobservers in the present study.…”

“…Notably, the reproducibility of PFF measurements in this study was similar to those of PFC, as assessed by 1 H MR spectroscopy. 28 Additionally, Bland-Altman plots showed good agreement of PFF measurements between the two interobservers in the present study. Our results are consistent with Bray et al, who show that fat fraction (FF, the proportion of the acquired signal derived from fat protons) has become established as a clinical and research tool.…”

Treatment of a case of severe insulin resistance as a result of a PIK3R1 mutation with a sodium–glucose cotransporter 2 inhibitor

“…Her height was 143 cm, bodyweight 38 kg and body mass index 18.6 kg/m 2 . Her visceral and subcutaneous fat areas assessed by abdominal magnetic resonance imaging were 57 and 95 cm 2 , respectively, which were comparable with those observed in non‐obese, young, normoglycemic individuals . She had a triangular face, prominent forehead, small chin, large and low‐set ears, and ocular depression (Figure ), but not hyperextensibility of the joints or Rieger anomaly.…”

Na dobre i na złe – czyli rola oddziaływania trzustki, śródbłonka i tkanki tłuszczowej w regulacji funkcjonowania komórek β i rozwoju cukrzycy typu 2 związanej z otyłością

“…Accumulation of lipid species within exocrine or endocrine pancreas and in β-cells is associated with parenchymal or pancreatic steatosis [5]. This association, however, is confounded by the elevated levels of visceral adipose tissue (VAT) [7]. The accumulation of TGs in the pancreas in mice that were fed a high-fat (HF) diet and islets in obese leptin-deficient rats increased relative to control lean littermates during the transition from prediabetes to diabetes [8,9].…”

“…Although the direct imaging of β-cells is impossible in humans, the structure and chemical composition of the pancreas can be studied by combining several noninvasive modalities, including computed tomography, ultrasound, magnetic resonance imaging, and magnetic resonance spectroscopy [6,7,10]. Larger fat deposits were observed in the body and tail than in the head of the pancreas [11].…”