Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

Avante, Lopes Michelle; Feliciano, Marcus Antônio Rossi; Ramírez, U Ricardo; Cristina, M.; Aguila, Silva Priscila Del; Pozzobon, Ricardo; Rodrigues, Sílvia Adriana; Silva, Priscila; Gasser, Beatriz; Pavan, Letícia; Nogueira, Aires Luiz Paulo; Carlos, Canola Júlio

doi:10.2478/acve-2020-0018

Cited by 4 publications

(9 citation statements)

References 23 publications

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“…Diseased tissues can have different stiffness values when compared to healthy tissues, and specific software packages can detect these differences. Elastography recently was investigated in 25 dogs, including 9 with suspected AP based on clinical signs, abdominal discomfort and clinicopathologic data 125 . Shear wave velocity was higher in dogs with suspected AP than in the control group 125 …”

Section: Diagnostic Imagingmentioning

confidence: 99%

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Advances in the diagnosis of acute pancreatitis in dogs

Cridge

Twedt

Marolf

et al. 2021

Veterinary Internal Medicne

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In the last 20 years, the diagnosis of pancreatitis has become more frequent as a result of improved diagnostic modalities such as abdominal ultrasound examination, advanced imaging, and immunoassays for the measurement of pancreatic lipase. Our aim is to provide a state‐of‐the‐art overview of the clinical diagnosis of acute pancreatitis (AP) in dogs with a particular focus on pancreatic lipase assay validation and clinical performance, in addition to advanced imaging modalities. We also discuss the potential indications for cytology and histopathology in dogs with suspected AP.

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Section: Diagnostic Imagingmentioning

confidence: 99%

“…Elastography recently was investigated in 25 dogs, including 9 with suspected AP based on clinical signs, abdominal discomfort and clinicopathologic data 125 . Shear wave velocity was higher in dogs with suspected AP than in the control group 125 …”

Section: Diagnostic Imagingmentioning

confidence: 99%

Advances in the diagnosis of acute pancreatitis in dogs

Cridge

Twedt

Marolf

et al. 2021

Veterinary Internal Medicne

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“…Recently, 2D SWE confirmed that the SWS in dogs with clinically relevant hepatic fibrosis was significantly higher compared to those in healthy dogs and dogs without clinically relevant hepatic fibrosis ( Tamura et al, 2019b ). In addition, 2D SWE revealed the different SWS in dogs with suspected pancreatic diseases and clinically healthy dogs ( Avante et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Two-Dimensional Shear Wave Elastography of Normal Soft Tissue Organs in Adult Beagle Dogs; Interobserver Agreement and Sources of Variability

Jung

Lee

et al. 2020

Front. Bioeng. Biotechnol.

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Shear wave elastography (SWE) induces lateral shear wave through acoustic pulses of the transducer and evaluates tissue stiffness quantitatively. This study was performed to evaluate feasibility and reproducibility of two-dimensional shear wave elastography (2D SWE) for evaluation of tissue stiffness and to examine technical factors that affect shear wave speed (SWS) measurements in adult dogs. Nine healthy, 2 yearold, adult beagles with the median weight of 9.8 kg were included. In this prospective, experimental, exploratory study, 2D SWE (Aplio 600) from the liver, spleen, kidneys, pancreas, prostate, lymph nodes (submandibular, retropharyngeal, axillary, medial iliac, and inguinal), submandibular salivary gland, and thyroid was performed in anesthetized beagles. Color map was drawn and SWS of each SWE were measured as Young's modulus (kPa) and shear wave velocity (m/s). The effect of measuring site, scan approach, depth, and anesthesia on SWE was assessed in abdominal organs by two observers independently. A total of 27 SWE examinations were performed in 12 organs by each observer. All SWS measurements were preformed successfully; however, SWE in the renal medulla could not be successfully conducted, and it was excluded from further analysis. Interobserver agreement of SWE was moderate to excellent in all organs, except for the left liver lobe at 10-15 mm depth with the intercostal scan. In the liver, there was no significant effect of the measuring site and scan approach on SWE. SWS of the liver and spleen tended to be higher with increasing the depth, but no significant difference. However, anesthesia significantly increased tissue stiffness in the spleen compared to awake dog regardless of the depth (P < 0.05). There was a significant difference in SWS according to the measuring site in the kidneys and pancreas (P < 0.001). 2D SWE was feasible and highly reproducible for the estimation of tissue stiffness in dogs. Measuring site and anesthesia are sources of variability affecting SWE in abdominal organs. Therefore, these factors should be considered during SWS measurement in 2D SWE. This study provides basic data for further studies on 2D SWE on pathological conditions that may increase tissue stiffness in dogs.

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“…2-D SWE successfully differentiated artificially ablated lesions of the liver ( 17 ) and spontaneous hepatic fibrosis of the liver ( 18 ) from the normal parenchyma in dogs, with a significant increase in stiffness value discovered. The shear-wave velocity was increased in dogs with pancreatic disease ( 19 ). The stiffness of the renal cortex and medulla was significantly higher in cats with chronic kidney disease than in normal cats ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Reliability of Two-Dimensional Shear-Wave Elastography of the Liver of Clinically Healthy Cats

Kim

Lee

et al. 2020

Front. Vet. Sci.

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Given the broad overlap of normal and abnormal liver tissue in the subjective evaluation of the liver in conventional B-mode ultrasonography, there is a need for a non-invasive and quantitative method for the diagnosis of liver disease. Novel two-dimensional shear-wave elastography (2-D SWE) can measure tissue stiffness by propagation of the shear wave induced using acoustic radiation force impulse in real time. To the best of our knowledge, two-dimensional shear-wave measurement of the liver in cats has not been reported to date. This study assessed the feasibility, reliability, normal values, and related influencing factors of 2-D SWE for assessment of the feline liver without anesthesia and breath-holding. Two-dimensional shear-wave ultrasonography was performed by two evaluators at the right and left sides of the liver. Twenty-nine client-owned clinically healthy adult cats were included. The means and standard deviations for the shear-wave speed and stiffness in the right liver were 1.52 ± 0.13 m/s and 6.94 ± 1.26 kPa, respectively, and those for the left liver were 1.61 ± 0.15 m/s and 7.90 ± 1.47 kPa, respectively. Shear-wave speed (P = 0.005) and stiffness (P = 0.002) were significantly lower in the right liver when compared to the left. The intraclass correlation value for liver stiffness was 0.835 and 0.901 for the right and left liver, respectively, indicating high interobserver agreement. Age, weight, body condition score (BCS), gabapentin administration, and measurement depths were not significantly correlated with liver stiffness or elastography measurements (P > 0.05). Our findings suggest that 2-D SWE measurements of the liver are not influenced significantly by age, weight, or BCS and can be reliably performed without anesthesia and breath-holding in cats. The values determined here can help form the basis for reference elastography values for evaluation of the feline liver.

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Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

Cited by 4 publications

References 23 publications

Advances in the diagnosis of acute pancreatitis in dogs

Advances in the diagnosis of acute pancreatitis in dogs

Two-Dimensional Shear Wave Elastography of Normal Soft Tissue Organs in Adult Beagle Dogs; Interobserver Agreement and Sources of Variability

Feasibility and Reliability of Two-Dimensional Shear-Wave Elastography of the Liver of Clinically Healthy Cats

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