Pancreatic Enzyme and Plasma Cholesterol Response to Chronic Ingestion of a Nonabsorbable Lipid in Rats

Häger, M; Schneeman, Barbara O.

doi:10.1093/jn/116.12.2372

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others have reported differences in the acceptability of solid and liquid, digestible and indigestible oils in rats as described in the introduction. Our results with the LTAG and SA diets are consistent with other reports showing acceptability of diets containing either palm oil [e.g., 22,23], or non-digestible oil-like substances [14][15][16][17], respectively.…”

Section: Resultssupporting

confidence: 92%

“…Instead, SA intakes were comparable to LTAG. In a study in which fatty acid deficiency was not present, the presence of 4% hydrogenated palm oil did not result in reduced intake [15]. The present study indicates that at a higher concentration, hydrogenated palm oil is not acceptable to rats, although the reason for that remains unclear.…”

Section: Resultscontrasting

confidence: 52%

“…The fats selected were palm oil and hydrogenated palm oil as examples of liquid and solid triacylglycerols (digestible fats) and docosane as a solid indigestible fat. Others have shown that rats will readily consume digestible and non-digestible fats and fat-like substances [14][15][16][17]. Nutritive fats and non-nutritive greasy substances are acceptable to rats [e.g.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acceptability and Digestibility of Emulsions in a Rat Model: Effects of Solid Fat Content and Lipid Type

Wang

Corwin

Jaramillo

et al. 2010

J Americ Oil Chem Soc

View full text Add to dashboard Cite

The present study sought to determine if alterations in the chemical nature and form of fat in food would reduce digestibility while maintaining acceptability in rats. Oil-in-water emulsions (d \ 1 lm) were prepared with either liquid palm oil, solid hydrogenated palm oil or solid docosane, all stabilized with sodium caseinate. The emulsions were incorporated into a fat-free rodent feed, and each offered over 5 days to separate cohorts of 12 male Sprague-Dawley rats housed in metabolic cages. The feed formulated with solid hydrogenated palm oil was significantly less acceptable than the feeds containing either liquid palm oil or docosane (feed intake 4.9, 26.6 and 32.1 g/animal/day respectively). The proportion of the fat retained (i.e. absorbed) was significantly less in the animals consuming the feed formulated with solid docosane than in the animals consuming either the liquid or solid palm oil (retention 8.7, 99.6, and 97.2%, respectively). The appearance of the feces from the rats fed docosane was different from the rats fed the triacylglycerol samples and thermal analysis revealed many of the solid alkane droplets had not coalesced during passage through the rat's digestive system. These results indicate that indigestible fats can be packaged into food in a manner that does not compromise the acceptability of the product, and does not produce any apparent intestinal distress.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultscontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acceptability and Digestibility of Emulsions in a Rat Model: Effects of Solid Fat Content and Lipid Type

Wang

Corwin

Jaramillo

et al. 2010

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

“…The question of whether the pancreas responds to olestra as a digestible dietary lipid or as a non‐nutritive ingredient was studied by Hager & Schneeman 52 . Adult rats were assigned to groups fed diets containing 5% corn oil, 20% corn oil, 16% corn oil plus 4% hydrogenated palm oil (HPO), 5% SPE, or 16% SPE plus 4% HPO for 28 days.…”

Section: Pancreatic Enzymesmentioning

confidence: 99%

Review article: olestra and its gastrointestinal safety

Thomson

Hunt

Zorich

1998

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Olestra is a fat substitute made from sucrose and vegetable oil. Olestra is neither digested nor absorbed, and therefore adds no calories or fat to the diet. Because the gut is the only organ that is exposed to olestra, the potential for olestra to affect gastrointestinal structure and function, and the absorption of nutrients from the gut, has been investigated. Histological evaluations performed after long-term feeding studies have shown no indications that olestra causes injury to the gastrointestinal mucosa. Olestra is not metabolized by the colonic microflora, and has no meaningful effects on the metabolic function of these organisms. Studies of gastrointestinal transit have shown that the consumption of olestra with food does not affect gastric emptying, or small or large bowel transit times. Olestra does not affect the absorption of macronutrients, water-soluble vitamins or minerals. It causes a dose-responsive decrease in the availability of the fat-soluble vitamins A, D, E and K; however, this potentially adverse effect is offset by the addition of vitamins to olestra-containing foods. Olestra has no consistent effect on the amount of total bile acids excreted in the faeces, and therefore probably has no significant effect on bile acid absorption. The occurrence of gastrointestinal symptoms, including diarrhoea, loose stools, gas and abdominal cramping, after consumption of olestra under ordinary snacking conditions is comparable to that following consumption of triglyceride-containing snacks.

show abstract

Olestra formulation and the gastrointestinal tract

Jandacek

Kester

Papa

et al. 1999

Lipids

View full text Add to dashboard Cite

Olestra is a mixture of compounds comprising sucrose esterified with 6-8 long-chain fatty acids. It is not hydrolyzed by pancreatic lipase and as a result is not absorbed from the small intestine. Olestra in general has physical properties similar to those of a triacylglycerol with the same fatty acid composition. Foods made with olestra are virtually identical in taste and texture to those made with typical triacylglycerols. Olestra consumption does not generate hydrolytic products in the small intestine and, therefore, does not generate some of the signals that alter motility in the gastrointestinal tract. A reduction in gastroesophageal reflux with olestra, in contrast to triacylglycerols, is consistent with a lack of effect on stomach emptying. Unlike triacylglycerols that are absorbed in the proximal small intestine, olestra is distributed throughout the small intestine during transit and passes into the colon. In the colon, olestra's effects depend on its physical properties. Liquid nondigestible lipids result in separation of oil from the fecal matrix. Olestra formulations made with specific fatty acid compositions, particularly those containing a solid sucrose polyester component including behenic acid, possess appropriate rheology to hinder separation of oil from the rest of the fecal matrix, thereby reducing gastrointestinal symptoms.

show abstract

Pancreatic Enzyme and Plasma Cholesterol Response to Chronic Ingestion of a Nonabsorbable Lipid in Rats

Cited by 9 publications

References 11 publications

Acceptability and Digestibility of Emulsions in a Rat Model: Effects of Solid Fat Content and Lipid Type

Acceptability and Digestibility of Emulsions in a Rat Model: Effects of Solid Fat Content and Lipid Type

Review article: olestra and its gastrointestinal safety

Olestra formulation and the gastrointestinal tract

Contact Info

Product

Resources

About