Pancreatic Endocrine Tumors

ppel, G nter Kl; Anlauf, Martin

doi:10.1097/01.pcr.0000251146.82702.2d

Cited by 11 publications

(2 citation statements)

References 154 publications

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“…The pancreatic endocrine tumors were previously called "islet cell tumors of pancreas". This nomenclature is no longer used in recent publications due to accumulated evidence that they originate from ductal pancreatic stem cells [6]. It is believed that endocrine cells of the pancreas differentiate from the primitive epithelial ductal cells that…”

Section: Discussionmentioning

confidence: 99%

A Patient with a Pancreatic Endocrine Tumor develops Chronic Schizophrenia: Report of a Case

Hood¹

2013

J Clin Case Rep

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Section: Discussionmentioning

confidence: 99%

A Patient with a Pancreatic Endocrine Tumor develops Chronic Schizophrenia: Report of a Case

Hood¹

2013

J Clin Case Rep

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“…A recently reported series of Pan‐NETs diagnosed by EUS‐FNA included only 7/81 (8.6%) functional Pan‐NETs (three gastrinomas and four insulinomas) . Small amounts of amyloid can be seen in 5–25% of functioning Pan‐NETs as the result of the deposition of amylin, also referred to as islet amyloid polypeptide. Amyloid deposition usually occurs in younger patients with insulinomas and is associated with good prognosis.…”

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confidence: 99%

Psammoma bodies and abundant stromal amyloid in an endoscopic ultrasound guided fine needle aspirate (EUS‐FNA) of a pancreatic neuroendocrine tumor: A potential pitfall

Samad

Attam

Jessurun

et al. 2013

Diagnostic Cytopathology

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A 42-year-old male presented to our institution with a 2-month history of several episodes of confusion, double vision, headache, and loss of consciousness. The blood glucose levels measured during these episodes were in the range of 30-40 mg/dl, but randomly drawn blood samples showed normal glucose levels. Further workup showed a fasting blood glucose level of 34 mg/dl at 60 hours and elevated proinsulin levels, while insulin and C-peptide levels were normal. Serum levels of chromogranin A, pancreatic polypeptide, sulfonylurea, human growth hormone, cortisol, TSH, calcium, and creatinine were within normal limits. Computed tomography scan of the head, thorax and abdomen demonstrated no abnormal findings. The patient underwent endoscopic ultrasound evaluation, which showed a round, hypoechoic lesion measuring 14 3 13 mm in the body of the pancreas. Three transgastric EUS-FNA passes of the pancreatic lesion were performed using a 22 gauge needle. The aspirated material was used for the preparation of three airdried rapid Romanowsky (Diff-Quik V R ) stained smears, three paired fixed smears, to be later stained with the Papanicolaou stain, and the remaining material was placed in 10% formalin for cell block preparation. The FNA samples were deemed adequate during rapid onsite evaluation of the Diff-Quik V R -stained smears but a specific diagnosis was deferred to the examination of the alcoholfixed Papanicolaou-stained smears and hematoxylin and eosin stained cell block sections.The smears were hypocellular, but showed abundant large (0.2-0.6 mm) arborizing fragments of amorphous material in a "dirty" background composed of fragments of amorphous debris, red blood cells, proteinaceous material, wisps of mucus and occasional single cells and naked nuclei (Fig. C-1). In Diff-Quik V R -stained smears

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Investigation of human pancreatic cancer tissues by Fourier Transform Infrared Hyperspectral Imaging

Notarstefano

Conti

Pisani

et al. 2019

Journal of Biophotonics

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Fourier-transform infrared hyperspectral imaging (FTIR-HSI) provides hyperspectral images containing both morphological and chemical information. It is widely applied in the biomedical field to detect tumor lesions, even at the early stage, by identifying specific spectral biomarkers. Pancreatic neoplasms present different prognoses and are not always easily classified by conventional analyses. In this study, tissue samples with diagnosis of pancreatic ductal adenocarcinoma and pancreatic neuroendocrine tumor were analyzed by FTIR-HSI and the spectral data compared with those from healthy and dysplastic samples. Multivariate/univariate approaches were complemented to hyperspectral images, and definite spectral markers of the different lesions identified. The malignant lesions were recognizable both from healthy/dysplastic pancreatic tissues (high values of phospholipids and triglycerides with shorter, more branched and less unsaturated alkyl chains) and between each other (different amounts of total lipids, phosphates and carbohydrates). These findings highlight different metabolic pathways characterizing the different samples, well detectable by FTIR-HSI. K E Y W O R D SFourier transform infrared hyperspectral imaging, multivariate analysis, pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumors, spectral biomarkers

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Pancreatic Endocrine Tumors

Cited by 11 publications

References 154 publications

A Patient with a Pancreatic Endocrine Tumor develops Chronic Schizophrenia: Report of a Case

A Patient with a Pancreatic Endocrine Tumor develops Chronic Schizophrenia: Report of a Case

Psammoma bodies and abundant stromal amyloid in an endoscopic ultrasound guided fine needle aspirate (EUS‐FNA) of a pancreatic neuroendocrine tumor: A potential pitfall

Investigation of human pancreatic cancer tissues by Fourier Transform Infrared Hyperspectral Imaging

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