2011
DOI: 10.1158/0008-5472.can-10-4439
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Pancreatic Ductal Adenocarcinoma Mice Lacking Mucin 1 Have a Profound Defect in Tumor Growth and Metastasis

Abstract: MUC1 is over expressed and aberrantly glycosolated in >60% of pancreatic ductal adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully elucidated due to a dearth of appropriate models. In the present study, we have generated mouse models that spontaneously develop pancreatic ductal adenocarcinoma (KC), which are either Muc1-null (KCKO) or express human MUC1 (KCM). We show that KCKO mice have significantly slower tumor progression and rates of secondary metastasis, compared to bot… Show more

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Cited by 110 publications
(144 citation statements)
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“…Regardless of treatment, most KCKO tumors never grew as large as the KCM tumors. This observation is in agreement with previous studies in which mice bearing KCKO tumors present a less-challenging, more-stable form of PDA disease as the cells grow at a lower rate than the more aggressive KCM cells (7).…”
Section: Susceptibility Of Murine Pda Cells To Vsvsupporting
confidence: 93%
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“…Regardless of treatment, most KCKO tumors never grew as large as the KCM tumors. This observation is in agreement with previous studies in which mice bearing KCKO tumors present a less-challenging, more-stable form of PDA disease as the cells grow at a lower rate than the more aggressive KCM cells (7).…”
Section: Susceptibility Of Murine Pda Cells To Vsvsupporting
confidence: 93%
“…MUC1 is overexpressed and aberrantly glycosylated in more than 80% of human PDAs and in 100% of metastatic lesions (5). It not only plays an important role in development and progression of PDA and other cancers but also is a major marker of poor prognosis, and its expression often confers resistance of cancer cells to chemotherapeutics (7,8,11). In general, our data suggest that VSV is tolerant to the expression of MUC1, at least in the tested PDA cell lines.…”
Section: Discussionsupporting
confidence: 50%
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“…The mucins may prevent drugs from accessing their sites of action. The expression of several mucins, including MUC1, MUC4, MUC5AC, and MUC16, is highly upregulated in pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN), intrapapillary mucinous neoplasms, and mucinous cystic neoplasms from patients with pancreatic cancer (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The extent to which the dense mucin mesh influences the antiproliferative activity of 5-fluorouracil (5-FU) was investigated using human pancreatic cancer cells (2,3).…”
Section: Introductionmentioning
confidence: 99%