Pancreatic Ductal Adenocarcinoma Derived From IPMN and Pancreatic Ductal Adenocarcinoma Concomitant With IPMN

Yamaguchi, Koji; Shirasuna, Kanemitsu; Hatori, Takashi; Maguchi, Hiroyuki; Shimizu, Yasuhiro; Tada, Minoru; Nakagohri, Toshio; Hanada, Keiji; Osanai, Manabu; Noda, Yutaka; Nakaizumi, Akihiko; Furukawa, Toru; Ban, Shinichi; Nobukawa, Bunsei; Kato, Yukio; Tanaka, Masao

doi:10.1097/mpa.0b013e318215010c

Cited by 238 publications

(135 citation statements)

References 17 publications

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“…17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 These studies demonstrated that the frequency of PC concomitant with IPMN ranged from 1.1% to 11.2%. As for branch duct IPMN, two working groups of JPS reported that seven PC cases were detected in 349 branch duct IPMN cases during the follow‐up period,17 and that PC concomitant with IPMN may be diagnosed earlier than ordinary PC 18. These observations suggest that patients with IPMN or pancreatic cysts should be carefully observed as having premalignant disease of PC.…”

Section: Risk Factors and Early Diagnosismentioning

confidence: 85%

Early diagnosis of pancreatic cancer: Current trends and concerns

Hanada

Amano

Abe

2017

Annals of Gastroent Surgery

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Early detection of pancreatic cancer (PC) is essential for a better prognosis. Some recent studies have demonstrated that a slight dilatation of the main pancreatic duct (MPD) and small cystic lesions were detected initially in most cases diagnosed at an early stage. Detecting these abnormal findings in cases with high risk factors through an effective screening system including image diagnosis, some biological markers, or familial cancer registrations should contribute to early diagnosis of PC. It has been reported that endoscopic ultrasonography (EUS) is essential for detecting tumors <10 mm with a favorable prognosis. Additionally, EUS‐guided fine‐needle aspiration biopsy is useful for confirming final histological diagnosis. For the diagnosis of stage 0 PC, local irregular stenosis of MPD should be an important initial abnormal sign detected by EUS or magnetic resonance cholangiopancreatography. Cytodiagnosis multiple times using pancreatic juice obtained by endoscopic nasopancreatic drainage should be essential for the final diagnosis. Recently, activities of regional networks between specialist doctors in medical centers and general practitioners for early diagnosis of PC have been reported in Japan. In the future, these activities may play an important role in the early diagnosis of PC.

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Section: Risk Factors and Early Diagnosismentioning

confidence: 85%

Early diagnosis of pancreatic cancer: Current trends and concerns

Hanada

Amano

Abe

2017

Annals of Gastroent Surgery

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“…Yamaguchi et al reported that IPMN is sometimes concomitant with invasive pancreatic carcinoma (11). A search of PubMed revealed no other reports similar to the present case.…”

Section: Discussionmentioning

confidence: 55%

Undifferentiated Carcinoma of the Pancreas Involving Intraductal Pedunculated Polypoid Growth

et al. 2012

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We herein report a case of pancreatic undifferentiated carcinoma involving intraductal pedunculated polypoid growth. Duodenoscopy disclosed a congested polypoid mass protruding from the orifice of the papilla of Vater. Endoscopic retrograde pancreatography (ERP) showed a polypoid lesion in Wirsung's duct and Santorini's duct. Pancreatic juice cytology using the cell block method revealed the presence of undifferentiated carcinoma. No extraductal invasion was detected on endoscopic ultrasonography and or intraductal ultrasonography. The patient therefore underwent pancreaticoduodenectomy. A histological examination revealed an intraductal polypoid tumor with a thin stalk without extraductal invasion. The tumor was composed of an abundant mixture of pleomorphic cells, spindle cells, giant cells, and a small amount of adenocarcinoma.

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“…From these reports, the guidelines recommended that IPMNs and pancreatic cysts should be carefully followed as premalignant diseases of PC [6]. Additionally, another JPS working group reported that PC concomitant with IPMN may have more favorable biological behaviors or may be diagnosed earlier than ordinary PC [11]. These reports suggest that the regular follow-up of IPMN patients may play an important role in the early diagnosis of PC.…”

Section: Risk Factors For Pcmentioning

confidence: 98%