Pancreatic Duct Occlusion with Fibrin Sealant for the Protection of the Pancreatic-Digestive Anastomosis Following Resection of the Pancreatic Head (Experimental and Clinical Study)

RETRACTED: The Role of Pancreatic Leakage on Rising of Postoperative Complications Following Pancreatic Surgery

“…Gall et al [15] found similar results with duct occlusion after Whipple's operation in patients with chronic pancreatitis. Lorenz et al [16] noted fewer early complications in oncologic pancreatic surgery, but not in patients with chronic pancreatitis. As recently reported by Suc et al [17], who performed a prospective randomized trial on temporary fibrin glue occlusion on the pancreatic stump, this technique did not significantly decrease the rate of intra-abdominal complications, notably pancreatic fistula, or their severity after pancreatic resection.…”

Pancreatic fistula following pancreatoduodenectomy. Evaluation of different surgical approaches in the management of pancreatic stump. Literature review

“…Di Carlo et al described low morbidity and mortality achieving duct occlusion with neoprene glue, but as side effects the loss of exocrine function as consequence of the pancreatic atrophy [51]. Various Authors proposed several glues and sealants (Prolamine, acrylic or neoprene glue, biological glues) to reach the same target with similar results [31,52].…”

Does fibrin glue sealant decrease the rate of pancreatic fistula after pancreaticoduodenectomy? Results of a prospective randomized trial

“…A number of nonrandomized series have suggested that application of fibrin glue sealant decreases the incidence of pancreatic fistula after pancreatic resection. [24][25][26][27] Furthermore, a prospective randomized trial including 56 patients has demonstrated that topical application of fibrin glue to the pancreatic stump after distal pancreatectomy significantly reduced pancreatic fistula rate. 28 In contrast, a prospective randomized trial of 96 patients undergoing both pancreaticoduodenectomy and distal pancreatectomy did not indicate a benefit regarding the application of fibrin glue.…”