Pancreatic Duct Diversity

Hać, Stanisław; Nałecz, A; Dobosz, Marek; Reszetow, Jacek; Dobrowolski, Sebastian; Friess, Helmut; Mihaljevic, André L.; Studniarek, Michał; Jaskiewicz, K; Śledziński, Zbigniew

doi:10.1097/mpa.0b013e31819081ba

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…26 Hac et al were one of the first to describe a pronounced diversity of the pancreatic duct system in humans. 27 The reported effects of inferior and posterior duct location might be due to the surgical techniques but also unknown variables including the tumour biology. Additional entities of anatomical importance such as proximity to neural plexuses should be taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

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Value of the surgical pancreatic duct anatomy and associated outcomes in pancreatic cancer

Harris,

Atanasov,

Neo

et al. 2024

ANZ Journal of Surgery

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IntroductionPancreatic cancer recurrence following surgery is a significant challenge, and personalized surgical care is crucial. Topographical variations in pancreatic duct anatomy are frequent but often underestimated. This study aimed to investigate the potential importance of these variations in outcomes and patient survival after Whipple's procedures.MethodsData were collected from 105 patients with confirmed pancreatic head neoplasms who underwent surgery between 2008 and 2020. Radiological measurements of pancreatic duct location were performed, and statistical analysis was carried out using IBM SPSS.ResultsInferior pancreatic duct topography was associated with an increased rate of metastatic spread and tumour recurrence. Additionally, inferior duct topography was associated with reduced overall and recurrence‐free survival. Posterior pancreatic duct topography was associated with decreased incidence of perineural sheet infiltration and improved overall survival.DiscussionThese findings suggest that topographical diversity of pancreatic duct location can impact outcomes in Whipple's procedures. Intraoperative review of pancreatic duct location could help surgeons define areas of risk or safety and deliver a personalized surgical approach for patients with beneficial or deleterious anatomical profiles. This study provides valuable information to improve surgical management by identifying high‐risk patients and delivering a personalized surgical approach with prognosis stratification.

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Section: Discussionmentioning

confidence: 99%

“…Hac et al . were one of the first to describe a pronounced diversity of the pancreatic duct system in humans 27 …”

Section: Discussionmentioning

confidence: 99%

Value of the surgical pancreatic duct anatomy and associated outcomes in pancreatic cancer

Harris,

Atanasov,

Neo

et al. 2024

ANZ Journal of Surgery

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“…The technique of pancreatic stump closure should consider the main duct stitching and second-degree duct management in the cut-line plane by precise suturing up. Several patients have large or aberrant second-degree ducts within the pancreatic body and tail [33]. These ducts might be of clinical importance in case of extended PD or pancreatic tail resection.…”

Section: Discussionmentioning

confidence: 99%

Surgical Morphology of the Pancreatic Isthmus

Hać¹,

Dobosz²,

Nałecz

et al. 2010

Pancreatology

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“…Thus, substitute strategy may provide beta-cell regeneration from the pancreas to correct insulin deficiency. Pancreatic duct refers to exocrine small lumen that delivers digestive enzymes and hormones [4]. Adult pancreatic ducts seem to be highly differentiated, but the capillary contacted ductal endothelial cell retains its proliferative capability [5].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Islet Hormones in Human Adult Pancreatic Ducts

Zhang

et al. 2015

Digestion

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Background/Aims: The source of insulin-secreting cells from adult duct system is attractive, but its clinical practice remains poorly understood. Here, we aimed at identifying the distribution of secreted hormone reactive cells in adult ducts. Methods: Consecutive pancreatic slices from nondiabetic subjects were subjected to immunohistochemistry and immunofluorescence to screen islet hormones (insulin; glucagon, Glu; somatostatin, Som; pancreatic polypeptide, PP) and exocrine biomarkers (cytokeratin 19, CK19; chromogranin A, CgA; amylase). All pancreatic sections were imaged using an optical or confocal microscope. Results: Immunostaining results showed that insulin was expressed in adult ducts, in which the cell count was more than other islet hormone immunoactive cells. CK19-positive cells are mainly distributed in the ducts, whereas CgA-labeled cells are localized in endocrine cells. The duct branches visibly exhibited cell populations that co-expressed islet hormones in exocrine cell populations. Conclusions: In this report, our findings demonstrate that adult ductal cells that produce insulin may contribute to beta-cell proliferation.

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Pancreatic Duct Diversity

Abstract: The pancreatic duct system in the body and the tail presents abnormal configuration not described in the past.

Cited by 4 publications

References 26 publications

Value of the surgical pancreatic duct anatomy and associated outcomes in pancreatic cancer

Value of the surgical pancreatic duct anatomy and associated outcomes in pancreatic cancer

Surgical Morphology of the Pancreatic Isthmus

Distribution of Islet Hormones in Human Adult Pancreatic Ducts

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