Pancreatic desmoid tumor: A rare case with radiologic–pathologic correlation

Dallaire, Frédéric; Dallaire, Étienne; Périgny, Martine

doi:10.1016/j.radcr.2018.04.025

Cited by 12 publications

(2 citation statements)

References 7 publications

(16 reference statements)

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“…It was diagnosed as a desmoid tumor by showing spindle cells and positive beta-catenin immunohistochemical staining. Therefore, a combination of radiologic images and pathology evaluation played an essential role in identifying the tumor [9] . Generally, the best treatment is decided based on location, the expansion of the tumor to neighboring organs, and risk to surrounding structures.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Shayesteh

Salimian

Fouladi

et al. 2020

Radiology Case Reports

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Desmoid tumors are rare, benign, and locally aggressive neoplasms that stem from connective tissue that have high rates of recurrence after surgery. Intra-abdominal desmoid-type fibromatosis can arise in 2 forms: sporadic or hereditary (associated with familial adenomatous polyposis and Gardner syndrome). The diagnosis of desmoid-type tumors is based on imaging modalities and histopathological examination. The primary treatment is resection surgery. We report a 64-year-old male with a distal pancreatic desmoid tumor. We focus on tumor management by the application of radiological modalities and pathological analysis.

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Section: Discussionmentioning

confidence: 99%

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Shayesteh

Salimian

Fouladi

et al. 2020

Radiology Case Reports

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“…Desmoid fibromatosis involving the pancreas is very rare, with to our knowledge only 31 cases previously reported in the English‐language literature 12‐26 . Due to their rarity and non‐specific imaging findings, pancreatic desmoid tumors are often initially suspected to be malignant tumors, and only identified as fibromatosis after resection.…”

Section: Introductionmentioning

confidence: 99%

A rare sporadic pancreatic desmoid fibromatosis diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration: Case report and literature review

Stone

Mallery

Stewart

et al. 2020

Diagnostic Cytopathology

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Intra‐abdominal desmoid fibromatosis (also known as desmoid tumor) is a rare benign but often locally aggressive infiltrative fibrous proliferation. Pancreatic desmoid fibromatosis is even rarer, with only 31 cases previously reported in the English‐language literature. These tumors present a distinct diagnostic challenge due to their rarity and non‐specific image findings and presentation, with most cases diagnosed as desmoid fibromatosis only after surgical resection. This report presents a rare case of pancreatic desmoid fibromatosis in a 72 year old man, who on a follow‐up CT for a previously diagnosed angiomyolipoma of the kidney was found to have a 4.0 cm pancreatic tail mass. This was sampled pre‐operatively by endoscopic ultrasound (EUS)‐guided fine‐needle aspiration (FNA). Examination of the cytology material showed a low‐grade spindle cell lesion. Immunohistochemistry (IHC) performed on FNA cell block showed the lesional cells to be positive for beta‐catenin, consistent with fibromatosis. Additional mutational analysis on cell block material revealed the characteristic CTNNB1 gene mutation (T41A), confirming the diagnosis. The mass was then surgically resected and again confirmed to be desmoid fibromatosis on histopathologic examination. On review of previously published cases of pancreatic desmoid fibromatosis, most were initially suspected to be some type of pancreatic neoplasm and were not biopsied prior to surgical resection. This case suggests a potential key role for fine‐needle aspiration cytology in the preoperative diagnosis of pancreatic and other intra‐abdominal desmoid tumors, particularly as evidence emerges that non‐surgical treatment may be a viable first option for some cases.

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Radiological features of pancreatic desmoid-type fibromatosis: a case series and systematic review

Tanishima,

Kurokawa,

Sone

et al. 2024

Abdom Radiol

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Purpose This retrospective study aimed to investigate the radiological features of pancreatic desmoid-type fibromatosis (PDF) and systematically review the previous publications and two new cases. Methods We searched PubMed, Cochrane Library, and Web of Science Core Collection and included 31 patients with pathologically proven PDFs with analyzable preoperative computed tomography (CT) and magnetic resonance imaging, including two patients from our institution and 29 patients from 28 publications. Two board-certified radiologists reviewed all images. Results The median age of the patients was 39 years, with a male dominance observed (male, 54.8% vs. female, 45.2%). Abdominal pain was the most frequent symptom, occurring in 58.1% of cases. Surgical resection was performed in all cases of PDFs, resulting in a recurrence rate of 8.3% (2/24). The tumors were most commonly located in the pancreatic tail (23/31, 74.2%). In terms of morphology, a “solid” shape was most prevalent (14/31, 45.2%), followed by a “solid and cystic” shape (9/31, 29.0%) and a “cystic” shape (8/31, 25.8%). Characteristic radiological features included heterogeneous enhancement of the solid portion of the tumors on CT scans (13/20, 65%), moderate-to-weak enhancement in the late phase on CT (16/17, 94.1%), and a presence of cystic components in the tumors (17/31, 54.8%). In 16.1% (5/31) of PDFs, the cystic component was pathologically confirmed to be a dilated pancreatic duct. Conclusion We summarized the clinical and imaging characteristics of PDF. Although the incidence may not be high, cystic components suggesting a dilated pancreatic duct within the tumor are unique imaging features in PDF.

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Pancreatic desmoid tumor: A rare case with radiologic–pathologic correlation

Cited by 12 publications

References 7 publications

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

A rare sporadic pancreatic desmoid fibromatosis diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration: Case report and literature review

Radiological features of pancreatic desmoid-type fibromatosis: a case series and systematic review

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