Pancreatic Carcinoma: Therapeutic Future Prospects

Abstract

In pancreatic cancer management progress has been made in the understanding of the disease on a molecular biological level and modalities for early diagnosis of pancreatic cancer have improved as well as the medical and surgical treatment strategies with curative, adjuvant and palliative aims. Realistic expectations for an earlier and more accurate diagnosis of pancreatic cancer – and thereby better treatment results – are constituted by the development of new blood tests and functional imaging. Adjuvants and neoadjuvants are presumed to be more effective and tolerable already in the near future, making the extended surgery more meaningful. On the same time, minimally invasive local treatments and laparoscopic resections are under development, eventually combined with localized growth factor treatment. One of the most important issue for improved clinical and oncological results is the centralization of complex resective procedures to few surgical centers, not due to the need of surgical skills but for an experienced team treatment approach during the operative and postoperative course. Finally, adjuvant treatment with pancreatic stem cells after curatively intended surgical resections is already on its way.

Pankreaskarzinom

“…Andrén-Sandberg et al [7] von der Karolinska Universität aus Stockholm begründen die Hoffnung auf bessere Ergebnisse in der Zukunft durch besserer Früherkennung, vielleicht sogar Screening von Risikogruppen, und differenziertere chirurgische und medikamentöse Strategien, basierend auf einem Literatur…”