Pancreatic Cancer Patients Who Smoke and Drink Are Diagnosed at Younger Ages

Abstract

Background & Aims-Cigarette smoking is an established risk factor for pancreatic cancer, but there is conflicting evidence regarding the effects of alcohol consumption. The effects of cigarettes and alcohol on age of sporadic pancreatic cancer diagnosis have not been examined; we evaluated the independent and synergistic effects of lifetime cigarette smoking and alcohol consumption on age at pancreatic cancer diagnosis in the United States.

85 Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age

“…For example, smoking has been demonstrated to lower the age of PC diagnosis approximately 15-20 years among patients with hereditary pancreatitis [44]. Likewise, smoking and alcohol have been associated with early onset PC in a dose-dependent manner [42,45]. In the current study, smoking had a statistically significant impact in lowering the mean age of PC diagnosis among patients who had a normal BMI-18 and became overweight or obese.…”

“…In contrast to genetic risk factors, modifiable PC risk factors such as smoking [39], alcohol use [40], obesity [14], and diabetes mellitus [41] increase an individual's relative risk of developing PC approximately 1 to 3-fold. Factors including smoking and alcohol use exhibit a variable effect often related to the magnitude of exposure and may substantially decrease the age of PC onset either alone [42] or in conjunction with other known PC risk factors [43]. For example, smoking has been demonstrated to lower the age of PC diagnosis approximately 15-20 years among patients with hereditary pancreatitis [44].…”

New Developments in Pancreatic Cancer

“…Recent epidemiologic research suggests that we should start looking more closely at heavy alcohol consumption. In our 2009 study, we found that pancreatic cancer patients who currently smoked cigarettes and drank alcohol were diagnosed at ages as much as 10.2 years younger than patients who abstained from alcohol and cigarettes [33]. A recent study from Italy re-examined the risks associated with these lifestyle habits in a sizeable case-control study, and reinforced the observation that current, but not former, cigarette smoking is associated with pancreatic cancer risk [34].…”

Stratégies de dépistage de l’adénocarcinome pancréatique chez les patients à haut risque : la place de l’écho-endoscopie

“…Dans l'Union européenne, un arrêt de la consommation de tabac réduirait de 15 % les nouveaux cas d'AP [52]. Le tabac majore également le risque de survenue à un âge plus jeune des AP sporadiques [53,54], des AP familiaux [55], et des AP compliquant les pancréatites héréditaires ou chroniques [56,57].…”