Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

Shields, Mario A.; Dangi-Garimella, Surabhi; Krantz, Seth B.; Bentrem, David J.; Munshi, Hidayatullah G.

doi:10.1074/jbc.m110.195628

Cited by 109 publications

(142 citation statements)

References 56 publications

(91 reference statements)

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“…Snail, a transcription factor, represses E-cadherin and thus contributes to the cancer progression (42). In addition, the interaction of Snail-MMP and cancer progression has been evident in pancreas, liver, and breast tissues (43)(44)(45). We demonstrated that FGF16 up-regulates Snail as well as reduces the E-cadherin expression and thus promotes invasion and metastasis of ovarian cancer cells.…”

Section: Discussionmentioning

confidence: 80%

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

Basu

Mukhopadhyay

Chatterjee

et al. 2014

Journal of Biological Chemistry

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Background:The mechanism of FGF16-mediated invasions in ovarian cancer cells was not reported. Results: Through the activation of FGFR-MAPK-pathway, FGF16 regulates SNAI1/CDH1/MMP2/-MMP9, promoting invasion of ovarian cancer cells. Wnt-signaling and PITX2 synergistically regulates FGF16 expression. Conclusion:The oncogenic potential of FGF16 in ovarian cancer was established. Significance: Growth factor/signaling pathways leading to increased proliferation/invasion of ovarian cancer were identified.

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Section: Discussionmentioning

confidence: 80%

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

Basu

Mukhopadhyay

Chatterjee

et al. 2014

Journal of Biological Chemistry

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“…Among these MMPs, Snail1 has been shown to up-regulate MMP-2 and MT1-MMP in hepatocellular and pancreatic ductal carcinomas (47,48). We observed up-regulation of MT1-MMP in MCF-7 cells expressing N455Q and N644Q LOXL2 (Fig.…”

Section: Mcf-7 Cells Stably Expressing N455q or N644q Loxl2 Exhibit Msupporting

confidence: 49%

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro

Moon

Finney

et al. 2013

Journal of Biological Chemistry

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Background: LOXL2 induces metastasis/invasion of breast cancer cells. Results: MCF-7 cells expressing nuclear associated LOXL2 have an invasive EMT phenotype. Conclusion: Nuclear associated catalytically competent LOXL2 contributes to stabilization of Snail1 transcription factor. Significance: This is the first study to directly compare the potencies of nuclear associated and secreted LOXL2s in breast cancer metastasis/invasion in vitro.

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“…Previous study showed that ERK1/2 are important for the pancreatic cancer cell invasion and cellular scattering in response to collagen I [20]. Furthermore, DDR2 has been implicated in signaling through ERK in regulation of breast cancer metastasis [13].…”

Section: Discussionmentioning

confidence: 99%

DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway

Poudel¹,

Lee²,

Kim³

2015

ABBS

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Metastatic melanoma is one of the most deadly and evasive cancers. Collagen I in the extracellular matrix promotes the migration and invasion of tumor cells through the production of matrix metalloproteinase (MMP) 2 and 9. Discoidin domain receptor (DDR) 2 is a collagen receptor that is implicated in several cancer types including breast and prostate cancers. However, the role of DDR2 in the migration and invasion of murine melanoma cells is less studied. In the present study, we investigated the effects and underlying mechanisms of DDR2 in migration and invasion of B16BL6 melanoma cells in response to collagen I. Results demonstrated that DDR2 is expressed and is phosphorylated by collagen I in the cells. Upon down-regulation of DDR2 using small-interfering RNA (siRNA) approach, both of the cell migratory and invasive phenotypes were significantly attenuated when compared with the control cells. This effect was mediated via suppression of MMP2/9 upon DDR2 inhibition. Furthermore, inhibition of DDR2 by specific siRNA markedly reduced the activation of extracellular regulated kinase (ERK) 1 and 2 and nuclear factor of kappa B (NF-κB) in the cells when compared with the control cells. Overall, these data demonstrated that DDR2 siRNA-mediated suppression of ERK1/2 and NF-κB could down-regulate the expressions of MMP2/ 9 in response to collagen I to reduce the migratory and invasive phenotypes of the cells.

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Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

Cited by 109 publications

References 56 publications

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro

DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway

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Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

Cited by 109 publications

References 56 publications

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

FGF16 Promotes Invasive Behavior of SKOV-3 Ovarian Cancer Cells through Activation of Mitogen-activated Protein Kinase (MAPK) Signaling Pathway

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro

DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-&kappa;B pathway

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DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway