Pancreatic cancer cells exchange ribosomes through tunneling nanotubes
Stanislava Martínková,
Denisa Jansová,
Jana Vorel
et al.
Abstract:SUMMARYPancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most lethal types of cancer. Tunneling nanotubes (TNTs) are thin membranous intercellular communications, which allow cells to exchange intracellular material and promote cell fitness. We show here that PDAC cells increase the formation of TNTs upon exposure to gemcitabine and that these TNTs contain ribosomal components. In the PANC-1 cell line and in PDAC explants obtained from patient biopsies, we observe polyadenylated RNA and assem… Show more
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