Pancreatic Cancer and Osteopontin

Weber, Cynthia E.; Erşahin, Çağatay; Kuo, Paul C.; Mi, Zhiyong

doi:10.1097/mpa.0000000000000639

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In addition, a recent study has reported that high glucose levels accelerated cell proliferation and increased the secretion of OPN in human pancreatic duct epithelial cells [ 124 ]. However, another study has reported that the presence of OPN in PC might have a protective effect independent of tumor stage [ 125 ], and a recent study has concluded that the relationship between OPN and PC remained unclear [ 126 ]. There are no reports which directly show the association of OPN with apoptosis in PC.…”

Section: The Association Of Opn With Apoptosis In Inflammatory Gi mentioning

confidence: 99%

Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?

Iida

Wagatsuma

Hirayama

et al. 2017

IJMS

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Osteopontin (OPN) is involved in a variety of biological processes, including bone remodeling, innate immunity, acute and chronic inflammation, and cancer. The expression of OPN occurs in various tissues and cells, including intestinal epithelial cells and immune cells such as macrophages, dendritic cells, and T lymphocytes. OPN plays an important role in the efficient development of T helper 1 immune responses and cell survival by inhibiting apoptosis. The association of OPN with apoptosis has been investigated. In this review, we described the role of OPN in inflammatory gastrointestinal and liver diseases, focusing on the association of OPN with apoptosis. OPN changes its association with apoptosis depending on the type of disease and the phase of disease activity, acting as a promoter or a suppressor of inflammation and inflammatory carcinogenesis. It is essential that the roles of OPN in those diseases are elucidated, and treatments based on its mechanism are developed.

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Section: The Association Of Opn With Apoptosis In Inflammatory Gi mentioning

confidence: 99%

Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?

Iida

Wagatsuma

Hirayama

et al. 2017

IJMS

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“…The next most common addiction after the use of psychoactive substances is smoking. Cigarette smoke has been shown to increase OPN expression, thereby contributing to the metastasis of lung cancer [58] as well as the development of pancreatic cancer [59][60][61], emphysema [62,63], pulmonary hypertension [64], bone tissue changes [65,66] and sinusitis in asthmatic patients [67]. Via the increase in OPN expression, it also affects macrophage activation [68] and osteogenic and osteoclastic signalling in the medial palatal suture [69].…”

Section: Opn and Use Of Psychoactive Substancesmentioning

confidence: 99%

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

Golub

Ordak

Nasierowski

et al. 2023

IJMS

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One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them.

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Endocrine regulation and metabolic mechanisms of osteopontin in the development and progression of osteosarcoma, metastasis and prognosis

Shao

Bi²

2023

Front. Endocrinol.

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Osteosarcoma is the most common type of malignant bone tumor, occurring in adolescents and patients over 60. It has a bimodal onset and a poor prognosis, and its development has not yet been fully explained. Osteopontin (OPN) is a high protein consisting of 314 amino acid residues with a negative charge and is involved in many biological activities. OPN is not only an essential part of the regulation of the nervous system and endocrine metabolism of skeletal cells. Still, it is also involved in several other important biological activities, such as the division, transformation, and proliferation of skeletal cells and their associated cells, such as bone tumor cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoblasts, and osteoclasts. Osteoblasts and osteocytes. Recent studies have shown a strong correlation between OPN and the development and progression of many skeletal diseases, such as osteosarcoma and rheumatoid arthritis. This review aims to understand the mechanisms and advances in the role of OPN as a factor in the development, progression, metastasis, and prognosis of osteosarcoma in an attempt to provide a comprehensive summary of the mechanisms by which OPN regulates osteosarcoma progression and in the hope of contributing to the advancement of osteosarcoma research and clinical treatment.

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Pancreatic Cancer and Osteopontin

Cited by 4 publications

References 5 publications

Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?

Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

Endocrine regulation and metabolic mechanisms of osteopontin in the development and progression of osteosarcoma, metastasis and prognosis

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