Pancreatic cancer and liver metastases: state of the art

Bellon, Eugen; Gebauer, Florian; Tachezy, Michael; Izbicki, Jakob R.; Bockhorn, Maximilian

doi:10.1007/s13304-016-0407-7

Cited by 32 publications

(22 citation statements)

References 29 publications

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“…Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States and the seventh worldwide 1 , 2 . Liver metastasis occurs in 70% of PC patients and the overall survival (OS) for PC patients with liver metastasis is only 11.1 months 3 . Therefore, identification of serum tumor markers of PC is urgently needed and may be helpful for convenient prognosis and treatment options.…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume predicts survival in pancreatic cancer patients with synchronous liver metastases

Jia

Wang

Zhang

et al. 2018

Sci Rep

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Most pancreatic cancer (PC) patients manifest multiple liver metastases at the time of diagnosis. Activated platelets play a key role in tumor growth and tumor metastases. Mean platelet volume (MPV) is a platelet index and is altered in patients with malignancies. This study aimed to evaluate whether MPV can effectively predict death in PC patients with synchronous liver metastases. The clinical data of 411 PC patients with synchronous liver metastases between January 1, 2006 and December 31, 2013 were retrospectively analyzed. Subjects were divided into two groups by MPV levels. Clinicopathological data were collected retrospectively and relationships between MPV levels and clinical parameters were evaluated. Survival analysis was performed. Increased MPV was not significantly correlated with tumor location, tumor size, and CA19.9. The Kaplan-Meier analysis showed that the overall survival of patients with MPV > 8.7 fL was significantly shorter than that of those with MPV ≤ 8.7 fL (log-rank p < 0.001). Multivariable Cox proportional hazards model identified MPV as an independent poor prognostic factor for overall survival. In conclusion, elevated MPV is associated with worse survival outcome in PC patients with synchronous liver metastases. Further studies are warranted.

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Section: Introductionmentioning

confidence: 99%

Mean platelet volume predicts survival in pancreatic cancer patients with synchronous liver metastases

Jia

Wang

Zhang

et al. 2018

Sci Rep

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“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer in Western countries, as it is mostly diagnosed at advanced stage with distant metastases [1–3]. For anatomic and organ specific reasons, the liver is the main target organ of PDAC metastasis and can be affected by hematogenic spread, but also by local invasion of cancer cells, growth along the nerve sheaths [4], as well as lymphatic spread.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes

et al. 2018

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Liver is the main target of pancreatic ductal adenocarcinoma (PDAC) metastasis. Here, a rat model was used for analysing gene expression modulations during liver colonization. ASML PDAC cells were injected to isogenic rats and re-isolated at various stages of liver colonization for RNA isolation or re-cultivation. Microarrays were used for analysing mRNA and miRNA profiles of expression. The results were partially confirmed by (q) RT-PCR and western blot. Selected genes were knocked down by siRNA transfection and the resulting cell behaviour was analysed. The ratio of up- and down regulated genes decreased from 20:1 (early stage) to 1.2:1 (terminal stage). Activation of cancer relevant gene categories varied between stages of liver colonization, with a nadir in the intermediate stage. The cells' environment triggered up to hundredfold changed expression for collagens, matrix metalloproteinases and chemokines. These modulations in mRNA expression were related to respective changes at miRNA levels. Gene expression knockdown of Mmp2 and Ccl20, which were highly modulated in vivo, was correlated with reduced proliferation and migration in vitro. Thus, target genes and temporal alterations in expression were identified, which can serve as basis for future therapeutic or diagnostic purposes.

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“…11 However, data on resection of PCLM remains sparse, and are mostly limited to case series or case reports. 12 Hence, it remains controversial whether patients with PCLM can benefit from resection. The main concerns are the postoperative mortality, morbidity, and most importantly, long-term survival.…”

Section: Resection Of Pclmmentioning

confidence: 99%

Surgical and local treatment of hepatic metastasis in pancreatic ductal adenocarcinoma: recent advances and future prospects

Jin

Dai

2020

Ther Adv Med Oncol

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with increasing incidence and mortality. More than half of PDAC patients develop metastases, with the liver being the most common site. Patients with pancreatic ductal adenocarcinoma with liver metastases (PCLM) have a very limited scope for surgery due to aggressive tumor behavior and poor prognosis. However, with the improvements in preoperative systemic therapy and perioperative outcomes, an increasing number of patients are being considered for surgical management. However, the best choice of surgical treatment and criteria for selecting suitable PCLM patients who may benefit from surgical treatment remains controversial. Palliative local treatments, such as ablation, locoregional chemotherapy, and brachytherapy, which are less invasive and have fewer contraindications and complications, are the preferred alternatives to surgery. The present study reviews the advances in the management of PCLM, with focus on resection and local therapies.

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Pancreatic cancer and liver metastases: state of the art

Cited by 32 publications

References 29 publications

Mean platelet volume predicts survival in pancreatic cancer patients with synchronous liver metastases

Mean platelet volume predicts survival in pancreatic cancer patients with synchronous liver metastases

Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes

Surgical and local treatment of hepatic metastasis in pancreatic ductal adenocarcinoma: recent advances and future prospects

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