Pancreatic Beta-cell Dysfunction in Type 2 Diabetes

Khin, Phyu Phyu; Lee, Jong Han; Lee, Youn-Jung

doi:10.1177/1721727x231154152

Cited by 16 publications

(9 citation statements)

References 137 publications

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“…The administration of streptozotocin in experimental rats was associated with sudden weight loss (Raj et al, 2022), extreme increase in blood glucose levels (Table 1) and morphological changes in the structure of the pancreas like destruction of insulin-producing beta cells, and degeneration and necrosis of pancreatic islets (Fig. 3 B) (Khin et al, 2023). The diabetic animals treated with HRS extract (Group 3) showed weight gain comparable to that of the normal control (Group 1) rats (Fig.…”

Section: Body Weightmentioning

confidence: 99%

Evaluation of antidiabetic potential of Hibiscus rosa sinensis on streptozotocin-induced diabetes on Wistar albino rats

Chauhan,

Rani

2024

JANS

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The chronic metabolic disease known as diabetes mellitus causes hyperglycemia in the body. Antioxidant and antidiabetic qualities are well-known benefits of Hibiscus rosa sinensis (HRS). In this work, diabetic Wistar albino rats were used to assess the antidiabetic properties of HRS flower extract. A total of 18 animals were taken and divided into three groups (n = 6) – (Group 1): Normal control group, (Group 2): Diabetic control group, (Group 3): Diabetic group treated with a 125 mg/kg dose of HRS flower extract. Group 2 animals showed a progressive decrease in body weight, while Group 1 animals showed a considerable gain in body weight. After overcoming the weight loss, Group 3 animals also showed an increase in body weight that was similar to Group 1. Group 2 animals had blood glucose levels higher than 400 mg/dL, but Group 1 animals had blood glucose levels below 200 mg/dL throughout the experiment. Group 3 animals first had glucose levels higher than 350 mg/dL and then lower than 200 mg/dL, comparable to Group 1 animals. Upon histological examination, the pancreatic islets of Group 2 animals showed vacuolation, necrosis, and degeneration. The animals in Group 3 displayed regenerated islets of Langerhans and enhanced pancreatic anatomy. The animals in Group 3 also returned to normal in terms of body weight and blood glucose levels, similar to those in Group 1. These findings show that Hibiscus rosa sinensis has potential as an alternative diabetic treatment; further research is needed to fully understand its modes of action and long-term effects.

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Section: Body Weightmentioning

confidence: 99%

Evaluation of antidiabetic potential of Hibiscus rosa sinensis on streptozotocin-induced diabetes on Wistar albino rats

Chauhan,

Rani

2024

JANS

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“…In line with the current fndings, HWE of MX, numerous mushroom extracts including Agaricus bisporus, Cyclocybe aegerita, Cyclocybe cylindracea, and Tremella fuciformis have been investigated for the treatment or prophylaxis of type-2 diabetes, which develops when insulin production is unbalanced as a result of the dysfunction of insulin-secreting beta cells in the pancreas [134,135]. Mushrooms assist patients in avoiding excessive blood sugar levels since they are the food with the least quantity of digestible carbohydrates [136].…”

Section: Gc-ms Analysis Of Hot Water Extract Ofmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes,

Sbhatu

2023

International Journal of Analytical Chemistry

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Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites’ biological and pharmacological effects can be aided by identifying them. The purpose of this work was to profile the mycochemical components of the extracts of Auricularia auricula judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, and Trametes versicolor to comprehend their biological and pharmacological capabilities. Mushroom samples were collected from Kenya’s Arabuko–Sokoke and Kakamega National Reserved Forests and identified using morphological and molecular techniques. Chloroform, 70% ethanol, and hot water solvents were used to extract the mycochemical components. Gas chromatography mass spectrometry (GC-MS) was used to analyze the chloroform, 70% ethanol, and hot water extracts of all the species examined. A total of 51 compounds were isolated from all extracts and classified as carboxylic acids, esters, phenols, fatty acids, alcohol, epoxides, aldehydes, fatty aldehydes, isoprenoid lipids, and steroids. Tetracosamethyl-cyclododecasiloxane (18.90%), oleic acid (72.90%), phenol, 2, 6-bis (1, 1-dimethylethyl)-4-methyl-, and methylcarbamate (26.56%) were all found in high concentrations in A. auricular judae, M. xanthopus, T. umkowaani, T. elegans, and T. versicolor, respectively. Fatty acids make up the majority of the compounds isolated from the T. elegans chloroform extract and the T. umkowaani 70% ethanol extract, respectively. Particularly, these fatty acids play crucial roles in the anti-inflammatory, hypocholesterolemic, anticancer, and antibiofilm formation activities. These bioactive elements indicate that the extracts of five wild mushrooms may be reliable sources of secondary metabolites for therapeutic development. Therefore, additional research is required to comprehend the usefulness of these chemicals in many functional areas and to improve the present understanding of macrofungi.

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“…2 , 11 , 13 Type 2 diabetes (T2D) is marked by insulin resistance, where the body’s cells do not respond effectively to insulin, and insufficient insulin production. 10 , 11 , 14 , 15 The complications of diabetes are diverse and affect various organ systems, including the cardiovascular system, kidneys, eyes, and oral cavity. 1 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Exploring Interleukin-10 Levels in Diabetes Patients with and without Oral Diseases: A Systematic Review

Novianti,

Nur’aeny

2024

JIR

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Aim Interleukin-10 (IL-10) is a cytokine that plays an important role in the progression of diabetes mellitus (DM). Oral diseases were more common in diabetics than in non-diabetics. The aim of this review is to identify IL-10 levels in diabetic patients with and without oral diseases. Methods A systematic review was conducted based on the PRISMA guidelines. Three databases (PubMed, Cochrane Library, and Science Direct) were used to search for articles up to November 2023 for studies on the measurement of IL-10 in diabetics with and without oral disease. The criteria were limited to human studies and full-text in English only. The outcome was the value of IL-10. The study was quality-graded using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS). Results There were eleven articles that met the eligibility criteria for analysis. Four articles discovered higher IL-10 levels, while seven articles discovered lower IL-10 levels in diabetes patients with oral diseases compared with each control group. Conclusion Most studies showed lower IL-10 levels in diabetic patients with oral diseases compared with the control group.

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Pancreatic Beta-cell Dysfunction in Type 2 Diabetes

Cited by 16 publications

References 137 publications

Evaluation of antidiabetic potential of Hibiscus rosa sinensis on streptozotocin-induced diabetes on Wistar albino rats

Evaluation of antidiabetic potential of Hibiscus rosa sinensis on streptozotocin-induced diabetes on Wistar albino rats

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Exploring Interleukin-10 Levels in Diabetes Patients with and without Oral Diseases: A Systematic Review

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