Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes

Fakhfakh, R.; Haddouk, Samy; Hamida, Y B Hadj; Kamoun, Thouraya; Ayed, M. Ben; Hachicha, M.; Masmoudi, Hatem

doi:10.1016/j.patbio.2007.09.019

Cited by 8 publications

(8 citation statements)

References 14 publications

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“…This shows the importance of using multiple antibodies testing before ruling out immune mediated type 1 diabetes mellitus. Our finding is similar to a figure of 90.7% that has been reported from Tunisia [11] cases. It is lower than the frequency of 60-80% reported in Caucasian population [26].…”

Section: Discussionsupporting

confidence: 93%

“…Using multiple antibodies testing however might be expensive and if at all one is to use two antibodies rather than three, we have found that combining 1AA with GADA is sensitive than combining it with ZNT8A. This is similar to a report from Tunisia [11]. During SEARCH study [13] 15.1% of type 1 diabetes patients were autoantibody negative.…”

Section: Discussionsupporting

confidence: 86%

“…Insulin auto antibodies were detected in 36% of our patients and this falls in the lower limit of figures of 40-70% reported in literature [5][6][7][8]14,15]. It is similar to data from Saudi Arabia [16] and Japan [17] but lower than figures of 69% [18] and 50% reported from UK and Tunisia [11,18] respectively. This wide range in the frequency of IAA may be due to heterogeneity of IAA repertoire recognizing different epitopes of Insulin [19].…”

Section: Discussionsupporting

confidence: 82%

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Pancreatic Autoantibodies in Sudanese Children with Newly Diagnosed Type 1 Diabetes Mellitus

Rabab¹,

Urwa²,

Abdullah³

2019

Int J Diabetes Clin Res

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Background: Immunepositive type one diabetes mellitus is the commonest cause of diabetes in children worldwide. Seronegative cases are said to be more common among black Africans. In a previous study in Sudan 46% of cases were found to have positive GAD antibodies. Objectives of the study: The aim of this study was to find out the prevalence of pancreatic autoantibodies among multiethnic group of newly diagnosed Sudanese children by testing for multiple antibodies and to see how common are seronegative cases as reported in black Africans. Subjects and methods: Eighty newly diagnosed children aged (1-18 years) of multiethnic groups with clinical diagnosis of type 1 diabetes mellitus were tested for 3 islet cell antibodies Glutamic Acid Decarboxylose (GADA), insulin autoantibodies (IAA) and Zinc Transporter (ZNT8A) using ELISA (ZNT8M GADA) and Radioimmunoassay (RIA) for IAA. Demographic and clinical data were obtained from the records-clinical presentations of the….seronegative cases was compared with the seropositive cases. Results: A positive result for one or more antibodies was found in 73 (91.2%) and negative in 7 (8.8%) of the cases-No ethnic variation was demonstrated. There was no difference in the clinical presentation of the two group. IAA was positive in 29 (36.3%), GADA in 62 (77.5%) and ZNT8A in 13 (16.3%). On testing for two antibodies, the best yield was on combining GADA and IAA 61 (76.3%). Conclusion: Unlike the previous study from Sudan most (91.2%) of Sudanese children with Type 1 diabetes have got one or more pancreatic antibodies at onset. However 8.2% are seronegative. Further studies to find the causes in this seronegative group is needed.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 82%

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Pancreatic Autoantibodies in Sudanese Children with Newly Diagnosed Type 1 Diabetes Mellitus

Rabab¹,

Urwa²,

Abdullah³

2019

Int J Diabetes Clin Res

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“…37,39 Only one paper looked at the frequency of all four autoantibodies in 86 newly diagnosed type 1 diabetic children from Tunisia. 31 The authors found that 78 (90.7%) children were positive for one or more autoantibody. Only three papers were identified that reported the screening of black South Africans for the presence of disease-associated autoantibodies.…”

Section: Introductionmentioning

confidence: 98%

“…24 In Africa, there seem to be conflicting reports regarding the gender ratios of black patients with type 1 diabetes (see Table II As seen in Table III, there is wide variation in the frequency of ICAs within Africa. [29][30][31][32][33][34][35][36] The observed frequencies are lower than those reported in Caucasian type 1 diabetic populations. 37 Less than a third of the publications considered the presence of two or more autoantibodies.…”

Section: Introductionmentioning

confidence: 99%

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Padoa

2011

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Type 1 diabetes is a serious, debilitating disease, with life-threatening complications, and the financial burden associated with the management of this disease is enormous. Early diagnosis and intervention can improve morbidity and mortality. Unfortunately, in Africa, type 1 diabetes is poorly characterised, and there is sparse information regarding the aetiology and epidemiology of this disease. However, there is some evidence of a later age of onset in African type 1 diabetic patients, compared to European diabetics, and it is thought that the prevalence of type 1 diabetes is lower in African populations than in the Western world.

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Clinical, biochemical, and immunological characteristics of newly diagnosed nonobese diabetic patients aged 18–45 years in China

Shi

Sun

Feng

et al. 2012

Journal of Diabetes and its Complications

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Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes

Cited by 8 publications

References 14 publications

Pancreatic Autoantibodies in Sudanese Children with Newly Diagnosed Type 1 Diabetes Mellitus

Pancreatic Autoantibodies in Sudanese Children with Newly Diagnosed Type 1 Diabetes Mellitus

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Clinical, biochemical, and immunological characteristics of newly diagnosed nonobese diabetic patients aged 18–45 years in China

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