Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative

Effective synthesis of some novel 7,8-substituted coumarins through Heck reaction and Sonogashira’s coupling reactions

“…Thus, in the Heck coupling reaction,( Scheme-1) the expected product 20 was not obtained and an unreported compound 21 was resulted as a major product along with compound 22 as a minor product also de-iodinated 15 , 18 .The products are widely used for the treatment of disease like cancer [16][17][18][19][20] . Sonogashira coupling reaction (Scheme-2) of 8-iodo umbelliferone 17 with propargyl alcohol 23 using triethylamine, freshly prepared tetrakis(triphenylphosphine)palladium catalyst and copper (I) iodide in dry THF was carried out.…”

Green Antioxidants: Synthesis and Scavenging Activity of Coumarin-Thiadiazoles as Potential Antioxidants Complemented by Molecular Modeling Studies

“…8,9 Free radicals are highly reactive atoms or molecules that have unpaired electron. 10,11 4-hydroxycoumarin and thiadiazoles represent promising scaffolds in the medicinal chemistry field. The aim of this work was to find new chemical structures with antioxidant activity, we have designed new scaffolds in which the thiadiazoles fragment is partially incorporated in the 4-hydroxycoumarin moiety.…”

Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors

“…The presence of coumarin architecture in naturally occurring phytoconstituents with anticancer 15,16 , anti-HIV 17 , antituberculosis 18 , anti-influenza 19 , antialzheimer 20,21 , anti-inflammatory 22 , antiviral 23 , antimicrobial 13 and xanthine oxidase inhibitory activities [24][25][26] makes it a privileged structure. Among the diverse array of biological activities possessed by coumarins, we are particularly interested towards their xanthine oxidase inhibitory potential which has also been extensively explored [24][25][26] .…”