Pancreatic adenocarcinoma with osseous metaplasia in a ferret

Kornegay, R W; Morris, JB; Cho, D.; Lozano-Alarcon, Fernando

doi:10.1016/s0021-9975(08)80067-9

Cited by 12 publications

(3 citation statements)

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“…In fact, only one description of bone metaplasia is available for this group, associated, however, with severe skin lesions in a dolphin found entangled in fisher nets ( St. Leger et al, 2018 ). Bone metaplasia in mammals is mainly caused by tumors ( Kornegay et al, 1991 ; Sant'Ana et al, 2002 ; Bangari and Stevenson 2007 ; Kannegieter et al, 2010 ; Ramirez et al, 2010 ; Ohfuji 2012 ), followed by metabolic and eating disorders ( Han and Gardiner, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

Jerdy¹,

Werneck²,

Barbosa³

et al. 2022

International Journal for Parasitology: Parasites and Wildlife

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A female Cuvier's Beaked Whale ( Ziphius cavirostris ) specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were obtained, fixed in 10% neutral buffered formalin and histopathologically analyzed. A severe and generalized hypodermis infection by Phyllobothrium delphini (Phyllobothriidae) was observed, resulting in granulomatous panniculitis. Severe renal and arterial lesions were also noted, including a severe bone metaplasia in the aorta artery, associated with a massive infection by Crassicauda sp, (Tetrameridae). A significant thoracic hemorrhage due to thoracic aorta artery rupture was noted, also likely due to this infection, resulting in a fatal injury. This study contributes towards knowledge on histopathologic changes in the scarcely studied Cuvier's Beaked Whale, is the first to associate a Crassicauda sp. infection in this whale species in the Brazilian region and also the first to indicate a resulting osseous metaplasia due to this parasitism and granulomatous dermatitis associated with Phyllobothrium delphini . Furthermore, this is also, to the best of our knowledge, the first report of Phyllobothrium delphini cysts in a Ziphius cavirostris specimen to date.

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Section: Discussionmentioning

confidence: 99%

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

Jerdy¹,

Werneck²,

Barbosa³

et al. 2022

International Journal for Parasitology: Parasites and Wildlife

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“…In veterinary species, bone is commonly identified in fibromas derived from the periodontal ligament, maxillary fibromas of young horses, canine mixed mammary tumors, and in some chondrosarcomas . Less frequently, bone has been described within canine mixed thyroid tumors, mixed apocrine sweat gland tumors, gastrointestinal adenocarcinomas, oral malignant melanomas, and a pancreatic exocrine adenocarcinoma in a ferret . The current case represents the first report of bone formation within an insulinoma (islet cell carcinoma) in animals or people.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Less frequently, bone has been described within canine mixed thyroid tumors, mixed apocrine sweat gland tumors, gastrointestinal adenocarcinomas, oral malignant melanomas, and a pancreatic exocrine adenocarcinoma in a ferret. [17][18][19][20][21][22] The current case represents the first report of bone formation within an insulinoma (islet cell carcinoma) in animals or people.…”

Section: Discussionmentioning

confidence: 99%

Osseous metaplasia within a canine insulinoma

Pieczarka

Russell

Santangelo

et al. 2014

Veterinary Clinical Pathol

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An 11-year-old male castrated mixed-breed dog was presented for exercise intolerance, tetraparesis, and persistent hypoglycemia. Abdominal ultrasound examination revealed 2 nodules within the right limb of the pancreas. Cytology from one nodule was consistent with a carcinoma of neuroendocrine origin, with a primary differential diagnosis of insulinoma. Histologic evaluation and immunohistochemistry for synaptophysin and insulin confirmed the diagnosis of insulinoma. Additionally, there was a solitary nodule of mineralized compact bone composing approximately 60% of the mass. To the authors' knowledge, this is the first report of osseous metaplasia within an insulinoma (islet cell carcinoma). Case PresentationAn 11-year-old male castrated mixed-breed dog was presented to the Ohio State University Veterinary Medical Center (OSUVMC) for evaluation of exercise intolerance and tetraparesis for several weeks' duration, as well as persistent hypoglycemia. Serum chemistry performed at OSUVMC showed sustained marked hypoglycemia (36 mg/dL; reference interval [RI] 77-126 mg/dL), mild hypokalemia (3.92 mEq/L; RI 4.2-5.4 mEq/L), and mildly elevated total serum ALP activity (148 IU/L; RI 15-120 IU/L]) with significantly increased corticosteroid-induced ALP isoenzyme activity (138 IU/L; RI 0-6 IU/L). An abdominal ultrasound examination identified 2 hypoechoic nodular structures measuring 2.9 9 1.9 cm (cranial nodule) and 3.3 9 1.4 cm (caudal nodule) in the right limb of the pancreas. The echogenicity of these nodules was heterogenous with focal hyperechoic shadowing regions. A fine-needle aspirate of one pancreatic nodule revealed many variably sized clusters of large, round to polygonal shaped cells within a background of blood and numerous bare nuclei (Figure 1). Neoplastic cells displayed mild-to-moderate anisocytosis and anisokaryosis. Nuclei were round to oval, centrally placed, and had a fine chromatin structure with 1-3 prominent round to ovoid nucleoli. These cells had moderate amounts of basophilic cytoplasm that frequently contained multiple small punctate vacuoles. Occasional cell clusters contained distinct intercellular junctions and/or piling of cells, as well as multiple ruptured cells.Rare binucleated cells, nuclear molding, and mitotic figures were observed. These findings were compatible with a carcinoma of neuroendocrine origin. The primary differential diagnosis was an insulinoma.Thoracic radiographs were acquired prior to surgery and revealed no evidence of metastasis. A partial pancreatectomy was performed of the right limb along with surgical excision of 2 regional lymph nodes, and Figure 1. Fine-needle aspirate of a pancreatic mass in a dog. Note a cluster of malignant epithelial cells with moderate amounts of pale basophilic cytoplasm with varying numbers of small punctuate vacuoles, and round nuclei with a fine chromatin structure and prominent nucleoli. There are also a few bare nuclei and ruptured cells, suggestive of neuroendocrine origin. Modified Wright-Giemsa. Bar = 10 lm.

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