Pancreatic adenocarcinoma: the impact of preneoplastic lesion pattern on survival

Flattet, Yves; Yamaguchi, Takeshi; Andrejevic‐Blant, Snezana; Halkic, Nermin

doi:10.5582/bst.2015.01163

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Other series also suggest that pancreatic ductal adenocarcinomas derived from IPMN and those concomitant with IPMN are significantly smaller, less invasive, and less extensive than ordinary pancreatic ductal adenocarcinoma [ 25 , 26 ]. Two series undergoing resection for IPMN-associated carcinoma indicated that prognosis of IPMN-associated carcinoma depends on histologic tumor subtype and grading [ 27 , 28 ]. A series of 35 patients having pancreatic resection for cancer aimed to assess the impact of the preneoplastic lesion pattern on survival.…”

Section: Discussionmentioning

confidence: 99%

“…The authors reported that PanIN-related carcinomas displayed more aggressive features than IPMN-related carcinomas. Survival was significantly lower in cancers arising from PanIN preneoplastic lesions [ 27 ]. In a large series of 424 patients of IPMN-associated carcinomas, IPMN-ductal adenocarcinomas were diagnosed at more advanced tumor stages, more frequently involved lymph nodes, poorer differentiation and positive-margin resection and were associated with shorter median overall survival than IPMN-colloid carcinoma (26.7 months vs. 91.3 months) [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Preneoplastic Lesions in Surgical Specimens Do Not Worsen the Prognosis of Patients Who Underwent Surgery for Pancreatic Adenocarcinoma: Post-Hoc Analysis of the PRODIGE 24-CCTG PA 6 Trial

Legrand

Salleron²,

Conroy³

et al. 2022

Cancers

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Objective: The prognosis of pancreatic cancer after curative surgery is burdened by frequent recurrence. The aim of this study was to evaluate the impact of dysplasia in the surgical specimen on disease-free survival (DFS). Methods: A post-hoc analysis of the phase III PRODIGE 24-CCTG PA 6 trial was performed. From April 2012 to October 2016, 493 patients were included in the primary study. Assessment for dysplasia in the surgical specimens was secondarily performed. Dysplasia was defined based on presence and grade of three most common pre-malignant lesions (intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN) and pancreatic intraepithelial neoplasia (PanIN). The primary endpoint was DFS validated through multivariate analysis. Results: Two hundred twenty-six patients (45.9%) had a preneoplastic lesion. PanIN lesions were found in 193 patients (39.2%), including 100 high-grade lesions (20.6%); 43 patients had IPMN lesions (8.7%), including high-grade lesions in 32 (6.5%). Three MCN were described (0.6%). In bivariate analysis, the presence of dysplasia was not associated with poorer DFS (HR = 0.82, 95% CI [0.66; 1.03]). In multivariate analysis, risk factors for poorer DFS were poorly differentiated/undifferentiated tumor, N1 status, R1 surgical margins and perineural invasion. Conclusions: The presence of dysplasia in the surgical specimen after pancreatic cancer surgery does not worsen DFS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preneoplastic Lesions in Surgical Specimens Do Not Worsen the Prognosis of Patients Who Underwent Surgery for Pancreatic Adenocarcinoma: Post-Hoc Analysis of the PRODIGE 24-CCTG PA 6 Trial

Legrand

Salleron²,

Conroy³

et al. 2022

Cancers

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“…Pancreatic adenocarcinoma (PAAD) is a common type of PC, accounting for ~85% of all PC cases (7). The survival rate of PAAD is very low and the 5-year survival rate was 5% in 2015 (8). A few prognostic indicators are now available for PC, such as C-reactive protein/albumin ratio and neutrophil/lymphocytes ratio (9,10).…”

Section: Introductionmentioning

confidence: 99%

Prognostic prediction of a 12‑methylation gene‑based risk score system on pancreatic adenocarcinoma

2020

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Pancreatic adenocarcinoma (PAAD) accounts for ~85% of all pancreatic cancer cases and is associated with a less favorable prognosis. Aberrant DNA methylation may influence the progression of PAAD by inducing abnormal gene expression. Methylation data of PAAD samples with prognosis information were obtained from The Cancer Genome Atlas (training set) and European Bioinformatics Institute Array Express databases (validation sets). Using the limma package, the differentially methylated genes in the training dataset were screened. Combined with the Weighted Gene Co-expression Network Analysis package, the co-methylated genes in key modules were identified. Then, a cor.test function in R software was applied to explore the functions of key the methylated genes. Correlation analyses of the expression levels and methylation levels of key methylated genes were performed, followed by identification of methylated genes associated with prognosis using Univariate Cox regression analysis. The optimal combination of prognosis related methylated genes was determined using a Cox-Proportional Hazards (Cox-PH) model. Subsequently, the risk score prognostic prediction system was constructed by combining the Cox-PH prognosis coefficients of the selected optimized genes. Based on the constructed risk score system, samples in all datasets were divided into high and low risk samples and the survival status was compared using survival curves. Furthermore, the correlation between independent prognostic factors and the risk score system was determined using the survival package. A total of 50 genes associated with prognosis of PAAD and a 12-gene optimal combination were obtained, including: CCAAT/enhancer binding protein α, histone cluster 1 H4E, STAM binding protein-like 1, phospholipase D3, centrosomal protein 55, ssDNA binding protein 4, glutamate AMPA receptor subunit 1, switch-associated protein 70, adenylate-cyclase activating polypeptide 1 receptor 1, yippee-like 3, homeobox C4 and insulin-like growth factor binding protein 1. Subsequently, a risk score prognostic prediction system of these 12 genes was constructed and validated. In addition, pathological N category, radiotherapy and risk status were identified as independent prognostic factors. Overall, the risk score prognostic prediction system constructed in the present study may be effective for predicting the prognosis of patients with PAAD.

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Pancreatic Carcinogenesis

Taucher¹,

Haybaeck²

2017

Mechanisms of Molecular Carcinogenesis – Volume 2

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Pancreatic adenocarcinoma: the impact of preneoplastic lesion pattern on survival

Cited by 6 publications

References 16 publications

Preneoplastic Lesions in Surgical Specimens Do Not Worsen the Prognosis of Patients Who Underwent Surgery for Pancreatic Adenocarcinoma: Post-Hoc Analysis of the PRODIGE 24-CCTG PA 6 Trial

Preneoplastic Lesions in Surgical Specimens Do Not Worsen the Prognosis of Patients Who Underwent Surgery for Pancreatic Adenocarcinoma: Post-Hoc Analysis of the PRODIGE 24-CCTG PA 6 Trial

Prognostic prediction of a 12‑methylation gene‑based risk score system on pancreatic adenocarcinoma

Pancreatic Carcinogenesis

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