Pancreatic Adenocarcinoma

Abstract

This study demonstrates that, based on high numbers of ELN, PLN is superior to LNR in predicting survival and allows to distinguish several N-categories that improve prognostic accuracy in LN-positive resectable pancreatic adenocarcinoma.

Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study

“…The study demonstrated the importance of obtaining a high number of examined lymph nodes (ELN) (median 24, range [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32], and the superiority of PLN compared to LNR in predicting survival. In the N-positive group, median survival of patients with 1 PLN was comparable to the survival of N0 patients 23 . In this present analysis, demographic factors, tumour characteristics, stage, operative characteristics and postoperative therapy and their impact on long survival were studied.…”

“…In the group of patients without the above-mentioned risk factors, 5-year survival was reached by more than 54%; however, the overall 5-year survival rate (OS) was not reported 22 . Another prospective study (811 pts/12 years) by Strobel (2015), evaluated lymph nodes and the stratification of different prognoses according to the number of positive lymph nodes (PLN). The study demonstrated the importance of obtaining a high number of examined lymph nodes (ELN) (median 24, range [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32], and the superiority of PLN compared to LNR in predicting survival.…”

State of the art and future directions of pancreatic ductal adenocarcinoma therapy

“…About 20%-30% of patients with resected PDAC, even those who received adjuvant chemotherapy, develop early relapse and die within the year following surgery. This lack of benefit from the surgery plus adjuvant chemotherapy sequence strategy is mainly observed in patients with R1 or N+ tumors (J. R. Delpero et al, 2014;Strobel et al, 2015). This observation has led to the exploration of neoadjuvant therapy (i.e.…”

Nutrients and the Pancreas: An Epigenetic Perspective

“…Pancreatic ductal adenocarcinoma is most commonly found in the exocrine portion of the pancreas [15] and is the most lethal common cancer because of its resistance to therapy and its propensity to metastasize early in the disease progression [16,17]. Pancreatic cancer more frequently affects elderly men than any other population [16,17,18,19]. According the American Cancer Society, the five-year survival rate from 2003 to 2009 for pancreatic cancer was six percent [20].…”

“…According the American Cancer Society, the five-year survival rate from 2003 to 2009 for pancreatic cancer was six percent [20]. However, of those diagnosed, an overwhelming percentage (85%–95%) of the cancers of the pancreas are ductal adenocarcinomas, therefore we will use pancreatic cancer and pancreatic ductal adenocarcinoma interchangeably [15,17]. …”