1997
DOI: 10.1172/jci119714
|View full text |Cite
|
Sign up to set email alerts
|

Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis.

Abstract: The aim of this study was to determine whether tumor necrosis factor-␣ (TNF ␣ )

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

14
301
3
3

Year Published

2000
2000
2021
2021

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 351 publications
(321 citation statements)
references
References 45 publications
(58 reference statements)
14
301
3
3
Order By: Relevance
“…This becomes evident when the effects of the inhibitor used in our study are compared in two different organs and models: whereas TNF-␣-and FAS-induced liver apoptosis was significantly decreased (Roquet et al, 1996), the same inhibitor was ineffective in modulating acinar cell apoptosis in acute pancreatitis. Although TNF-␣ is known to be involved in acinar cell apoptosis in acute pancreatitis (Gukovskaya et al, 1997), it did not seem to be the only mechanism involved in the regulation of apoptotic acinar cell death in the current study, because TNF-␣ expression in ICE-I-treated animals was reduced despite the same incidence of apoptosis. Other factors, such as expression and up-regulation of the FAS/FAS ligand system, may outweigh TNF-␣ in this respect (Iovanna, 1996;Roquet et al, 1996).…”
Section: Il-1␤-converting Enzyme In Acute Pancreatitiscontrasting
confidence: 59%
See 1 more Smart Citation
“…This becomes evident when the effects of the inhibitor used in our study are compared in two different organs and models: whereas TNF-␣-and FAS-induced liver apoptosis was significantly decreased (Roquet et al, 1996), the same inhibitor was ineffective in modulating acinar cell apoptosis in acute pancreatitis. Although TNF-␣ is known to be involved in acinar cell apoptosis in acute pancreatitis (Gukovskaya et al, 1997), it did not seem to be the only mechanism involved in the regulation of apoptotic acinar cell death in the current study, because TNF-␣ expression in ICE-I-treated animals was reduced despite the same incidence of apoptosis. Other factors, such as expression and up-regulation of the FAS/FAS ligand system, may outweigh TNF-␣ in this respect (Iovanna, 1996;Roquet et al, 1996).…”
Section: Il-1␤-converting Enzyme In Acute Pancreatitiscontrasting
confidence: 59%
“…The expression of active IL-1␤ and TNF-␣ protein in the pancreata of healthy control animals without any evidence of intrapancreatic leukocyte infiltration and in the absence of detectable mRNA levels strongly suggests that both cytokines are synthesized and stored within the acinar cells themselves and play a physiologic role in the process of tissue homeostasis. So far, this has only been demonstrated for TNF-␣ (Gukovskaya et al, 1997). During the early stages of acute pancreatitis, considerable amounts of intrapancreatic IL-1␤ and TNF-␣ seem to be released by acinar cells undergoing necrosis, which correlates well with the difference in the extent of necrosis found between the treated group and untreated group.…”
Section: Il-1␤-converting Enzyme In Acute Pancreatitismentioning
confidence: 87%
“…Approaches that aim to decrease the systemic inflammatory process and oxidative stress have gained momentum, but a consensus has not yet been formed for a drug that administers effective treatment 6,7,18 .…”
Section: Discussionmentioning
confidence: 99%
“…49,50 To elucidate whether bilirubin cytotoxicity is due to induction of cellular necrosis, release of LDH from bilirubin-treated HCT15 cells was assessed at 24 and 48 hr. For these studies, HCT15 monolayers were incubated in the presence of bilirubin (50 M) or DMSO vehicle, and the concentration of FIGURE 3 -LDH release from colon cancer cells treated with bilirubin.…”
Section: Mechanism Of Bilirubin-induced Cell Deathmentioning
confidence: 99%