Pancreas transplantation using compatible but non‐identical ABO blood group donors

Nagaraju, Santosh; Mangus, Richard S.; Powelson, John A.; Fridell, Jonathan A.

doi:10.1111/ctr.13284

Cited by 1 publication

(2 citation statements)

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“…Arterial reconstruction was done using the donor iliac artery Y‐graft and portal vein anastomosed end‐to‐side to the respective recipient iliac artery and iliac vein or vena cava, respectively. The exocrine secretions of the PTA were drained using the urinary bladder until 1997 at one center and 2004 at two centers and later drained to the distal ileum or proximal jejunum 19–21 . Enteric conversion of bladder drainage was not reported to UNOS.…”

Section: Methodsmentioning

confidence: 99%

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Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study

Kaur,

Mujtahedi,

Fridell

et al. 2023

Clinical Transplantation

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Pancreas transplantation alone (PTA) is a β cell replacement option for selected patients with type 1 diabetes mellitus; concerns have been raised regarding deterioration in kidney function (KF) after PTA. This retrospective multicenter study assessed actual impact of transplantation and immunosuppression on KF in PTA recipients at three Transplant Centers. The primary composite endpoint 10 years after PTA was >50% eGFR decline, eGFR < 30 mL/min/1.73 m2, and/or receiving a kidney transplant (KT). Overall, 822 PTA recipients met eligibility. Median baseline and 10‐year eGFR (mL/min/1.73 m2) were 76.3 (58.1–100.8) and 51.3 (35.3–65.9), respectively. Primary composite endpoint occurred in 98 patients (53.5%) with 45 experiencing a >50% decrease in eGFR by 10 years post‐transplant, 38 eGFR < 30 mL/min/1.73 m2 and 49 requiring KT. KF declined most significantly within 6 months post‐PTA, more often in females and patients with better preserved GFR up to 5 years with 11.6% kidney failure at 10 years. Patient survival and death‐censored graft survival were both 68% at 10 years with overall graft thrombosis rate 8%. KF declined initially after PTA but stabilized with further slow progression. In conclusion, prospective intervention studies are needed to test renal sparing interventions while gathering more granular data.

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Section: Methodsmentioning

confidence: 99%

“…The exocrine secretions of the PTA were drained using the urinary bladder until 1997 at one center and 2004 at two centers and later drained to the distal ileum or proximal jejunum. [19][20][21] Enteric conversion of bladder drainage was not reported to UNOS. S11)…”

Section: Surgical Techniquementioning

confidence: 99%

Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study

Kaur,

Mujtahedi,

Fridell

et al. 2023

Clinical Transplantation

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Pancreas transplantation using compatible but non‐identical ABO blood group donors

Abstract: Non-identical but compatible pancreas transplants have similar graft survival compared to ABO identical. Hemolysis may occur so some caution is required.

Cited by 1 publication

References 24 publications

Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study

Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study

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