Pancreas Transplantation

Usova, Eugenia; Каабак, М. М.; Чжао, А. В.

doi:10.1016/s0039-6109(16)43940-x

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…When cold ischemia was limited to 6 hr or less, this complication was no longer seen. This finding is in agreement with the data from the International Pancreas Registry, in which an analysis showed a statistically higher early function and survival rate for grafts preserved less than 6 hr compared to those stored more than 6 hr [12].…”

Section: Discussionsupporting

confidence: 92%

“…It can be hoped, therefore, that the good results in the second subgroup will remain even though the follow-up period is still quite short. It is also encouraging that patients with sustained pancreatic graft function in the present series as well as in others [3,4,12] have such good control of their blood glucose homeostasis, as reflected in a variety of tests. In the present series some patients had an impairment in the intravenous glucose tolerance tests.…”

Section: Discussionsupporting

confidence: 76%

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Progress in segmental pancreatic transplantation

Tydén

Lundgren

et al. 1986

World j. surg.

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Twenty‐nine patients with type I diabetes mellitus and end‐stage diabetic nephropathy were subjected to combined renal and pancreatic transplantation. The 2‐year actuarial patient survival rate was 87% and the renal graft survival rate was 78% for the whole series. The 1‐year and 2‐year actuarial pancreatic graft survival rates were 54% and 40%, respectively. A substantial improvement in the pancreatic graft survival has occurred with time. Thus, in the first part of the series (1981–1983, n = 13), the 1‐year pancreatic graft survival was 31%, whereas in the second part of the series (1984–1985, n = 16), the figure was 75%. The improvement in results was probably due to a reduction in the cold ischemia time and the adoption of an aggressive anticoagulant treatment; using these measures the incidences of pancreatitis and graft thrombosis were much reduced. In all patients with functioning pancreatic grafts, insulin therapy was discontinued and an essentially normal glucose homeostasis was achieved. Among the patients whose pancreatic transplant has survived for a longer period, no further deterioration in retinopathy or neuropathy was found. Furthermore, biopsies from the simultaneously transplanted kidneys in 2 patients 3 years after transplantation have failed to show any increase in the thickness of the glomerular basement membrane indicative of a recurrence of diabetic nephropathy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

Progress in segmental pancreatic transplantation

Tydén

Lundgren

et al. 1986

World j. surg.

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“…Direct abdominal trauma involving the pancreas and a history of diabetes and pancreatitis in a potential donor are contraindications for organ procurement and transplantation (3). However, serum amylase and plasma glucose levels are often abnormal in polytraumatized (4) and cranially traumatized (5,6) individuals.…”

mentioning

confidence: 99%

Influence of Serum Amylase and Plasma Glucose Levels in Pancreas Cadaver Donors on Graft Function in Recipients

Hesse

Sutherland²

1989

Diabetes

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In a series of 101 pancreas transplants from brain cadaver donors, serum amylase levels were determined preoperatively in 47 donors, and plasma glucose levels were monitored in 94 donors. Eighty-six percent of the donors died from head injury and 14% from asphyxia. No donors had a history of diabetes or pancreatitis, and the pancreas was grossly normal in all donors. Of the 47 cadaver pancreas donors in whom serum amylase levels were measured, the values of 20 donors were elevated (110-994 IU/L), and the values of 11 donors were greater than 300 IU/L. In 51 of 94 braindead cadaver pancreas donors in whom plasma glucose determinations were made, hyperglycemia was present (200-980 mg/dl). Early posttransplant pancreas-graft function was excellent in all recipients except for 5 patients in whom the grafts had to be removed for reasons not related to donor serum amylase and plasma glucose levels. Hyperamylasemia and hyperglycemia are probably not contraindications for cadaver pancreas organ donation unless overt pancreatic trauma, pancreatitis, or a history of diabetes is present.

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