Pancreas transplantation: assessing secondary complications and life quality

Zehr, Pamela; Milde, Frances K; Hart, Laura K.; Corry, Robert J.

doi:10.1007/bf00587641

Cited by 24 publications

(8 citation statements)

References 3 publications

(2 reference statements)

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“…11-13 Several studies have reported stabilisation of retinopathy in up to 75% of successful SPK transplant recipients 910 13 14 In contrast, a number of prospective studies have reported that metabolic normalisation of glycaemia in successful SPK transplants has no effect on the subsequent course of diabetic retinopathy 815-19These studies have monitored the course of DR in successful SPK transplants recipients and compared them with less than ideal control groups which consisted of either failed SPK transplant recipients or kidney alone transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

Pearce

Ilango²,

Sells³

et al. 2000

British Journal of Ophthalmology

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Background/aims-Simultaneous pancreas and kidney transplantation (SPK) has become an important option in selected IDDM patients with end stage renal disease (ESRD). Successful SPK transplants are associated with long term normoglycaemic control and improved quality of life. However, debate still continues on the benefit to patients in terms of stabilisation or amelioration of diabetic retinopathy. The progression of diabetic retinopathy (DR) in a cohort of 20 SPK transplant patients is reported. Methods-All patients were reviewed postoperatively with corrected visual acuity, slit lamp examination, and fundal biomicroscopy. Preoperative data were collected retrospectively and DR was considered unstable if there had been a drop in Snellen acuity greater than three lines or a need for laser photocoagulation or vitrectomy in the 2 years preoperatively. Results-20 patients who received SPK transplants between March 1983 and April 1994 were reviewed (mean age 35.1 years; mean duration of IDDM = 24.6 years). 17 patients still had functioning grafts at a mean follow up of 5.1 years. Nine of these patients had unstable DR before transplantation. Of these, 89% (8/9) had stabilised DR following transplantation with only a single case requiring laser photocoagulation. Of the eight patients that had stable DR before transplantation all had stable DR following transplantation. 41% of cases (7/17) required cataract surgery during the follow up period. Conclusions-Advanced diabetic retinopathy is present in a high proportion of cases managed with SPK transplant as a consequence of the duration of IDDM and the presence of ESRD. More than 90% of cases have stable DR following transplant. (Br J Ophthalmol 2000;84:736-740)

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Section: Discussionmentioning

confidence: 99%

Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

Pearce

Ilango²,

Sells³

et al. 2000

British Journal of Ophthalmology

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“…Similarly, solitary pancreas transplantation is performed to make diabetic patients insulin injection-independent, and diabetes is not immediately life threatening. Successful pancreas transplant patients perceive their health as good and have a greater ability to function socially, with life quality becoming better over time (23,24).…”

Section: Discussionmentioning

confidence: 99%

Hand Transplantation: The Milan Experience

Lanzettà¹,

Nolli²,

Vitale³

et al. 2007

Polish Journal of Surgery

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The authors describe the most critical aspects of transplantation of the hand. Three successful cases are presented from the Italian Hand Transplantation National Program. The key issues of this new type of surgical reconstruction for major amputations are selection criteria of suitable candidates, technical aspects of surgery, postoperative regime and functional rehabilitation. Other important aspects are staff requisites and organisation of the clinical trial, ethical and legal implications, dealing with the media. The authors comment on the fact that we might be ready to accept that almost anything could come from a cadaver, even if it is not a life-saving organ, to reconstruct missing parts and restore anatomical integrity and, especially, function.

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“…Additionally, the quality of life and the complications, deriving from diabetic status, have more benefits from pancreas transplantation than from insulin therapeutic plan or from islets encapsulation [29,30].…”

Section: Pancreas Transplantationmentioning

confidence: 99%

Bioengineering the Pancreas: Cell-on-Scaffold Technology

Peloso¹,

Citro²,

Oldani³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Nowadays, type I diabetes mellitus is a pathology afflicting millions of people globally with a dramatic assessment in the next future. Current treatments including exogenous insulin, pancreas transplantation and islets transplantation, are not free from important lifelong side effects. In the last decade, tissue engineering and regenerative medicine have shown encouraging results about the possibility to produce a functional bioengineered pancreas. Among many technologies, decellularization offers the opportunity to produce an organ-specific acellular matrix that could subsequently repopulate with endocrine cellular population. Herein, we aim to review the state-of-art and this technology highlighting the diabetes burden for the healthcare system and the major achievements toward the manufacturing of a bioengineered pancreas obtained by cell-on-scaffold technology.

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Pancreas transplantation: assessing secondary complications and life quality

Cited by 24 publications

References 3 publications

Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

Hand Transplantation: The Milan Experience

Bioengineering the Pancreas: Cell-on-Scaffold Technology

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