Pancreas transplantation

Effect of alginate composition and purity on alginate microspheres

“…The Diabetes Control and Complication Trial (DCCT) showed that use of intensive insulin therapy delayed the onset as well as the progression of existing complications of diabetes (DCCT 1993). In contrast, islet cell transplantation, using the whole pancreas has been clearly shown not only to prevent the development of diabetic complications, but also in some cases, to reverse certain complications of diabetes (Orloff et al 1986, Pyke 1991, Fioretto et al 1998, Caldara et al 1999, probably due to the role played by C-peptide on vascular and neural functions (Ido et al 1997, Hansen et al 2002, Ekberg et al 2003. However, the use of islet cell transplantation as a treatment option for patients with Type 1 diabetes has been severely limited by the shortage of human pancreas and the need to use immunosuppressive drugs to prevent transplant rejection (Shapiro et al 2000).…”

Pancreactic and islet transplantation for diabetes

“…In most, the purpose of the procedure is not made clear (Pyke, 1991;Lefebvre, 1992). The operation has a morbidity, even a mortality.…”

“…Thereafter loss of function continues though at a lower rate. On present projections more than half of the transplanted glands will have failed by 5 years (Sutherland, 1992;Pyke, 1991).…”

“…Those in whom the operation has been successful are very pleased. The prevention of diabetic complications by transplantation has not been shown to be a success nor can it now be expected to be effective (Pyke, 1991;Lefebvre, 1992;Robertson, 1992). If pancreas transplantation is confined, as it should be because of the need for immunosuppression, to patients having a kidney transplant, severe microvascular complications will already be present and the best that can be hoped for is arrest or delay in their progression.…”

“…If pancreas transplantation is confined, as it should be because of the need for immunosuppression, to patients having a kidney transplant, severe microvascular complications will already be present and the best that can be hoped for is arrest or delay in their progression. The evidence that this happens is slender (Pyke, 1991;Lefebvre, 1992;Robertson, 1992). Controlled trials of the value of pancreas transplantation should have been started over 10 years ago.…”