Pancreas Preservation With the University of Wisconsin Versus Celsior Solutions

Manrique, Alejandro; Jiménez, Carlos; Herrero, M.L.; Meneu, J.C.; Abradelo, M.; Moreno, A.; González, Esther; Hernández, Eduardo; Morales, José; Andrés, Amado; Cortina, José M.; Moreno, Enrique

doi:10.1016/j.transproceed.2006.08.058

Cited by 30 publications

(21 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two retrospective studies contrast these reports. In line with this study Manrique et al [47] shows similar 2-year graft and patient survival for University of Wisconsin and Celsior perfused/preserved pancreases. There is, however, consensus regarding equal results using University of Wisconsin or HTK if CIT is less than 12 h. Even though high-volume flush of HTK is recommended by the manufacturer, results of these studies suggest a higher incidence of graft pancreatitis, if the HTK volume exceeds 5 l. Less common is the use of Celsior.…”

Section: Retrieval Techniquesupporting

confidence: 89%

Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation

Maglione¹,

Ploeg

Friend

2013

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

show abstract

Section: Retrieval Techniquesupporting

confidence: 89%

Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation

Maglione¹,

Ploeg

Friend

2013

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

show abstract

“…The authors demonstrated that Celsior and UWS had similar safety profiles for pancreas preservation. Another study reported by Manrique et al [35•] comparing Celsior ( n = 28) with UWS ( n = 44) for pancreas preservation demonstrated that 2-year recipient survival rates, 2-year graft survival rates, pancreas leakage rates, and clinical graft pancreatitis rates were similar in both groups.…”

Section: Pancreas Preservation For Pancreas Transplantationmentioning

confidence: 92%

“…The two main methods used for experimental and clinical organ preservation are static cold storage, which we will simply refer to as cold storage, and machine perfusion [10–20,21•,22•,23–34,35•,36,37•,38–44]. The hypothermic pulsatile machine perfusion technique originally developed by Carrel and Lindbergh in 1935 [45–47] has been widely used for clinical kidney transplants [48] but not for clinical pancreas preservation.…”

Section: Pancreas Preservation For Pancreas Transplantationmentioning

confidence: 99%

Pancreas preservation for pancreas and islet transplantation

Iwanaga

Sutherland

Harmon

et al. 2008

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

Purpose of review To summarize advances and limitations in pancreas procurement and preservation for pancreas and islet transplantation, and review advances in islet protection and preservation. Recent findings Pancreases procured after cardiac death, with in-situ regional organ cooling, have been successfully used for islet transplantation. Colloid-free Celsior and histidine-tryptophan-ketoglutarate preservation solutions are comparable to University of Wisconsin solution when used for cold storage before pancreas transplantation. Colloid-free preservation solutions are inferior to University of Wisconsin solution for pancreas preservation prior to islet isolation and transplantation. Clinical reports on pancreas and islet transplants suggest that the two-layer method may not offer significant benefits over cold storage with the University of Wisconsin solution: improved oxygenation may depend on the graft size; benefits in experimental models may not translate to human organs. Improvements in islet yield and quality occurred from pancreases treated with inhibitors of stress-induced apoptosis during procurement, storage, isolation or culture. Pancreas perfusion may be desirable before islet isolation and transplantation and may improve islet yields and quality. Methods for real-time, noninvasive assessment of pancreas quality during preservation have been implemented and objective islet potency assays have been developed and validated. These innovations should contribute to objective evaluation and establishment of improved pancreas preservation and islet isolation strategies. Summary Cold storage may be adequate for preservation before pancreas transplants, but insufficient when pancreases are processed for islets or when expanded donors are used. Supplementation of cold storage solutions with cytoprotective agents and perfusion may improve pancreas and islet transplant outcomes.

show abstract

“…Furthermore, none of these guidelines preclude dual perfusion when the pancreas is being retrieved, although German standards stipulate portal venous perfusion via a catheter inserted directly into the portal vein above the pancreas/duodenum [45,60,74,75]. The use of Celsior or IGL-1 solution has not yet been incorporated into major National or Regional guidelines, although both have been employed in the clinical context [64,65,72,76].…”

Section: Perfusion Fluid Typesmentioning

confidence: 99%

Pancreas Retrieval for Whole Organ and Islet Cell Transplantation

Hawthorne¹,

Hameed²,

Pleass³

2018

Organ Donation and Transplantation - Current Status and Future Challenges

View full text Add to dashboard Cite

For more than five decades, we have been refining advances in pancreas whole organ and islet cell transplantation as clinical therapies to treat the ever-increasing number of patients suffering from type-1-diabetes. Research and clinical practice have contributed to making both whole organ and cellular transplantation viable therapeutic options for a broader range of patients. Furthermore, both forms of clinical transplantation results have progressively improved, due to the ongoing refinement of organ donation and its various technical processes, combined with the evolution of immunosuppression and patient care now offering excellent long-term treatment for both type-1-diabetes and concomitant renal failure. This chapter provides an overview on how this has been undertaken and achieved over decades to ultimately provide outstanding outcomes on par with other organ transplantation results. Briefly, we cover the history of pancreas retrieval procedures, the importance of donor selection, the intricate processes of the organ donor operation, preservation of the pancreas, and the ideal ways to best improve outcomes for transplantation. Improving and providing the optimal donor and preservation conditions underpinning the success of subsequent whole pancreas or islet transplantation as a safe, effective, and feasible therapeutic option for an increasing number of patients suffering from type-1-diabetes.

show abstract

Pancreas Preservation With the University of Wisconsin Versus Celsior Solutions

Cited by 30 publications

References 8 publications

Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation

Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation

Pancreas preservation for pancreas and islet transplantation

Pancreas Retrieval for Whole Organ and Islet Cell Transplantation

Contact Info

Product

Resources

About