Pancreas-Kidney Transplantation: Do We Know the Frequency of Clinical Complications?

Arroyo, Sebastián Tamayo; Sanz, Luis Marcano; Fernández, Guadalupe Tabernero; Gómez, Patricia; Arroyo, Paulina Herdoiza; Coderque, Mónica; López-Sánchez, Jaime; Sampedro, José Quiñones; Fernández, Luis González; Muñoz-Bellvis, Luís

doi:10.1016/j.transproceed.2021.09.002

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4][5][6][7] Over the last decades, SPKT outcomes have improved, thanks to technical advances, better donor and recipient selection, new immunosuppressive agents, and increased knowledge regarding the management of complications. [8][9][10][11] Despite the promising results, it should be noted that SPKT is a complex procedure that can lead to surgical complications resulting in graft loss, impaired kidney function, increased recipient mortality, and an extended hospital length of stay (LOS). 12,13 Contemporaneous series report relaparotomy rates as high as 35%, and most early pancreas graft losses still occur secondary to technical failures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical complications and technical failure of simultaneous pancreas‐kidney transplantation: A 22‐year experience from a single center

Dias,

Marques,

Cardoso

et al. 2024

Clinical Transplantation

View full text Add to dashboard Cite

Simultaneous pancreas‐kidney transplantation (SPKT) is the best treatment for selected individuals with type 1 diabetes mellitus and end‐stage renal disease. Despite advances in surgical techniques, donor and recipient selection, and immunosuppressive therapies, SPKT remains a complex procedure with associated surgical complications and adverse consequences. We conducted a retrospective study that included 263 SPKT procedures performed between May 2000, and December 2022. A total of 65 patients (25%) required at least one relaparotomy, resulting in an all‐cause relaparotomy rate of 2.04 events per 100 in‐hospital days. Lower donor body mass index was identified as an independent factor associated with reoperation (OR .815; 95% CI: .725–.917, p = .001). Technical failure (TF) occurred in 9.9% of cases, primarily attributed to pancreas graft thrombosis, intra‐abdominal infections, bleeding, and anastomotic leaks. Independent predictors of TF at 90 days included donor age above 36 years (HR 2.513; 95% CI 1.162–5.434), previous peritoneal dialysis (HR 2.503; 95% CI 1.149–5.451), and specific pancreas graft reinterventions. The findings highlight the importance of carefully considering donor and recipient factors in SPKT. The incidence of TF in our study population aligns with the recent series. Continuous efforts should focus on identifying and mitigating potential risk factors to enhance SPKT outcomes, thereby reducing post‐transplant complications.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Over the last decades, SPKT outcomes have improved, thanks to technical advances, better donor and recipient selection, new immunosuppressive agents, and increased knowledge regarding the management of complications 8–11 …”

Section: Introductionmentioning

confidence: 99%