Pancreas head carcinoma with total fat replacement of the dorsal exocrine pancreas

Toyama, Nobuyuki; Kamiyama, Hidenori; Suminaga, Yoshihisa; Namai, Kazuyuki; Ota, Masahiro; Konishi, Fumio

doi:10.1007/s00535-003-1250-4

Cited by 16 publications

(7 citation statements)

References 10 publications

(12 reference statements)

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“…Treatment of pancreatic neoplasia in the setting of DAP does not deviate from current management guidelines [ 13 ]. Surgical resection of pancreatic tumors in patients with DAP often requires resection of the remaining pancreatic tissue, with a high rate of insulin dependent diabetes mellitus and exocrine insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Neuroendocrine Tumor in the Setting of Dorsal Agenesis of the Pancreas

Nassif

Ponchiardi

Sachs

2016

Case Reports in Gastrointestinal Medicine

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Dorsal agenesis of the pancreas (DAP) is an uncommon embryological abnormality where there is absence of the distal pancreas. DAP is mostly asymptomatic, but common presenting symptoms include diabetes mellitus, abdominal pain, pancreatitis, enlarged pancreatic head, and, in a few cases, polysplenia. MRCP and ERCP are the gold standard imaging techniques to demonstrate the absence of the dorsal pancreatic duct. The literature on the association of pancreatic neoplasia and DAP is limited. We present the case of a pancreatic neuroendocrine tumor in a patient with dorsal agenesis of the pancreas, with a review of the related literature.

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Section: Discussionmentioning

confidence: 99%

Pancreatic Neuroendocrine Tumor in the Setting of Dorsal Agenesis of the Pancreas

Nassif

Ponchiardi

Sachs

2016

Case Reports in Gastrointestinal Medicine

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“…18 Proposed criteria for confirming true congenital DAP as opposed to fatty replacement include the complete absence of exocrine features, acinar cells, and islets of Langerhans on histologic examination. 19 Suggested radiologic criteria to diagnose dorsal agenesis of the pancreas have included the lack of a dorsal and transverse pancreatic artery on angiography (rarely performed) and the absence of an accessory pancreatic duct on ERP. 19 However, the most common means of diagnosis is by cross-sectional imaging (CT or MRI/MRCP).…”

Section: Discussionmentioning

confidence: 99%

“…19 Suggested radiologic criteria to diagnose dorsal agenesis of the pancreas have included the lack of a dorsal and transverse pancreatic artery on angiography (rarely performed) and the absence of an accessory pancreatic duct on ERP. 19 However, the most common means of diagnosis is by cross-sectional imaging (CT or MRI/MRCP).…”

Section: Discussionmentioning

confidence: 99%

The Novel Triad of Dorsal Agenesis of the Pancreas with Concurrent Pancreatic Ductal Adenocarcinoma and Nonalcoholic Chronic Calcific Pancreatitis: A Case Series and Review of the Literature

Rittenhouse

Kennedy

Mascaró

et al. 2011

Journal of Gastrointestinal Surgery

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Introduction Dorsal agenesis of the pancreas (DAP) is a rare congenital anomaly, with only 44 cases having been reported in the English literature since 1966. Materials and Methods A retrospective review of our IRB-approved pancreatic surgery database was performed from November 2005 to November 2010 searching for cases of DAP. Discussion Disorders in the retinoic acid (Raldh) and hedgehog (Hh) signaling pathways, which appear to play a role in the development of DAP, have been implicated in other diseases of the pancreas such as pancreatic ductal adenocarcinoma (PDA) and nonalcoholic chronic calcific pancreatitis (NCCP). Conclusion In this report, we describe three cases of DAP in the setting of PDA, two of which include the third component of NCCP. We provide a discussion of the clinical features of this novel triad and address the molecular pathways that relate to these respective diseases.

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“…2, 3, 4 A few pathologic studies of patients with pancreatic cancer have demonstrated fatty infiltraton (FI) in the pancreas parenchyma. 5, 6 FI in the pancreas is positively correlated with age, body mass index (BMI), and a history of DM. 7, 8, 9 …”

Section: Introductionmentioning

confidence: 99%

Association of Pancreatic Fatty Infiltration With Pancreatic Ductal Adenocarcinoma

Hori¹,

Takahashi²,

Hiraoka³

et al. 2014

Clinical and Translational Gastroenterology

136

120

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OBJECTIVES:Fatty infiltration (FI) in the pancreas is positively correlated with high body mass index (BMI) or obesity, and the prevalence of diabetes mellitus (DM), which are well-known risk factors of pancreatic cancer. However, the association of FI in the pancreas with pancreatic cancer is unclear. Recently, we have shown that Syrian golden hamsters feature FI of the pancreas, the severity of which increases along with the progression of carcinogenesis induced by a chemical carcinogen. To translate the results to a clinical setting, we investigated whether FI in the pancreas is associated with pancreatic cancer in a series of patients who had undergone pancreatoduodenectomy.METHODS:In the series, we identified 102 cases with pancreatic ductal adenocarcinoma (PDAC) and 85 controls with cancers except for PDAC. The degree of FI was evaluated histopathologically from the area occupied by adipocytes in pancreas sections, and was compared between the cases and controls.RESULTS:The degree of FI in the pancreas was significantly higher in cases than in controls (median 26 vs. 15%, P<0.001) and positively associated with PDAC, even after adjustment for BMI, prevalence of DM and other confounding factors (odds ratio (OR), 6.1; P<0.001). BMI was identified as the most significantly associated factor with FI in the pancreas.CONCLUSIONS:There is a positive correlation between FI in the pancreas and pancreatic cancer.

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Pancreas head carcinoma with total fat replacement of the dorsal exocrine pancreas

Cited by 16 publications

References 10 publications

Pancreatic Neuroendocrine Tumor in the Setting of Dorsal Agenesis of the Pancreas

Pancreatic Neuroendocrine Tumor in the Setting of Dorsal Agenesis of the Pancreas

The Novel Triad of Dorsal Agenesis of the Pancreas with Concurrent Pancreatic Ductal Adenocarcinoma and Nonalcoholic Chronic Calcific Pancreatitis: A Case Series and Review of the Literature

Association of Pancreatic Fatty Infiltration With Pancreatic Ductal Adenocarcinoma

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