Pancreas and kidney transplantation: long‐term endocrine function

Abstract

The results of this study demonstrate that pancreas transplantation has long-term functional viability, being an essential strategy for the treatment of patients with T1D with end-stage renal failure. Nevertheless, lesser response to OGTT can be expected suggesting certain deterioration in the functional capability of the pancreas graft during follow-up.

Beneficial effect of successful simultaneous pancreas-kidney transplantation on plasma profile of metalloproteinases in type 1 diabetes mellitus patients

“…However, taking into account the advanced vascular wall damage already present at the time of transplantation, being a consequence of several decades of diabetes and subsequent uremia, the expected vascular improvement after SPK is di cult to demonstrate in cohort studies. Additionally, the lack of such evidence can also be explained by non-optimal metabolic e ciency in a signi cant proportion of transplanted pancreas, which may result from their fragmentary thrombosis, and even more from weight gain and increasing insulin resistance after transplantation [21,22]. In line with the above, in the present study the surrogate of arterial stiffness (PWV) and carotid atherosclerosis were shown to be similar in SPK and KTA patients.…”

Short and long-term metabolic outcomes in patients with type 1 and type 2 diabetes receiving a simultaneous pancreas kidney allograft

“…Previous studies focused on the long-term metabolic functions after pancreas transplantation, but they were predominantly confined to T1DM patients receiving a SPK [18,20,42]. Although several studies have described favorable long-term outcomes of pancreas transplantation in Patients with T2DM little information on the metabolic outcome is sparse [9,11,14].…”

Simultaneous pancreas-kidney transplantation: the role in the treatment of type 1 diabetes and endstage renal disease

“…24 Fasting glucose level also remained stable during the same period (3.94 vs. 4.38 mmol/l, p>0.05). 24 However, oral glucose tolerance test (OGTT) demonstrated decreased pancreatic response, indicating certain deterioration in the functional capability of the allograft over the long-term. 24 Whether this is the effect of immunosuppressive medications (i.e.…”

“…23 Mora et al demonstrated that recipients achieved long-term normoglycemic state following SPK transplant. 24 During the 15 year follow-up, HbA1c level remained within normal range with no significant difference between the first and the last year of follow-up (4.68% vs. 4.76%, p>0.05). 24 Fasting glucose level also remained stable during the same period (3.94 vs. 4.38 mmol/l, p>0.05).…”

“…24 During the 15 year follow-up, HbA1c level remained within normal range with no significant difference between the first and the last year of follow-up (4.68% vs. 4.76%, p>0.05). 24 Fasting glucose level also remained stable during the same period (3.94 vs. 4.38 mmol/l, p>0.05). 24 However, oral glucose tolerance test (OGTT) demonstrated decreased pancreatic response, indicating certain deterioration in the functional capability of the allograft over the long-term.…”