Pancratium triflorum Roxb. (Amaryllidaceae) and Molineria trichocarpa (Wight) N.P. Balakr (Hypoxidaceae): Cytotoxic and antioxidant activities

Johnson, M; Maharaja, P.; Janakiraman, N.; Raj, G. Adaikala; Menezes, Irwin Rose Alencar de; Costa, José Galberto Martins da; Verde, Leandro Costa Lima; Coutinho, Henrique Douglas Melo

doi:10.1016/j.fct.2018.02.055

Cited by 9 publications

(2 citation statements)

References 29 publications

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“…[15] A previous study showed that P. triflorum extracts had different IC 50 values for antioxidant activities. [16] The present study substantiates the previous findings. The pink-highlighted area on the bioavailability radar represents the optimal range for each property, providing a glimpse of a molecule's drug-likeliness.…”

Section: Resultssupporting

confidence: 93%

In silico analysis of anti-inflammatory and anticancer properties of bioactive compounds from Pancratium triflorum (Roxb)

KURIAN,

SEBASTIAN

2024

Int. J. Pharm. Sci. Drug Res.

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Herbal remedies with medicinal properties have been utilized in Asian countries for centuries. Recently, Pancratium triflorum Roxb., also known as the forest spider lily, has captured the attention of researchers due to its potential therapeutic benefits. This plant produces white flowers and contains several important phytochemicals, including Lycorine, citrate, Gallic acid, Ellagic acid, Quercetin, and Kaempferol. Molecular docking, a computer simulation technique, has been used to identify potential drug candidates that can bind effectively to the active site of a protein. This study explored the anti-inflammatory and anticancer properties of Pancratium triflorum Roxb.'s Phyto-constituents using molecular docking with Auto dock 4.2.6. The study focused on the Vioxx-bound human Cox2 receptor and the Tyrosine kinase receptor bound to Gliteritinib. Standard ligands were used for redocking, and the Swiss ADME software was employed for bioavailability prediction to validate the findings. The results showed that Lycorine and Crinine have excellent anti-inflammatory properties, while Kaempferol and Quercetin have promising anticancer properties. Further research is necessary, but these findings suggest that Pancratium triflorum Roxb. could be a valuable addition to the medical world. However, further research is required to validate these findings, and in vivo studies are needed to confirm the efficacy and safety of these phytochemicals as potential drug candidates.

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Section: Resultssupporting

confidence: 93%

In silico analysis of anti-inflammatory and anticancer properties of bioactive compounds from Pancratium triflorum (Roxb)

KURIAN,

SEBASTIAN

2024

Int. J. Pharm. Sci. Drug Res.

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“…extract showed, also, the highest value of total flavonoids content with value of 52.71 mg of quercetin equivalents/g of extract. Recently, Johnson et al [ 27 ] reported the total flavonoids content of P. triflorum extracts with values ranging from 386.66 to 4846.66 mg of GAE/g of extract for chloroform and methanol extracts, respectively.…”

Section: Resultsmentioning

confidence: 99%

Investigating the Antiproliferative and Antioxidant Properties of Pancratium maritimum L. (Amaryllidaceae) Stems, Flowers, Bulbs, and Fruits Extracts

Leporini

Catinella

Bruno

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Pancratium maritimum stems, flowers, bulbs, and fruits extracts were investigated for their antiproliferative and antioxidant properties. Total phenols and total flavonoids were also determined. The in vitro antiproliferative activity was tested against seven cancer cell lines such as C32, HeLa, MDA-MB-231, PC3, A549, MCF-7, and LNCaP by using SRB assay. Interesting results were obtained with stems ethanol extract (ET1) against C32 cells (IC50 of 27.1 μg/mL) and fruits aqueous extract (AQ) against MCF-7 cell line (IC50 of 36.5 μg/mL). To define the antioxidant activity, four tests such as DPPH, ABTS FRAP, and β-carotene bleaching tests were used. The most promising ABTS scavenging capacity was observed with fruits ethanol extract (ET1) that showed an IC50 value of 6.9 μg/mL. According to the correlation results, the phenols and flavonoids content could provide a fundamental contribution to the antioxidant and antiproliferative activity of P. maritimum extracts.

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Bioactive Compounds and Biological Activities of the Genus Pancratium

Otari,

Ghane

2023

Reference Series in Phytochemistry

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Pancratium triflorum Roxb. (Amaryllidaceae) and Molineria trichocarpa (Wight) N.P. Balakr (Hypoxidaceae): Cytotoxic and antioxidant activities

Cited by 9 publications

References 29 publications

<i>In silico</i> analysis of anti-inflammatory and anticancer properties of bioactive compounds from <i>Pancratium triflorum</i> (Roxb)

<i>In silico</i> analysis of anti-inflammatory and anticancer properties of bioactive compounds from <i>Pancratium triflorum</i> (Roxb)

Investigating the Antiproliferative and Antioxidant Properties of Pancratium maritimum L. (Amaryllidaceae) Stems, Flowers, Bulbs, and Fruits Extracts

Bioactive Compounds and Biological Activities of the Genus Pancratium

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