Pancoast syndrome in a patient with malignant lymphoma

Wang, Jen C.; Finn, Nomie G.; Nimmagadda, Nagabhushaman; Reddy, Devireddy

doi:10.1002/1097-0142(19891215)64:12<2588::aid-cncr2820641230>3.0.co;2-o

Cited by 13 publications

(4 citation statements)

References 14 publications

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“…Therefore, the diagnosis was confirmed to be B‐cell lymphoma. To our knowledge, five cases of non‐Hodgkin's lymphoma presenting as Pancoast's syndrome have been reported in the English literature 6–10 . The histological type of the majority of these cases is B‐cell lymphoma with the exception of one T‐cell type 9 .…”

Section: Discussionmentioning

confidence: 97%

“…To our knowledge, five cases of non-Hodgkin's lymphoma presenting as Pancoast's syndrome have been reported in the English literature. [6][7][8][9][10] The histological type of the majority of these cases is B-cell lymphoma with the exception of one T-cell type. 9 However, immunoglobulin gene rearrangement analysis was not performed in those cases.…”

Section: Discussionmentioning

confidence: 99%

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Pancoast's syndrome in a patient with B‐cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement

Takahashi

Ohwada

Higashihara³

et al. 2004

Respirology

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Pancoast's syndrome due to malignant lymphoma is extremely rare. A case of diffuse large B-cell lymphoma presenting as Pancoast's syndrome is described. A 66-year-old man complained of pain and weakness of the right arm, and CXR revealed a right apical lung tumour. Histological findings were consistent with it being a diffuse large cell type lymphoma and Southern blot analysis revealed clonal rearrangement of the immunoglobulin heavy-chain JH. Thus, the tumour in this patient was diagnosed to be diffuse large B-cell lymphoma. Malignant lymphoma is an extremely rare cause of Pancoast's syndrome and only five cases have been described. This is the first reported case of Pancoast's syndrome caused by B-cell lymphoma, which was accurately diagnosed by analysis of gene rearrangement.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Pancoast's syndrome in a patient with B‐cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement

Takahashi

Ohwada

Higashihara³

et al. 2004

Respirology

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“…W obrazie radiologicznym BALTL dominują zmiany typowe dla raka oskrzela, takie jak pojedynczy cień okrągły, niedodma, naciek śródmiąższowy z zajęciem lub bez węzłów chłonnych wnęki i ewentualnie śródpiersia, rzadziej płyn w jamie opłucnej [5,6]. Dotychczas opisano tylko 8 przypadków BALTL o obrazie klinicznym guza Pancoasta, z tego jeden w języku japońskim i jeden w hiszpańskim [7][8][9][10][11][12]. W pracy przedstawiono przypadek chorej, u której pod wpływem skojarzonej chemioi radioterapii osiągnięto wyleczenie mimo zaawansowanego stadium BALTL.…”

Section: Wstępunclassified

Pierwotny chłoniak oskrzela o klinicznym przebiegu guza Pancoasta

Zaucha

Jassem²

2007

Advances in Respiratory Medicine

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Okolica szczytu płuca jest wyjątkowo rzadką lokalizacją pierwotnych chłoniaków oskrzela. W pracy przedstawiono przypadek zaawansowanego pierwotnego chłoniaka szczytu lewego płuca rozpoznanego podczas badań przesiewowych u 72-letniej bezobjawowej pacjentki. Przezskórna biopsja cienkoigłowa nie przyniosła rozpoznania histopatologicznego. Było to powodem wykonania otwartej biopsji płuca, w której wykazano obecność zmian charakterystycznych dla chłoniaka B-komórkowego o niskiej złośliwości, marginal zone lymphoma (BALTL); CD20+, CD3−. Zastosowano leczenie skojarzone: 9 cykli chemioterapii i napromienianie masy resztkowej, co pozwoliło na uzyskanie długotrwałej całkowitej remisji.

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“…To our knowledge there has only been one other case report of a malignant lymphoma causing the Pancoast syndrome. 2 Pancoast first described the superior sulcus syndrome in 1924. 3 His original description included pain in the C8-T2 nerve distribution, Homer's syndrome, destruction of upper ribs, and atrophy of hand muscles.…”

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confidence: 99%

Pancoast syndrome caused by a high grade B cell lymphoma

Mills

Han

Dick

et al. 1994

Thorax

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The case history is presented of a 20 year old man with Pancoast syndrome caused by a high grade B cell lymphoma. (Thorax 1994;49:92-93) were of unequal size, the right being larger than the left. He reported no other neurological symptoms, nor did he admit to shortness of breath, cough, sputum production, or haemoptysis.There was no past medical or family history of significance, and the only medication he was taking was simple analgesia. He smoked about 20 cigarettes per day and occasionally drank alcohol.On examination he had a small, left sided ill defined scalene node. There was no evidence of anaemia, cyanosis, or clubbing, and he was apyrexial. His pulse rate was 80 beats/min, regular and equal in volume in both arms. There was an apparent harsh aortic ejection systolic murmur which radiated to the carotid areas and the back.Examination of his chest revealed decreased expansion of the left hemithorax and decreased air entry in the left lung. There was mild wasting of his left pectoralis musculature. Abdominal examination revealed nothing remarkable.His left pupil was considerably smaller than his right. There was anhydrosis and a partial ptosis on the left side, signs in keeping with Horner's syndrome. There was marked wasting of the interossei, thenar and hypothenar eminences of his left hand, and there was a decrease in power of all muscle groups in this hand (grade 3/5). Light touch and pain sensation were decreased in the C8 and Ti dermatomal distribution in his left hand and arm. The rest of the neurological examination was normal.Full blood count, peripheral film, and blood urea and electrolytes were all normal on presentation. Chest radiography (fig 1) showed only a subtle abnormality, which was only appreciated on a high quality film. An echocardiogram showed no valvular defects or chamber abnormalities to account for the detected systolic murmur.Magnetic resonance imaging (MRI) of the patient's brachial plexus and upper thorax was performed and showed extensive superior mediastinal (fig 2A) and left hilar lymphadenopathy ( fig 2B). There was no evidence of rib destruction on the chest radiograph or on the MRI scan; a bone scan was not performed. A computed tomographic (CT) scan of the brain and cerebrospinal fluid examination showed no abnormality.The patient underwent a left anterior mediastinotomy, as it was felt that an adequate and diagnostically reliable sample of tissue could not be obtained from the small ill defined scalene node found on clinical examination. At operation it was noted that the left lung was adherent to the mediastinum, which was solid with tumour and hilar gland involvement. Biopsies of the tumour and a sample of bone marrow were taken.Histological examination of the samples showed the mass to be a high grade nonHodgkin's B cell lymphoma of centroblastic, pleomorphic subtype. The bone marrow specimen showed no evidence of infiltration by lymphoma or other tumour.

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Pancoast syndrome in a patient with malignant lymphoma

Cited by 13 publications

References 14 publications

Pancoast's syndrome in a patient with B‐cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement

Pancoast's syndrome in a patient with B‐cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement

Pierwotny chłoniak oskrzela o klinicznym przebiegu guza Pancoasta

Pancoast syndrome caused by a high grade B cell lymphoma

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