Panayiotopoulos syndrome and Gastaut syndrome are distinct entities in terms of neuropsychological findings

Kalem, Şükriye Akça; Elmalı, Ayşe Deniz; Demirbilek, Veysi; Öktem, Öget; Yapıcı, Zühal; Saltık, Sema; Gökçay, Ahmet; Dervent, Ayşın; Baykan, Betül

doi:10.1016/j.yebeh.2019.106447

Cited by 7 publications

(10 citation statements)

References 22 publications

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“…A study of Akca Kalem’s results hasdemonstrated that patients with PS are more prone to cognitive disabilities than children with Gastaut syndrome. In comparison to GS, people affected by SeLEAS have problems with reading and their intelligence quotient scores are remarkably lower than the results of children with GS [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to current research, there is no significant difference in the prevalence of behavioral dysfunctions between both research groups and healthy control subjects [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to the studies, the pathogenesis of focal epilepsy is associated with a brain network’s abnormality rather than a single CNS area’s dysfunction [ 36 , 37 ]. Identification of an epileptogenic network described as a structure located in the CNS that abnormal neuronal activity leads to epilepsy propagation provides an understanding of the specific syndrome’s mechanism SeLEAS in the pediatric population does not require using invasive procedures during the diagnostic process because of its benign character; however, there is strong evidence that children who are affected by PS are at risk of developing neurocognitive dysfunction in the future [ 22 , 23 , 24 , 25 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Specific challenges can occur during the diagnostic process that can result in misdiagnosis and implementation of inappropriate treatment methods [ 20 , 21 ]. Moreover, patients who are affected by self-limited epilepsy with autonomic seizures are at risk of developing specific neurocognitive complications [ 22 , 23 , 24 , 25 ]. By using EEG, it is possible to distinguish PS from other epileptic syndromes and non-epileptic diseases, although implementing functional neuroimaging techniques could improve the accuracy of the diagnostic process and allow the identification of specific complications [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal and Autonomic Symptoms—How to Improve the Diagnostic Process in Panayiotopoulos Syndrome?

Zontek

Paprocka

2022

Children

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One of the most common epileptic disorders in the pediatric population is Panayiotopoulos syndrome. Clinical manifestations of this idiopathic illness include predominantly autonomic symptoms and dysfunction of the cardiorespiratory system. Another feature constitutes prolonged seizures that usually occur at sleep. It is crucial to differentiate the aforementioned disease from other forms of epilepsy, especially occipital and structural epilepsy and non-epileptic disorders. The diagnostic process is based on medical history, clinical examination, neuroimaging and electroencephalography—though results of the latter may be unspecific. Patients with Panayiotopoulos syndrome (PS) do not usually require treatment, as the course of the disease is, in most cases, mild, and the prognosis is good. The purpose of this review is to underline the role of central autonomic network dysfunction in the development of Panayiotopoulos syndrome, as well as the possibility of using functional imaging techniques, especially functional magnetic resonance imaging (fMRI), in the diagnostic process. These methods could be crucial for understanding the pathogenesis of PS. More data arerequired to create algorithms that will be able to predict the exposure to various complications of PS. It also concerns the importance of electroencephalography (EEG) as a tool to distinguish Panayiotopoulos syndrome from other childhood epileptic syndromes and non-epileptic disorders.

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Section: Resultsmentioning

confidence: 99%

“…According to current research, there is no significant difference in the prevalence of behavioral dysfunctions between both research groups and healthy control subjects [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastrointestinal and Autonomic Symptoms—How to Improve the Diagnostic Process in Panayiotopoulos Syndrome?

Zontek

Paprocka

2022

Children

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“…In one study, Panayiotopoulos syndrome patients scored less in all intelligence scales, verbal and visual memory and psychomotor speed and had more difficulties with reading, writing and arithmetic skills than healthy controls. 27…”

Section: Discussionmentioning

confidence: 99%

Pediatric Occipital Spikes at a Single Center Over 26 Years and the Significance of Tangential Dipole

et al. 2021

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Background: Pediatric occipital epileptiform discharges occur in various clinical settings, including self-limited and treatment-resistant epilepsies. The study objective is to determine electro-clinical predictors for prognosis in children with occipital epileptiform discharges. Methods: 205 patients with occipital epileptiform discharges were classified into seizure groups: self-limited occipital (SLO) (n = 57), including Panayiotopoulos and Gastaut syndrome; non-self-limited occipital (non-SLO) (n = 98), including various seizure etiologies; genetic-generalized (n = 18); febrile (n = 5); and no-seizure (n = 27) groups. Electro-clinical features of the SLO and non-SLO were compared, as this is of most clinical relevance. Results: The median age of seizure onset was 3 years (range: 0-19). Occipital epileptiform discharges with frontal/central positivity were present in both groups, but more common in the SLO than non-SLO groups; 21/57 (36.8%) and 19/98 (19.4%), respectively ( P < .022). However, when occipital epileptiform discharges with tangential dipoles ( P < .048) were accompanied by abnormal ictal eye movements ( P < .037), they were predictive of SLO epilepsy. Conclusions: In our cohort, occipital epileptiform discharges with tangential dipole detected by visual analysis and abnormal ictal eye movements were predictive of SLO epilepsy.

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Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis

Poole,

Phillips,

Killer

et al. 2023

Neuropsychol Rev

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Mathematics incorporates a broad range of skills, which includes basic early numeracy skills, such as subitizing and basic counting to more advanced secondary skills including mathematics calculation and reasoning. The aim of this review was to undertake a detailed investigation of the severity and pattern of early numeracy and secondary mathematics skills in people with epilepsy. Searches were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Twenty adult studies and 67 child studies were included in this review. Overall, meta-analyses revealed significant moderate impairments across all mathematics outcomes in both adults (g= -0.676), and children (g= -0.593) with epilepsy. Deficits were also observed for specific mathematics outcomes. For adults, impairments were found for mathematics reasoning (g= -0.736). However, two studies found that mathematics calculation was not significantly impaired, and an insufficient number of studies examined early numeracy skills in adults. In children with epilepsy, significant impairments were observed for each mathematics outcome: early numeracy (g= -0.383), calculation (g= -0.762), and reasoning (g= -0.572). The gravity of impairments also differed according to the site of seizure focus for children and adults, suggesting that mathematics outcomes were differentially vulnerable to the location of seizure focus.

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Panayiotopoulos syndrome and Gastaut syndrome are distinct entities in terms of neuropsychological findings

Cited by 7 publications

References 22 publications

Gastrointestinal and Autonomic Symptoms—How to Improve the Diagnostic Process in Panayiotopoulos Syndrome?

Gastrointestinal and Autonomic Symptoms—How to Improve the Diagnostic Process in Panayiotopoulos Syndrome?

Pediatric Occipital Spikes at a Single Center Over 26 Years and the Significance of Tangential Dipole

Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis

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