Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway

Li, Qingqing; Zhang, Yansong; Yang, Yufang; Huang, Shuping; Zou, Xiaoqin; Wei, Congying; Liang, Taolin; Zhong, Xin

doi:10.1016/j.biopha.2021.111965

Cited by 17 publications

(17 citation statements)

References 27 publications

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“…Recent literature on the cytoprotective effect of saponins shows their growing interest in the scientific community. Saponins protect against cisplatin-induced nephrotoxicity, gastric toxicity, cardiotoxicity, and ototoxicity [154][155][156]. One of the mechanisms of cytoprotection is carried out by inhibiting the mitochondrial apoptotic pathway by increasing HIF-α protein [154].…”

Section: Combination With Saponinsmentioning

confidence: 99%

“…Saponins protect against cisplatin-induced nephrotoxicity, gastric toxicity, cardiotoxicity, and ototoxicity [154][155][156]. One of the mechanisms of cytoprotection is carried out by inhibiting the mitochondrial apoptotic pathway by increasing HIF-α protein [154]. A few examples of saponins with biological importance include ginsenoside RK1, panax notoginsen, panax quinquefolius, and paris saponin-II [156][157][158].…”

Section: Combination With Saponinsmentioning

confidence: 99%

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Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Dasari

Njiki

Mbemi

et al. 2022

IJMS

115

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Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin, have been widely used to treat a multitude of human cancers. However, a considerable proportion of patients often relapse due to drug resistance and/or toxicity to multiple organs including the liver, kidneys, gastrointestinal tract, and the cardiovascular, hematologic, and nervous systems. In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. Hence, we searched the literature using various scientific databases., such as MEDLINE, PubMed, Google Scholar, and relevant sources, to collect and review relevant publications on cisplatin, natural products, combination therapy, uses in cancer treatment, modes of action, and therapeutic strategies. Our search results revealed that new strategic approaches for cancer treatment, including the combination therapy of cisplatin and natural products, have been evaluated with some degree of success. Scientific evidence from both in vitro and in vivo studies demonstrates that many medicinal plants contain bioactive compounds that are promising candidates for the treatment of human diseases, and therefore represent an excellent source for drug discovery. In preclinical studies, it has been demonstrated that natural products not only enhance the therapeutic activity of cisplatin but also attenuate its chemotherapy-induced toxicity. Many experimental studies have also reported that natural products exert their therapeutic action by triggering apoptosis through modulation of mitogen-activated protein kinase (MAPK) and p53 signal transduction pathways and enhancement of cisplatin chemosensitivity. Furthermore, natural products protect against cisplatin-induced organ toxicity by modulating several gene transcription factors and inducing cell death through apoptosis and/or necrosis. In addition, formulations of cisplatin with polymeric, lipid, inorganic, and carbon-based nano-drug delivery systems have been found to delay drug release, prolong half-life, and reduce systemic toxicity while other formulations, such as nanocapsules, nanogels, and hydrogels, have been reported to enhance cell penetration, target cancer cells, and inhibit tumor progression.

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Section: Combination With Saponinsmentioning

confidence: 99%

Section: Combination With Saponinsmentioning

confidence: 99%

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Dasari

Njiki

Mbemi

et al. 2022

IJMS

115

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“…HIF1A plays a vital role in kidney diseases induced by ischemia and nephrotoxicity [ 50 ]. Panax notoginseng saponins can activate HIF1A signaling to inhibit the mitochondrial apoptosis pathway, thereby reducing CP-induced acute renal injury [ 51 ]. In addition, TP53 (–6.6 kcal/mol) presented a good binding affinity with CUR.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation

et al. 2021

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Cisplatin-induced acute kidney injury (CP-AKI) is a severe complication in patients receiving CP chemotherapy. However, effective therapies for CP-AKI are currently lacking. Curcumin (CUR), a natural polyphenol, is extracted from the rhizome of turmeric and has been reported to have nephroprotective activity. However, the role of CUR in CP-AKI remains unclear. This study aimed to explore the mechanism of CUR in CP-AKI by combining a network pharmacology approach with experimental validations. The analysis revealed 176 potential targets of CUR based on the HERB database and 1,286 related targets of CP-AKI from the GeneCards, DrugBank, and OMIM databases. Further, 106 common targets of CUR against CP-AKI were obtained, and these common targets constructed a protein-protein interaction (PPI) network. In addition, the core targets were screened from the PPI network using Cytoscape. Molecular docking revealed that CUR displayed the best binding to AKT1. Gene Ontology (GO) analysis indicated that the primary biological processes of CUR against CP-AKI included cellular response to chemical stress and apoptotic regulation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis suggested that the PI3K-Akt signaling pathway was most significantly enriched in CUR against CP-AKI. Western blotting and flow cytometry showed that CUR inhibited apoptosis induced by CP by activating the Akt signaling pathway in human kidney tubular epithelial cells (HK-2). Altogether, our findings demonstrated that CUR alleviated apoptosis by activating the Akt signaling pathway in CP-AKI in vitro . These data provide a scientific basis for future investigations into the clinical application of CUR against CP-AKI.

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“…9 Mitochondrial apoptosis signaling pathway is one of the most important apoptotic signaling pathways in the process of apoptosis. 10 In the mitochondrial apoptotic pathway, the anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax are the key proteins that transmit apoptotic signals. 11,12 The mitochondrial membrane is damaged and pores are formed, which leads to the release of various pro-apoptotic proteins in the mitochondrial membrane.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress can not only cause the decrease of PDX‐1 protein expression, but also lead to abnormal nuclear plasmic translocation of PDX‐1, which may be the main reason for the decrease of PDX‐1 binding to insulin mRNA 9 . Mitochondrial apoptosis signaling pathway is one of the most important apoptotic signaling pathways in the process of apoptosis 10 . In the mitochondrial apoptotic pathway, the anti‐apoptotic protein Bcl‐2 and pro‐apoptotic protein Bax are the key proteins that transmit apoptotic signals 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H₂O₂ induced INS‐1 cells

Duan

Zhang

et al. 2022

Environmental Toxicology

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Oxidative stress is an important factor that causes pancreatic β‐cell dysfunction leading to the development and aggravation of diabetes. Swietenine (Stn) and swietenolide (Std) were isolated from the fruits of Swietenia macrophylla King and had the potential effects on treatment and prevention of diabetes. The aim of this study is to investigate the effects of Stn and Std on insulin secretion and apoptosis in H2O2 induced insulinoma cell line (INS‐1) cells. In the present study, INS‐1 cells were treated with 300 μM H2O2 for 4 h to establish the oxidative damage model. Cell apoptosis, insulin secretion, reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) levels, and Caspase‐3 enzyme activity were measured via corresponding methods. Finally, pancreatic duodenal home box factor‐1 (PDX‐1), B cell lymphoma‐2 (Bcl‐2), and Bax protein expression were detected by western blot. Experimental results showed that Stn and Std could significantly improve the INS‐1 cell viability, increase the secretion of insulin and reduce the ROS level in H2O2 induced INS‐1 cells. Furthermore, the SOD and GSH levels increased, and the MDA levels decreased compared with the model group after Stn and Std treatment. In addition, after treated with Stn and Std, cell apoptosis was improved, and the activity of Caspase 3 was also significantly inhibited. Meanwhile, Western blot results showed that Stn and Std could up‐regulate the expression of PDX‐1 protein, and affect the cell apoptosis pathway by up‐regulating the expression of Bcl‐2 protein and down‐regulating the expression of Bax protein. In conclusion, Stn and Std can signifcantly improve the insulin secretion function, protect oxidative stress injury, and reduce apoptosis in H2O2 induced INS‐1 cells, which provides a research basis for Stn and Std to be new drug candidates for the treatment and prevention of diabetes.

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Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway

Cited by 17 publications

References 27 publications

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation

Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H₂O₂ induced INS‐1 cells

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Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway

Cited by 17 publications

References 27 publications

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation

Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H2O2 induced INS‐1 cells

Contact Info

Product

Resources

About

Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H₂O₂ induced INS‐1 cells