Panax notoginseng saponins (PNS) inhibits breast cancer metastasis

Wang, Peiwei; Cui, Jingang; Du, Xiaoye; Yang, Qinbo; Jia, Chenglin; Xiong, Minqi; Yu, Xintong; Li, Li; Wang, Wenjian; Chen, Yu; Zhang, Teng

doi:10.1016/j.jep.2014.04.037

Cited by 70 publications

(44 citation statements)

References 28 publications

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“…P. notoginseng saponins are considered as the major active ingredients in notoginseng. The saponins display multiple pharmacological effects, such as hemostatic [6], [7], [8], [9], antioxidant [10], [11], neuroprotective [12], [13], antitumor [14], [15], antidiabetic [16], [17], and other activities, and have been extensively used as therapeutic agents in China. The pronounced efficacies of notoginseng saponins have led to the development of several Chinese patent medicines, such as Xuesaitong Capsules/Soft Capsules [18] and Xuesaitong Injection [19].…”

Section: Introductionmentioning

confidence: 99%

Endophytic fungi harbored in Panax notoginseng : diversity and potential as biological control agents against host plant pathogens of root-rot disease

Zheng

Miao

Chen

et al. 2017

Journal of Ginseng Research

104

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BackgroundEndophytic fungi play an important role in balancing the ecosystem and boosting host growth. In the present study, we investigated the endophytic fungal diversity of healthy Panax notoginseng and evaluated its potential antimicrobial activity against five major phytopathogens causing root-rot of P. notoginseng.MethodsA culture-dependent technique, combining morphological and molecular methods, was used to analyze endophytic fungal diversity. A double-layer agar technique was used to challenge the phytopathogens of P. notoginseng.ResultsA total of 89 fungi were obtained from the roots, stems, leaves, and seeds of P. notoginseng, and 41 isolates representing different morphotypes were selected for taxonomic characterization. The fungal isolates belonged to Ascomycota (96.6%) and Zygomycota (3.4%). All isolates were classified to 23 genera and an unknown taxon belonging to Sordariomycetes. The number of isolates obtained from different tissues ranged from 12 to 42 for leaves and roots, respectively. The selected endophytic fungal isolates were challenged by the root-rot pathogens Alternaria panax, Fusarium oxysporum, Fusarium solani, Phoma herbarum, and Mycocentrospora acerina. Twenty-six of the 41 isolates (63.4%) exhibited activity against at least one of the pathogens tested.ConclusionOur results suggested that P. notoginseng harbors diversified endophytic fungi that would provide a basis for the identification of new bioactive compounds, and for effective biocontrol of notoginseng root rot.

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Section: Introductionmentioning

confidence: 99%

Endophytic fungi harbored in Panax notoginseng : diversity and potential as biological control agents against host plant pathogens of root-rot disease

Zheng

Miao

Chen

et al. 2017

Journal of Ginseng Research

104

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“…F. H. Chen, also called "Sanqi" in Chinese, is a highly valued medicinal herb that is traditionally prescribed for the treatment of cardiovascular diseases alone or in combination [13]. Numerous clinical and experimental studies have revealed that P. notoginseng and its major active constituents, dammarane-type datriterpenoid saponins (termed ginsenosides) [14], exert extensive protective effects on cardiovascular diseases, including atherosclerosis, hypertension and arrhythmia cordis [15][16][17]. However, the potential benefits of ginsenosides against AAA have not been addressed.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways

Zhang

Tian

et al. 2015

Vascular Pharmacology

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“…Previous studies have shown that P. notoginseng can be effectively used to treat cardiovascular disease, cerebrovascular diseases, diabetes, pain, and bleeding (Ng, 2006;Wang et al, 2009;Yang et al, 2014). Cancer prevention and therapy studies have demonstrated that P. notoginseng is beneficial for the prevention and treatment of colon, liver and breast cancers (Chen et al, 2006;Wang et al, 2007Wang et al, , 2014Toh et al, 2011;He et al, 2012;Wang et al, 2012). Chen et al (2006) demonstrated that P. notoginseng could suppress liver metastasis in C57BL/6 mice.…”

Section: Introductionmentioning

confidence: 99%

Effects ofPanax notoginsengon the Metastasis of Human Colorectal Cancer Cells

Hsieh

Kuo

et al. 2016

Am. J. Chin. Med.

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The goal of this study was to investigate the effect of the Panax notoginseng ethanol extract (PNEE) on the regulation of human colorectal cancer (CRC) metastasis. The migratory, invasive, and adhesive abilities and the expression of metastasis-associated regulatory molecules in cultured human CRC cells (HCT-116) treated with the PNEE were analyzed in this study. The migratory and invasive abilities of HCT-116 cells were reduced after PNEE treatment. The incubation of HCT-116 cells with the PNEE for 24 h decreased MMP-9 expression and increased E-cadherin expression compared with the control group. The adhesion reaction assay indicated that treatment with the PNEE led to significantly decreased HCT-116 adhesion to endothelial cells (EA.hy926 cells). The integrin-1 protein levels in HCT-116 cells were significantly decreased following treatment with the PNEE. Similarly, the protein levels of E-selectin and intercellular adhesion molecule-1 (ICAM-1) were significantly decreased by treatment of the EA.hy926 endothelial cells with PNEE. A scanning electron microscope (SEM) examination indicated that HCT-116 cells treated with LPS combined with the PNEE had a less flattened and retracted shape compared with LPS-treated cells, and this change in shape was found to be a phenomenon of extravasation invasion. The transepithelial electrical resistance (TEER) of the EA.hy926 endothelial cell monolayer increased after incubation with the PNEE for 24 h. A cell-cell permeability assay indicated that HCT-116 cells treated with the PNEE displayed significantly reduced levels of phosphorylated VE-cadherin (p-VE-cadherin). These results demonstrate the antimetastatic properties of the PNEE and show that the PNEE affects cells by inhibiting cell migration, invasion, and adhesion and regulating the expression of metastasis-associated signaling molecules.

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Panax notoginseng saponins (PNS) inhibits breast cancer metastasis

Cited by 70 publications

References 28 publications

Endophytic fungi harbored in Panax notoginseng : diversity and potential as biological control agents against host plant pathogens of root-rot disease

Endophytic fungi harbored in Panax notoginseng : diversity and potential as biological control agents against host plant pathogens of root-rot disease

Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways

Effects ofPanax notoginsengon the Metastasis of Human Colorectal Cancer Cells

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