Panax ginseng Meyer cv. Silvatica phenolic acids protect DNA from oxidative damage by activating Nrf2 to protect HFF-1 cells from UVA-induced photoaging

Sun, Guifan; Wang, Jing; Xu, Xiaohao; Zhai, Lu; Li, Zhenzhuo; Liu, Jianzeng; Zhao, Daqing; Jiang, Rui; Sun, Liwei

doi:10.1016/j.jep.2022.115883

Cited by 7 publications

(8 citation statements)

References 42 publications

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“…These results highlight its function in focusing on molecular pathways linked to UVB-induced cellular damage, suggesting syringic acid as a potential treatment for UVB-induced skin damage. Furthermore, a phenolic acid mixture (PAM) was found with syringic acid that provided protection against UVA-induced damage by reducing cell cycle arrest, oxidative damage, ROS accumulation, Keap1 protein, and malondialdehyde (MDA) [132]. The PAM increases the activity of intracellular antioxidant markers (GSH, GPx, SOD, and CAT), impairs cell cycle regulatory proteins (p53, p21, and p16), and increases collagen secretion and cell survival.…”

Section: Potential Phytochemicals In Pumpkin To Fight Against Skin He...mentioning

confidence: 99%

Green Extraction of Phytochemicals from Fresh Vegetable Waste and Their Potential Application as Cosmeceuticals for Skin Health

Valisakkagari,

Chaturvedi,

Rupasinghe

2024

Processes

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The utilization of bioactive compounds from fresh produce waste, which is gaining attention in the agri-food and cosmetics industries, focuses on employing green extraction over conventional extraction methods. This emerging field addresses environmental concerns about food waste and the uses of bioactive phytochemicals for skin health. Modern green extraction methods aim to minimize the energy-intensive process and the use of harmful solvents. These techniques include ultrasound, microwave, and supercritical fluid extraction, pulsed electric field extraction, pressurized liquid extraction, and subcritical water extraction methods, which provide high efficacy in recovering bioactive phytochemicals from vegetable and root crops. The phytochemicals, such as carotenoids, polyphenols, glucosinolates, and betalains of fresh produce waste, exhibit various therapeutic properties for applications in skin health. These dietary antioxidants help to neutralize free radicals generated by UV radiation, thus preventing oxidative stress, DNA damage, and inflammation. The skin care formulations with these phytochemicals can serve as natural alternatives to synthetic antioxidants that may have toxic and carcinogenic effects. Therefore, this review aims to discuss different green extraction technologies, consumer-friendly solvents, and the beneficial skin health properties of selected phytochemicals. The review highlights recent research on major phytochemicals extracted from vegetables and root crops in relation to skin health.

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Section: Potential Phytochemicals In Pumpkin To Fight Against Skin He...mentioning

confidence: 99%

Green Extraction of Phytochemicals from Fresh Vegetable Waste and Their Potential Application as Cosmeceuticals for Skin Health

Valisakkagari,

Chaturvedi,

Rupasinghe

2024

Processes

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“…The ginsenoside and phenolic phytochemical contents were measured as reported previously, with slight modifications [6,12,14,27]. For ginsenoside evaluations, the 50% ethanol extract (20 µL) was injected onto an analytical reversed phase C18 column, and other conditions were as follows: column temperature: 25 • C; operation time: 105 min; flow rate: 1.0 mL/min; detection: 203 nm; mobile phase: elution A (H 2 O)-elution B (CH 3 CN) using the gradient program; and mobile rate: 0-10 min (19% B), 15 min (20% B), 30 min (23% B), 42 min (30% B), 75 min (35% B), 80 min (60% B), 100 min (90% B), and 105 min (100% B).…”

Section: Hplc Operation Conditions For the Quantification Of Ginsenos...mentioning

confidence: 99%

“…), and oleanane (Ro) forms [1][2][3]6,12]. This metabolite has beneficial properties, namely, antioxidant, antiinflammatory, antidiabetic, anticancer, and immunity enhancements in the field of human health [1,4,6,[12][13][14]. Moreover, this constituent contains abundant value derivatives such as ginsenoside Rb1, Rh2, Rc, Rd, Re, Rf, and Rg1 [1,5,15], and minor ginsenosides (Rg2, Rg3, Rh1, F1, F2, and compound K) have revealed higher biological effects than those in the main ginsenosides [4,12].…”

Section: Introductionmentioning

confidence: 99%

Examining the Alterations in Metabolite Constituents and Antioxidant Properties in Mountain-Cultivated Ginseng (Panax ginseng C.A. Meyer) Organs during a Two-Month Maturation Period

Lee,

Cho,

Kim

et al. 2024

Antioxidants

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The current research was the first to prove the existence of fluctuations in the metabolite constituents and antioxidant properties in different organs (leaves, stems, and roots) of the mountain-cultivated ginseng (MCG) plant during a two-month maturation period. Four metabolites, including fatty acids, amino acids, ginsenosides, and phenolic phytochemicals, exhibited considerable differences in organs and maturation times with the following order: leaves > stems > roots. The predominant metabolite contents were found in leaves, with fatty acid (1057.9 mg/100 g) on 31 May, amino acid (1989.2 mg/100 g) on 13 July, ginsenosides (88.7 mg/g) on 31 May, and phenolic phytochemical (638.3 μg/g) on 31 May. Interestingly, ginsenoside content in leaves were highest, with 84.8 → 88.7 → 82.2 → 78.3 mg/g. Specifically, ginsenosides Re, Rd, and F2 showed abundant content ranging from 19.1 to 16.9 mg/g, 8.5 to 14.8 mg/g, and 9.5 to 13.1 mg/g, respectively. Phenolic phytochemicals exhibited remarkable differences in organs compared to maturation periods, with the highest total phenolic content and total flavonoid content recorded at 9.48 GAE and 1.30 RE mg/g in leaves on 31 May. The antioxidant capacities on radical, FRAP, and DNA protection differed significantly, with leaves on 31 May exhibiting the highest values: 88.4% (DPPH), 89.5% (ABTS), 0.84 OD593 nm (FRAP) at 500 μg/mL, and 100% DNA protection at 50 μg/mL. Furthermore, principal cluster analysis revealed metabolite variability as follows: ginsenoside (83.3%) > amino acid (71.8%) > phenolic phytochemical (61.1%) > fatty acid (58.8%). A clustering heatmap highlighted significant changes in metabolite components under the maturation times for each organ. Our findings suggest that MCG leaves on 31 May may be a potential source for developing nutraceuticals, offering highly beneficial components and strong antioxidants.

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“…23 GPS has also been shown to protect DNA from oxidative damage by activating Nrf2. 24 Although the pharmacological and biological effects of ginseng extracts and their active compounds have been extensively studied, their distinct functions and the underlying mechanisms by which they alleviate intestinal radiation damage remain unclear. In this study, we demonstrated the protective effects of GS, GPA, and GPS against radiation injury by blocking apoptosis and pyroptosis in intestinal epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides and Ginseng Phenolic Acids Relieve Ionizing Radiation-Induced Pyroptosis and Apoptosis in Intestinal Epithelial Cells

Shi,

Chen,

et al. 2023

Natural Product Communications

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Exposure to ionizing radiation (IR) during procedures such as abdominal and pelvic radiotherapy results in severe intestinal injury. In the current study, we demonstrated that a lethal dose of IR triggered intestinal epithelial cell apoptosis and pyroptosis via Caspase-3 cleavage. The ginseng active ingredients, ginsenosides (GS) and ginseng phenolic acids (GPA), significantly inhibited IR-induced apoptosis in IEC-6 cells. GS and GPA also reduced Caspase-3 and GSDME cleavage and HMGB1 and LDH release, thus inhibiting pyroptosis after IR. Moreover, GS- or GPA-treated IEC-6 cells showed reduced reactive oxygen species and DNA damage accumulation. These results suggest that IR induces apoptosis and GSDME-dependent pyroptosis through Caspase-3 activation, which can be relieved by GS and GPA, thus supporting the potential use of GS and GPA in the prevention and treatment of IR-induced intestinal injury.

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Panax ginseng Meyer cv. Silvatica phenolic acids protect DNA from oxidative damage by activating Nrf2 to protect HFF-1 cells from UVA-induced photoaging

Cited by 7 publications

References 42 publications

Green Extraction of Phytochemicals from Fresh Vegetable Waste and Their Potential Application as Cosmeceuticals for Skin Health

Green Extraction of Phytochemicals from Fresh Vegetable Waste and Their Potential Application as Cosmeceuticals for Skin Health

Examining the Alterations in Metabolite Constituents and Antioxidant Properties in Mountain-Cultivated Ginseng (Panax ginseng C.A. Meyer) Organs during a Two-Month Maturation Period

Ginsenosides and Ginseng Phenolic Acids Relieve Ionizing Radiation-Induced Pyroptosis and Apoptosis in Intestinal Epithelial Cells

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