Panax ginseng Leaf Extracts Exert Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats

Lee, Seul Gi; Lee, Yoon Jeong; Jang, Myeong-Hwan; Kwon, Tae Ryong; Nam, Ju-Ock

doi:10.3390/nu9090999

Cited by 33 publications

(21 citation statements)

References 25 publications

(25 reference statements)

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“…In Zucker obese rats, Nopal consumption attenuated hepatic steatosis related to obesity and reduced obesity-related metabolic abnormalities. Vinegar or isolated molecules present in Opuntia cladodes, such as kaempferol or isorhamnetin, used in obese mice models, corroborated the anti-obesity and anti-diabetic potentials of these molecules [15][16][17][18][19][20][21]. These studies suggest that remarkable effects could be observed in rat/mouse models of obesity induced by a high-fat diet (HFD), supplemented with Opuntia cladode powders (OCP).…”

Section: Introductionmentioning

confidence: 76%

Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion

Héliès-Toussaint

Fouché

Naud

et al. 2020

BMC Complement Med Ther

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Background: Obesity is a major public health concern worldwide. A sedentary life and a nutritional transition to processed foods and high-calorie diets are contributing factors to obesity. The demand for nutraceutical foods, such as herbal weight-loss products, which offer the potential to counteract obesity, has consequently increased. We hypothesised that Opuntia cladodes consumption could assist weight management in an obesity prevention context. Methods: This study was designed to explore the anti-adipogenic effects of lyophilised Opuntia cladode powders (OCP) in an in vitro cellular model for adipocyte differentiation and an in vivo high-fat-diet (HFD)-induced obesity rat model. Two OCP were tested, one from wild species O. streptacantha and the second from the most known species O. ficus-indica. Results: Pre-adipocytes 3 T3-F442A were treated by OCP during the differentiation process by insulin. OCP treatment impaired the differentiation in adipocytes, as supported by the decreased triglyceride content and a low glucose uptake, which remained comparable to that observed in undifferentiated controls, suggesting that an antiadipogenic effect was exerted by OCP. Sprague-Dawley rats were fed with a normal or HFD, supplemented or not with OCP for 8 weeks. OCP treatment slightly reduced body weight gain, liver and abdominal fat weights, improved some obesity-related metabolic parameters and increased triglyceride excretion in the faeces. Taken together, these results showed that OCP might contribute to reduce adipogenesis and fat storage in a HFD context, notably by promoting the faecal excretion of fats. Conclusions: Opuntia cladodes may be used as a dietary supplement or potential therapeutic agent in diet-based therapies for weight management to prevent obesity.

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Section: Introductionmentioning

confidence: 76%

Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion

Héliès-Toussaint

Fouché

Naud

et al. 2020

BMC Complement Med Ther

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“…The underlying cause of obesity can be attributed to the diet, genetic disorders, sedentary lifestyle, and psychological factors. The imbalance between energy intake and expenditure also causes the buildup of excess adipose tissue [2].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity

2019

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Obesity is a condition associated with the accumulation of excess fat in the body, energy imbalance, lipogenesis, etc., which increases adipose tissue mass through adipogenesis and poses a health risk. Its prevalence has become an economic burden to the health care system and the world at large. One of the alternatives to tackling obesity involves the use of bioactive compounds. We critically examined the effects of Hibiscus sabdariffa extract (HSE) on various parameters associated with the development of obesity such as; the effect of HSE on body weight, the effect of HSE on lipid accumulation, cholesterol metabolism and plasma parameters, the inhibitory effect of HSE on pancreatic lipase, and the effect of HSE on adipocyte differentiation/adipogenesis. This review has gathered reports on the various anti-obesity effects of H. sabdariffa bioactive compounds in cell and animal models, as well as in humans. Available toxicology information on the consumption of H. sabdariffa revealed that its toxicity is dose-dependent and may cause an adverse effect when administered over a long period of time. Reports have shown that H. sabdariffa derived bioactive compounds are potent in the treatment of obesity with an evident reduction in body weight, inhibition of lipid accumulation and suppression of adipogenesis through the PPARγ pathway and other transcriptional factors.

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“…Obesity is characterized by chronic energy imbalance, excessive body weight, white adipose tissue (WAT) and lipogenesis [1,2,41] In addition, obesity is associated with increased oxidative stress and inflammation. Therefore, the functions of antioxidants in the body cannot be overemphasized.…”

Section: Antioxidant Properties Of Selected Seaweed Carotenoidsmentioning

confidence: 99%

Impact of Seaweed-derived Xanthophyll Carotenoid on Obesity Management: Overview of the Last Decade

Ojulari¹,

Lee²,

Nam³

2020

Preprint

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Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, has led to the development of obesity and its comorbidities, which have emerged as some of the major health issues globally. To combat the disease, many studies have reported the anti-obesity effects of natural compounds in foods, with some advantages over chemical treatments. Carotenoids, particularly xanthophyll derived from seaweeds, have attracted the attention of researchers due to their notable biological activities, which are associated mainly with their antioxidant properties. Their involvement in oxidative stress modulation, regulation of major transcription factors and enzymes as well as their antagonistic effects on various obesity parameters have been examined in both in-vitro and in-vivo studies. The present review is a collation of published research over the last decade on the anti-oxidant properties of seaweed xanthophyll carotenoids, with a focus on fucoxanthin and astaxanthin and their mechanisms of action in obesity prevention and treatment.

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Panax ginseng Leaf Extracts Exert Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats

Cited by 33 publications

References 25 publications

Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion

Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion

Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity

Impact of Seaweed-derived Xanthophyll Carotenoid on Obesity Management: Overview of the Last Decade

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