Panax ginseng inhibits intestinal absorption of toxic Aconitum carmichaeli alkaloids in Vitro

You, Qing; Wang, Yuguang; Hu, Donghua; Liang, Qi; Xiao, Cheng-Rong; H, Tan; Tang, Xiao‐Qing; Gao, Yue

doi:10.1007/s11655-015-2282-3

Cited by 10 publications

(2 citation statements)

References 30 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, active components from Sweroside, 75 Paeoniflorin, 77,79 and Ganjiang 12 mainly reverse AC‐induced alterations in the expressions of calcium regulatory proteins (RyR2, SERCA, and NCX, dihydropteridine reducta‐α1 [DHPR‐a1]) to Ca 2+ overload and related cardiotoxic effects. In recent, Ginseng has been identified to enhance the function of the key efflux transporter P‐glycoprotein (P‐gp, also named MDR1), which limits the absorption of its substrates, like AC, to decrease circulatory AC concentration and its subsequent cardiotoxicity 88‐90 . But Glycyrrhiza exerts an opposite effect on the function of P‐gp 90 .…”

Section: Introductionmentioning

confidence: 99%

“…In recent, Ginseng has been identified to enhance the function of the key efflux transporter P‐glycoprotein (P‐gp, also named MDR1), which limits the absorption of its substrates, like AC, to decrease circulatory AC concentration and its subsequent cardiotoxicity 88‐90 . But Glycyrrhiza exerts an opposite effect on the function of P‐gp 90 . Overall, the combination use of AC‐containing herbs with other drugs is an effective manner to weaken the toxicity and strengthen the efficacy of AC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison

Zhou¹,

Liu

Qiu

et al. 2021

Medicinal Research Reviews

Self Cite

View full text Add to dashboard Cite

Aconitine (AC) is well‐known as the main toxic ingredient and active compound of Aconitum species, of which several aconites are essential herbal medicines of Traditional Chinese Medicine (TCM) and widely applied to treat diverse diseases for their excellent anti‐inflammatory, analgesic, and cardiotonic effects. However, the cardiotoxicity and neurotoxicity of AC attracted a lot of attention and made it a favorite botanic poison in history. Nowadays, the narrow therapeutic window of AC limits the clinical application of AC‐containing herbal medicines; overdosing on AC always induces ventricular tachyarrhythmia and heart arrest, both of which are potentially lethal. But the underlying cardiotoxic mechanisms remained chaos. Recently, beyond its cardiotoxic effects, emerging evidence shows that low doses of AC or its metabolites could generate cardioprotective effects and are necessary to aconite's clinical efficacy. Consistent with TCM's theory that even toxic substances are powerful medicines, AC thus could not be simply identified as a toxicant or a drug. To prevent cardiotoxicity while digging the unique value of AC in cardiac pharmacology, there exists a huge urge to better know the characteristic of AC being a cardiotoxic agent or a potential heart drug. Here, this article reviews the advances of AC metabolism and focuses on the latest mechanistic findings of cardiac efficacy and toxicity of this aconite alkaloid or its metabolites. We also discuss how to prevent AC‐related cardiotoxicity, as well as the issues before the development of AC‐based medicines that should be solved, to provide new insight into the paradoxical nature of this ancient poison.

show abstract