Panax ginseng Improves Senile Testicular Function in Rats

Hwang, Seock-Yeon; Sohn, Sang-Hyun; Wee, Jae-Joon; Yang, Jin-Bae; Kyung, Jong-Soo; Kwak, Youn‐Sig; Kim, Sung-Won; Kim, Si-Kwan

doi:10.5142/jgr.2010.34.4.327

Cited by 29 publications

(18 citation statements)

References 27 publications

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“…Lack of serum FSH production was observed when red Korean Panax ginseng given to mice and as a sequence reproductive organ weights as well as spermatogenesis were not affected. These findings were in controversy with those published by others [20]. Androgenic functions are linked to the main anatomical compartments of the testis, the seminiferous tubules, and Leydig cells [42].…”

Section: Discussioncontrasting

confidence: 44%

“…In addition, an increase in testosterone, follicular stimulating hormone (FSH), and luteinizing hormone serum levels was reported after ginseng treatment [19,21]. Furthermore, Panax ginseng is one of the oldest and best-known medicinal plants used to prevent sexual dysfunction with several other pharmacological properties and potential therapeutic applications [20]. Studies suggest that the antioxidant and organ protective actions of the ginseng are associated with enhanced nitric oxide (NO) synthesis in the endothelium of the lung, heart, kidney, and corpus cavernosum [22].…”

Section: Introductionmentioning

confidence: 98%

“…It is considered to be the most valuable medicinal plant of all herbs in the Orient used in treatment of almost every possible disease ranging from anxiety to cancer [17,18]. It has been postulated that red Korean Panax ginseng is traditionally used to enhance libido and fertility in males leading to an increased sperm number and motility [19,20]. In addition, an increase in testosterone, follicular stimulating hormone (FSH), and luteinizing hormone serum levels was reported after ginseng treatment [19,21].…”

Section: Introductionmentioning

confidence: 99%

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Comparative effects of Orchis anatolica vs. the red Korean Panax ginseng treatments on testicular structure and function of adult male mice

Khouri

Daradka

Allouh

et al. 2014

Journal of Complementary and Integrative Medicine

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Section: Discussioncontrasting

confidence: 44%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Comparative effects of Orchis anatolica vs. the red Korean Panax ginseng treatments on testicular structure and function of adult male mice

Khouri

Daradka

Allouh

et al. 2014

Journal of Complementary and Integrative Medicine

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“…Some clinical and experimental studies have reported that P. ginseng has a preventive effect on age-related organ dysfunction and anti-glycation activity (33)(34)(35)(36). In earlier studies, KRG inhibited advanced glycation end product-mediated renal injury (37) and cyclosporineinduced renal injury (38).…”

Section: J Nutr Scimentioning

confidence: 99%

A High-Fat Diet Increases Oxidative Renal Injury and Protein Glycation in D-Galactose-Induced Aging Rats and Its Prevention by Korea Red Ginseng

Park

Kim

Min

et al. 2014

J Nutr Sci Vitaminol

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Summary Declining renal function is commonly observed with age. Obesity induced by a high-fat diet (HFD) may reduce renal function. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and have an anti-aging effect. This study was designed to investigate whether HFD would accelerate the d-galactose-induced aging process in the rat kidney and to examine the preventive effect of KRG on HFD and d-galactose-induced aging-related renal injury. When rats with d-galactose-induced aging were fed an HFD for 9 wk, enhanced oxidative DNA damage, renal cell apoptosis, protein glycation, and extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage, were observed in renal glomerular cells and tubular epithelial cells. However, treatment of rats with HFDplus d-galactose-induced aging with KRG restored all of these renal changes. Our data suggested that a long-term HFD may enhance d-galactose-induced oxidative renal injury in rats and that this age-related renal injury could be suppressed by KRG through the repression of oxidative injury.

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“…; Hwang et al . ) in human and animal models. Moreover, ginseng use is reported to exhibit no adverse effects on pregnancy outcomes (Holst et al .…”

mentioning

confidence: 99%

Foetal exposure to Panax ginseng extract reverts the effects of prenatal dexamethasone in the synthesis of testosterone by Leydig cells of the adult rat

Wanderley

Saraiva

Vieira

et al. 2013

Int J Experimental Path

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The aim of this study was to examine the effect of maternal exposure to Panax ginseng extract (GE) on the prenatal dexamethasone (DEXA)-induced increase in testosterone production by isolated Leydig cells in adult rats. Pregnant rats were treated with (i) GE (200 mg/kg) or vehicle on days 10-21; (ii) DEXA (100 μg/kg) or vehicle on days 14-21; or (iii) a combination of GE plus DEXA at the same doses and with the same regimen. Testosterone production was induced either by the activator of protein kinase A (dbcAMP) or substrates of steroidogenesis [22(R)-hydroxycholesterol (22(R)-OH-C)] and pregnenolone. The capacity of rat Leydig cells exposed to DEXA to synthesize testosterone induced by dbcAMP, 22(R)-OH-C or pregnenolone was increased in comparison with the control group. Combined exposure to DEXA + GE prevented the effect of DEXA on the responsiveness of Leydig cells to all inductors of testosterone synthesis, whereas GE alone did not modify the response to inductors. No modifications in testosterone production were observed under basal conditions. StAR immunoexpression in Leydig cells was not modified by prenatal exposure to DEXA, GE or DEXA + GE. P450scc and glucocorticoid receptor immunoexpression was higher in offspring exposed to DEXA in comparison with the control group. This increased expression was prevented by combined treatment with DEXA + GE. The present findings demonstrate that GE is capable of reversing the effect of DEXA on testosterone synthesis by rat Leydig cells.

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Panax ginseng Improves Senile Testicular Function in Rats

Cited by 29 publications

References 27 publications

Comparative effects of Orchis anatolica vs. the red Korean Panax ginseng treatments on testicular structure and function of adult male mice

Comparative effects of Orchis anatolica vs. the red Korean Panax ginseng treatments on testicular structure and function of adult male mice

A High-Fat Diet Increases Oxidative Renal Injury and Protein Glycation in D-Galactose-Induced Aging Rats and Its Prevention by Korea Red Ginseng

Foetal exposure to Panax ginseng extract reverts the effects of prenatal dexamethasone in the synthesis of testosterone by Leydig cells of the adult rat

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