PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases

Akyildiz, Ian F.; Ghovanloo, Maysam; Güler, Ülkühan; Ozkaya‐Ahmadov, Tevhide; Sarioglu, A. Fatih; Unluturk, Bige D.

doi:10.1109/access.2020.3012139

“…Meanwhile, continuous long-term monitoring of these vital signs may be used for management of chronic diseases as well as data collection to predict future attacks. Recently, researchers also considered applying IoBNT concept for detection and mitigation of infectious diseases [15] where bio-hybrid BNTs constantly monitors for biomarkers released by infectious microorganisms. Other biomarkers that would be interesting to monitor by IoBNT would be glucose.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Although there are many recent survey articles focused on particular aspects of IoBNT [7,13,3,6,14,15,9,16], this comprehensive review is aimed at providing a broader snapshot of the state-of-the-art in the entire IoBNT ield in order to contribute to an holistic understanding of the current technological challenges and potential research directions.…”

Section: Introductionmentioning

confidence: 99%

Internet of Bio-Nano Things: A review of applications, enabling technologies and key challenges

Kuscu¹,

Unluturk²

2021

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Internet of Bio-Nano Things (IoBNT) is envisioned to be a heterogeneous network of nanoscale and biological devices, so called Bio-Nano Things (BNTs), communicating via non-conventional means, e.g., molecular communications (MC), in non-conventional environments, e.g., inside human body. The main objective of this emerging networking framework is to enable direct and seamless interaction with biological systems for accurate sensing and control of their dynamics in real time. This close interaction between bio and cyber domains with unprecedentedly high spatio-temporal resolution is expected to open up vast opportunities to devise novel applications, especially in healthcare area, such as intrabody continuous health monitoring. There are, however, substantial challenges to be overcome if the enormous potential of the IoBNT is to be realized. These range from developing feasible nanocommunication and energy harvesting techniques for BNTs to handling the big data generated by IoBNT. In this survey, we attempt to provide a comprehensive overview of the IoBNT framework along with its main components and applications. An investigation of key technological challenges is presented together with a detailed review of the state-of-the-art approaches and a discussion of future research directions.

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“…Recently, researchers also considered applying IoBNT concept for detection and mitigation of infectious diseases [15] where bio-hybrid BNTs constantly monitors for biomarkers released by infectious microorganisms. Other biomarkers that would be interesting to monitor by IoBNT would be glucose.…”

Section: Iobnt Applicationsmentioning

confidence: 99%

“…Although there are many recent survey articles focused on particular aspects of IoBNT [7], [13], [3], [6], [14], [15], [9], [16], this comprehensive review is aimed at providing a broader snapshot of the state-of-the-art in the entire IoBNT field in order to contribute to an holistic understanding of the current technological challenges and potential research directions.…”

Section: Introductionmentioning

confidence: 99%

Internet of Bio-Nano Things: A Review of Applications, Enabling Technologies and Key Challenges

Kuscu¹,

Unluturk²

2021

Preprint

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Internet of Bio-Nano Things (IoBNT) is envisioned to be a heterogeneous network of nanoscale and biological devices, so called Bio-Nano Things (BNTs), communicating via non-conventional means, e.g., molecular communications (MC), in non-conventional environments, e.g., inside human body. The main objective of this emerging networking framework is to enable direct and seamless interaction with biological systems for accurate sensing and control of their dynamics in real time. This close interaction between bio and cyber domains with unprecedentedly high spatio-temporal resolution is expected to open up vast opportunities to devise novel applications, especially in healthcare area, such as intrabody continuous health monitoring. There are, however, substantial challenges to be overcome if the enormous potential of the IoBNT is to be realized. These range from developing feasible nanocommunication and energy harvesting techniques for BNTs to handling the big data generated by IoBNT. In this survey, we attempt to provide a comprehensive overview of the IoBNT framework along with its main components and applications. An investigation of key technological challenges is presented together with a detailed review of the state-of-the-art approaches and a discussion of future research directions.

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“…Since the capabilities of individual bio-nanomachines may be limited to simple sensing and actuation, the internet of bio-nano things (IoBNT) [3] is envisioned to enable the interconnection of several bio-nanomachines to perform complex tasks. Applications of IoBNT include intra-body sensing and actuation, connectivity control, control of toxic gases and pollution in the environment [3], and diagnosis and mitigation of infectious diseases [4].…”

Section: Introductionmentioning

confidence: 99%

On the Performance of the Primary and Secondary Links in a 3-D Underlay Cognitive Molecular Communication

Sabu¹,

Varshney²,

Gupta³

2021

Preprint

0

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Molecular communication often involves coexisting links where certain links may have priority over others. In this work, we consider a system in three-dimensional (3-D) space with two coexisting communication links, each between a point transmitter and fully-absorbing spherical receiver (FAR), where the one link (termed primary) has priority over the second link (termed secondary). The system implements the underlay cognitive-communication strategy for the co-existence of both links, which use the same type of molecules for information transfer. Mutual influence of FARs existing in the same communication medium results in competition for capturing the information-carrying molecules. In this work, first, we derive an approximate hitting probability equation for a diffusion-limited molecular communication system with two spherical FARs of different sizes considering the effect of molecular degradation. The derived equation is then used for the performance analysis of primary and secondary links in a cognitive molecular communication scenario. We show that the simple transmit control strategy at the secondary transmitter can improve the performance of the overall system. We study the influence of molecular degradation and decision threshold on the system performance. We also show that the systems parameters need to be carefully set to improve the performance of the system.

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PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases

Cited by 52 publications

References 55 publications

Internet of Bio-Nano Things: A review of applications, enabling technologies and key challenges

Internet of Bio-Nano Things: A review of applications, enabling technologies and key challenges

Internet of Bio-Nano Things: A Review of Applications, Enabling Technologies and Key Challenges

On the Performance of the Primary and Secondary Links in a 3-D Underlay Cognitive Molecular Communication

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