Pan‐European agreement on dry cow therapy

Bradley, Andrew J.; Vliegher, Sarne De; Farre, Michael; Jiménez, Luis M.; Peters, Thomas M.; Leemput, Ellen Schmitt-Van De; Werven, T. van

doi:10.1136/vr.k2382

Cited by 18 publications

(21 citation statements)

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“…Herds were selected because they had a working relationship with the University of Minnesota, Cornell University, Iowa State University, DairyExperts Inc., or Dairy Health and Management Services, had a herd size sufficiently large to dry off 15 cows per week, had an average bulk milk SCC less than 250,000 cells/mL during the previous 12 mo, were on a monthly DHIA testing schedule (i.e., individual cow SCC and milk weight measurements), and routinely and consistently recorded clinical mastitis and culling events. The bulk tank SCC threshold was used as an inclusion criterion, as it has been suggested by mastitis experts that herds with lower bulk milk SCC are more likely to benefit from SDCT (Bradley et al, 2018).…”

Section: Study Herdsmentioning

confidence: 99%

“…Another potential source of variability in responses to algorithm-guided SDCT is the algorithm itself. Many algorithms have been recommended by mastitis experts (Bradley et al, 2018;Gohary and McDougall, 2018;Vasquez et al, 2018), which use as few data points as possible (typically using only SCC and clinical mastitis data), to facilitate implementation under farm conditions. In the study by Scherpenzeel et al (2014), the SCC component of Non-inferiority analysis of dry period IMI cure risk for 2 selective dry cow therapy programs (SDCT), as compared with blanket dry cow therapy.…”

Section: Algorithm-guided Sdctmentioning

confidence: 99%

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Randomized controlled non-inferiority trial investigating the effect of 2 selective dry-cow therapy protocols on antibiotic use at dry-off and dry period intramammary infection dynamics

Rowe

Godden

Nydam

et al. 2020

Journal of Dairy Science

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Selective dry-cow therapy (SDCT) could be used to reduce antibiotic use on commercial dairy farms in the United States but is not yet widely adopted, possibly due to concerns about the potential for negative effects on cow health. The objective of this study was to compare culture-and algorithm-guided SDCT programs with blanket dry-cow therapy (BDCT) in a multi-site, randomized, natural exposure, non-inferiority trial for the following quarter-level outcomes: antibiotic use at dry-off, dry period intramammary infection (IMI) cure risk, dry period new IMI risk, and IMI risk at 1 to 13 d in milk (DIM). Two days before planned dry-off, cows in each of 7 herds were randomly allocated to BDCT, culture-guided SDCT (cult-SDCT), or algorithm-guided SDCT (alg-SDCT). At dry-off, BDCT cows received an intramammary antibiotic (500 mg of ceftiofur hydrochloride) in all 4 quarters. Antibiotic treatments were selectively allocated to quarters of cult-SDCT cows by treating only quarters from which aseptically collected milk samples tested positive on the Minnesota Easy 4Cast plate (University of Minnesota, St. Paul, MN) after 30 to 40 h of incubation. For alg-SDCT cows, antibiotic treatments were selectively allocated at the cow level, with all quarters receiving antibiotic treatment if the cow had either a Dairy Herd Improvement Association test somatic cell count >200,000 cells/ mL during the current lactation or 2 or more clinical mastitis cases during the current lactation. All quarters of all cows were treated with an internal teat sealant. Intramammary infection status at enrollment and at 1 to 13 DIM was determined using standard bacteriological methods. The effect of treatment group on dry period IMI cure, dry period new IMI, and IMI risk at 1 to 13 DIM was determined using generalized linear mixed models (logistic), with marginal standardization to derive risk difference (RD) estimates. Quarter-level antibiotic use at dry-off for each group was BDCT (100%), cult-SDCT (45%), and alg-SDCT (45%). The crude dry period IMI cure risk for all quarters was 87.5% (818/935), the crude dry period new IMI risk was 20.1% (764/3,794), and the prevalence of IMI at 1 to 13 DIM was 23% (961/4,173). Non-inferiority analysis indicated that culture-and algorithm-guided SDCT approaches performed at least as well as BDCT for dry period IMI cure risk. In addition, the final models indicated that the risks for each of the 3 IMI measures were similar between all 3 treatment groups (i.e., RD estimates and 95% confidence intervals all close to 0). These findings indicate that under the conditions of this trial, culture-and algorithm-guided SDCT can substantially reduce antibiotic use at dry-off without negatively affecting IMI dynamics.

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Section: Study Herdsmentioning

confidence: 99%

Section: Algorithm-guided Sdctmentioning

confidence: 99%

Randomized controlled non-inferiority trial investigating the effect of 2 selective dry-cow therapy protocols on antibiotic use at dry-off and dry period intramammary infection dynamics

Rowe

Godden

Nydam

et al. 2020

Journal of Dairy Science

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“…As reported in the literature, in-teats infusions of slowrelease antibiotic preparations should cure the existing IMIs and protect the cows by new infections that could originate from this period [11]. As the prevalence of persistent contagious pathogens declined over-time, the need for a blanket dry cow therapy consequently decreased [11,12]. The change has been also promoted by several controversies concerning the complex, and sometimes unclear, cause and effect relationship existing between this type of therapy and the appearance of antibiotic-resistant microorganisms [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…As the prevalence of persistent contagious pathogens declined over-time, the need for a blanket dry cow therapy consequently decreased [11,12]. The change has been also promoted by several controversies concerning the complex, and sometimes unclear, cause and effect relationship existing between this type of therapy and the appearance of antibiotic-resistant microorganisms [11,12]. As a result, the attention has been focused on different strategies such as the selective dry cow therapy: a pathogen-, cow-and herd-specific treatment method [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…The change has been also promoted by several controversies concerning the complex, and sometimes unclear, cause and effect relationship existing between this type of therapy and the appearance of antibiotic-resistant microorganisms [11,12]. As a result, the attention has been focused on different strategies such as the selective dry cow therapy: a pathogen-, cow-and herd-specific treatment method [7,12,13]. Nevertheless, even the latter cannot be considered as a universal remedy because herd characteristics and management can deeply limit its use at an individual-cow level [11].…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic dry buffalo therapy: effect of intramammary administration of benzathine cloxacillin against Staphylococcus aureus mastitis in dairy water buffalo

et al. 2020

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Background: Mastitis is one of the most costly diseases in Mediterranean buffalo (MB). At present, just a few specific antibiotics registered for this dairy specie have been synthetized. Efficacy of an antibiotic dry buffalo therapy (aDBT) against Staphylococcus aureus (S. aureus) mastitis, based on intra-quarter administration of 600 mg of benzathine cloxacillin, have been evaluated for the first time. Eighty MB's quarters received a drying-off therapy (aDBT-group) and 80 were left untreated (no-aDBT-group). They were sampled at drying-off (pre-treatment) and at the resumption of milking [< 10 days in milk (DIM)]. Fresh calver mastitis rate, dry period new mastitis rate, dry period cure rate, and persistent mastitis rate were calculated for clinical monitoring. Overall proportion of positive quarters/ animals, quarters affected by mastitis or intramammary infections (IMI), effects on somatic cell count (SCC) and milk yield were also assessed. Results: An inter-group difference (aDBT vs. no-aDBT) was recorded for all the indexes considered. An intra-group (drying-off vs. < 10 DIM) difference was detected in aDBT-group regarding the proportion of positive-cultured quarters and animals. Concerning the latter, an inter-groups difference was also recorded at second sampling. No clinical mastitis due to the S. aureus was observed. Regarding the subclinical ones, a higher intra-group difference was observed in aDBT than no-aDBT group, while an inter-group difference was recorded at second sampling. No protective effect was observed against IMI. SCC showed an inter-group difference at second sampling, while none difference was instead detected for milk yield. Conclusions: The effects against S. aureus mastitis of benzathine cloxacillin administration at drying-off were assessed for the first time in MB. Its use shows encouraging results in reducing the proportion of mastitis and positive animals at the resumption of the lactation.

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Impact of adopting non‐antibiotic dry‐cow therapy on the performance and udder health of dairy cows

et al. 2022

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Background On dairy farms, the prophylactic use of antibiotics at drying‐off is being increasingly challenged. The objective of this study was to examine the effect of antibiotic dry‐cow therapy (DCT) or non‐antibiotic DCT on dairy cow performance and udder health. Methods Holstein cows (n = 285) with low risk of intramammary infection (<200,000 cells/ml) were assigned to one of two treatments, either antibiotic DCT (A + TS; antibiotic treatment in combination with internal and external teat sealants) or non‐antibiotic DCT (TS; internal and external teat sealant only). Results There was no statistically significant (p > 0.05) difference between treatments for mean cow milk yield, composition or energy corrected milk yield. Mean somatic cell count was 0.16 loge higher in the TS treatment (95% confidence interval [CI]: −0.00 loge to −0.33 loge) compared to A + TS treatment (p = 0.047). A 50% increase in the number of mastitis cases was observed in the A + TS treatment compared to TS treatment (odds ratio = 1.5, 95% CI: 0.80%–3.01%), although this was not significant. There was no statistical evidence (p > 0.05) that treatment had any effect on colostrum quality and composition. Conclusion Results indicate that non‐antibiotic DCT can be adopted in ‘low‐risk’ cows who were offered grass silage‐based diets in cubicle accommodation, with low risk of adverse effects on performance or udder health.

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Pan‐European agreement on dry cow therapy

Cited by 18 publications

References 0 publications

Randomized controlled non-inferiority trial investigating the effect of 2 selective dry-cow therapy protocols on antibiotic use at dry-off and dry period intramammary infection dynamics

Randomized controlled non-inferiority trial investigating the effect of 2 selective dry-cow therapy protocols on antibiotic use at dry-off and dry period intramammary infection dynamics

Antibiotic dry buffalo therapy: effect of intramammary administration of benzathine cloxacillin against Staphylococcus aureus mastitis in dairy water buffalo

Impact of adopting non‐antibiotic dry‐cow therapy on the performance and udder health of dairy cows

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