“…We also identified the most significant GEARs in individual cancer types, such as TLL1 (BLCA), PGK1 (BRCA), RFXANK (CESC), DPP7 (COAD), VWA8 (KIRC), SCMH1 (LGG), HILPDA (LIHC), TLE1 (LUAD), CD151 (LUSC), ANKRD13A (OV), SOCS2 (PAAD), DRG2 (PRAD), ADAMTS6 (STAD), PSMB8 (THCA), ASS1 (UCEC) (Table 3). Many of these genes were previously reported to associate with tumorigenesis 18,[29][30][31][32][33][34][35][36][37][38][39][40] . For example, TLE1 is known as a transcriptional repressor that promotes cell proliferation, migration, and inhibits apoptosis in LUAD 41,42 .…”